T cell receptor (TCR) signaling in health and disease
Shah, Kinjal LU ; Al-Haidari, Amr LU ; Sun, Jianmin LU and Kazi, Julhash U. LU
(2021)
In Signal Transduction and Targeted Therapy
6(1).
- Abstract
- Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes with the help of specific transcription factors. These signaling networks propagate with the help of various effector enzymes, such as kinases, phosphatases, and phospholipases. Integration of these disparate signal transduction pathways is done with the help of adaptor proteins that are non-enzymatic in function and that serve as a scaffold for various protein–protein interactions. This process aids in connecting the proximal to distal signaling... (More)
- Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes with the help of specific transcription factors. These signaling networks propagate with the help of various effector enzymes, such as kinases, phosphatases, and phospholipases. Integration of these disparate signal transduction pathways is done with the help of adaptor proteins that are non-enzymatic in function and that serve as a scaffold for various protein–protein interactions. This process aids in connecting the proximal to distal signaling pathways, thereby contributing to the full activation of T cells. This review provides a comprehensive snapshot of the various molecules involved in regulating T cell receptor signaling, covering both enzymes and adaptors, and will discuss their role in human disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/fcce3fdb-b324-4582-a554-f641fe4e57f9
- author
- Shah, Kinjal
LU
; Al-Haidari, Amr
LU
; Sun, Jianmin
LU
and Kazi, Julhash U.
LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Signal Transduction and Targeted Therapy
- volume
- 6
- issue
- 1
- article number
- 412
- publisher
- Springer Nature
- external identifiers
-
- pmid:34897277
- scopus:85121048530
- ISSN
- 2059-3635
- DOI
- 10.1038/s41392-021-00823-w
- language
- English
- LU publication?
- yes
- id
- fcce3fdb-b324-4582-a554-f641fe4e57f9
- date added to LUP
- 2021-12-17 15:15:37
- date last changed
- 2022-08-05 08:39:03
@article{fcce3fdb-b324-4582-a554-f641fe4e57f9,
abstract = {{Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes with the help of specific transcription factors. These signaling networks propagate with the help of various effector enzymes, such as kinases, phosphatases, and phospholipases. Integration of these disparate signal transduction pathways is done with the help of adaptor proteins that are non-enzymatic in function and that serve as a scaffold for various protein–protein interactions. This process aids in connecting the proximal to distal signaling pathways, thereby contributing to the full activation of T cells. This review provides a comprehensive snapshot of the various molecules involved in regulating T cell receptor signaling, covering both enzymes and adaptors, and will discuss their role in human disease.}},
author = {{Shah, Kinjal and Al-Haidari, Amr and Sun, Jianmin and Kazi, Julhash U.}},
issn = {{2059-3635}},
language = {{eng}},
number = {{1}},
publisher = {{Springer Nature}},
series = {{Signal Transduction and Targeted Therapy}},
title = {{T cell receptor (TCR) signaling in health and disease}},
url = {{http://dx.doi.org/10.1038/s41392-021-00823-w}},
doi = {{10.1038/s41392-021-00823-w}},
volume = {{6}},
year = {{2021}},
}