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Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men.

Brokken, Leon LU ; Rylander, Lars LU ; Jönsson, Bo A LU ; Spanò, M ; Pedersen, H S ; Ludwicki, J K ; Zviezdai, V ; Bizzaro, D ; Manicardi, G C and Toft, G , et al. (2013) In Molecular and Cellular Endocrinology 370(1-2). p.163-171
Abstract
Recently the dogma that there is an inverse linear association between androgen receptor (AR) CAG and GGN polymorphisms and receptor activity has been challenged. We analysed the pattern of association between 21 male reproductive phenotypes and AR CAG/GGN repeat lengths in 557 proven-fertile men. A linear association was only found between sperm DNA fragmentation index (DFI) and CAG length, and between inhibin B and GGN length. Men with longer CAG then the reference (22-24), had higher oestradiol levels, whereas men with shorter CAG stretches had a higher DFI and a higher proportion of Fas-positive germ cells. Subjects with either short or long CAG had increased seminal levels of prostate-specific antigen and neutral α-glucosidase... (More)
Recently the dogma that there is an inverse linear association between androgen receptor (AR) CAG and GGN polymorphisms and receptor activity has been challenged. We analysed the pattern of association between 21 male reproductive phenotypes and AR CAG/GGN repeat lengths in 557 proven-fertile men. A linear association was only found between sperm DNA fragmentation index (DFI) and CAG length, and between inhibin B and GGN length. Men with longer CAG then the reference (22-24), had higher oestradiol levels, whereas men with shorter CAG stretches had a higher DFI and a higher proportion of Fas-positive germ cells. Subjects with either short or long CAG had increased seminal levels of prostate-specific antigen and neutral α-glucosidase activity. Compared to men with the median GGN length of 23, those with shorter GGN repeats had higher levels of inhibin B, higher proportions of normal and progressive sperm, and a higher fraction of Fas-positive sperm, while men with longer GGN had higher oestradiol levels. These data indicate that at least for some markers of male reproductive function the association with CAG or GGN repeat length is curvilinear. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Molecular and Cellular Endocrinology
volume
370
issue
1-2
pages
163 - 171
publisher
Elsevier
external identifiers
  • wos:000319548200017
  • pmid:23510718
  • scopus:84876379966
  • pmid:23510718
ISSN
1872-8057
DOI
10.1016/j.mce.2013.03.005
language
English
LU publication?
yes
id
fcf9b795-f465-4da1-a4a0-ba51f55cbed4 (old id 3627935)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23510718?dopt=Abstract
date added to LUP
2016-04-01 09:51:34
date last changed
2020-01-05 03:20:35
@article{fcf9b795-f465-4da1-a4a0-ba51f55cbed4,
  abstract     = {Recently the dogma that there is an inverse linear association between androgen receptor (AR) CAG and GGN polymorphisms and receptor activity has been challenged. We analysed the pattern of association between 21 male reproductive phenotypes and AR CAG/GGN repeat lengths in 557 proven-fertile men. A linear association was only found between sperm DNA fragmentation index (DFI) and CAG length, and between inhibin B and GGN length. Men with longer CAG then the reference (22-24), had higher oestradiol levels, whereas men with shorter CAG stretches had a higher DFI and a higher proportion of Fas-positive germ cells. Subjects with either short or long CAG had increased seminal levels of prostate-specific antigen and neutral α-glucosidase activity. Compared to men with the median GGN length of 23, those with shorter GGN repeats had higher levels of inhibin B, higher proportions of normal and progressive sperm, and a higher fraction of Fas-positive sperm, while men with longer GGN had higher oestradiol levels. These data indicate that at least for some markers of male reproductive function the association with CAG or GGN repeat length is curvilinear.},
  author       = {Brokken, Leon and Rylander, Lars and Jönsson, Bo A and Spanò, M and Pedersen, H S and Ludwicki, J K and Zviezdai, V and Bizzaro, D and Manicardi, G C and Toft, G and Bonde, J P and Giwercman, Aleksander and Giwercman, Yvonne},
  issn         = {1872-8057},
  language     = {eng},
  number       = {1-2},
  pages        = {163--171},
  publisher    = {Elsevier},
  series       = {Molecular and Cellular Endocrinology},
  title        = {Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men.},
  url          = {https://lup.lub.lu.se/search/ws/files/1326655/3812582.pdf},
  doi          = {10.1016/j.mce.2013.03.005},
  volume       = {370},
  year         = {2013},
}