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T cell receptor (TCR) signaling in health and disease

Shah, Kinjal LU ; Al-Haidari, Amr LU ; Sun, Jianmin LU and Kazi, Julhash U. LU orcid (2021) In Signal Transduction and Targeted Therapy 6(1).
Abstract
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes with the help of specific transcription factors. These signaling networks propagate with the help of various effector enzymes, such as kinases, phosphatases, and phospholipases. Integration of these disparate signal transduction pathways is done with the help of adaptor proteins that are non-enzymatic in function and that serve as a scaffold for various protein–protein interactions. This process aids in connecting the proximal to distal signaling... (More)
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes with the help of specific transcription factors. These signaling networks propagate with the help of various effector enzymes, such as kinases, phosphatases, and phospholipases. Integration of these disparate signal transduction pathways is done with the help of adaptor proteins that are non-enzymatic in function and that serve as a scaffold for various protein–protein interactions. This process aids in connecting the proximal to distal signaling pathways, thereby contributing to the full activation of T cells. This review provides a comprehensive snapshot of the various molecules involved in regulating T cell receptor signaling, covering both enzymes and adaptors, and will discuss their role in human disease. (Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Signal Transduction and Targeted Therapy
volume
6
issue
1
article number
412
publisher
Springer Nature
external identifiers
  • pmid:34897277
  • scopus:85121048530
ISSN
2059-3635
DOI
10.1038/s41392-021-00823-w
language
English
LU publication?
yes
id
fcce3fdb-b324-4582-a554-f641fe4e57f9
date added to LUP
2021-12-17 15:15:37
date last changed
2021-12-27 07:53:51
@article{fcce3fdb-b324-4582-a554-f641fe4e57f9,
  abstract     = {Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes with the help of specific transcription factors. These signaling networks propagate with the help of various effector enzymes, such as kinases, phosphatases, and phospholipases. Integration of these disparate signal transduction pathways is done with the help of adaptor proteins that are non-enzymatic in function and that serve as a scaffold for various protein–protein interactions. This process aids in connecting the proximal to distal signaling pathways, thereby contributing to the full activation of T cells. This review provides a comprehensive snapshot of the various molecules involved in regulating T cell receptor signaling, covering both enzymes and adaptors, and will discuss their role in human disease.},
  author       = {Shah, Kinjal and Al-Haidari, Amr and Sun, Jianmin and Kazi, Julhash U.},
  issn         = {2059-3635},
  language     = {eng},
  number       = {1},
  publisher    = {Springer Nature},
  series       = {Signal Transduction and Targeted Therapy},
  title        = {T cell receptor (TCR) signaling in health and disease},
  url          = {http://dx.doi.org/10.1038/s41392-021-00823-w},
  doi          = {10.1038/s41392-021-00823-w},
  volume       = {6},
  year         = {2021},
}