Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men.
Brokken, Leon LU ; Rylander, Lars LU
; Jönsson, Bo A
LU
; Spanò, M
; Pedersen, H S
; Ludwicki, J K
; Zviezdai, V
; Bizzaro, D
; Manicardi, G C
and Toft, G
, et al.
(2013)
In Molecular and Cellular Endocrinology
370(1-2).
p.163-171
- Abstract
- Recently the dogma that there is an inverse linear association between androgen receptor (AR) CAG and GGN polymorphisms and receptor activity has been challenged. We analysed the pattern of association between 21 male reproductive phenotypes and AR CAG/GGN repeat lengths in 557 proven-fertile men. A linear association was only found between sperm DNA fragmentation index (DFI) and CAG length, and between inhibin B and GGN length. Men with longer CAG then the reference (22-24), had higher oestradiol levels, whereas men with shorter CAG stretches had a higher DFI and a higher proportion of Fas-positive germ cells. Subjects with either short or long CAG had increased seminal levels of prostate-specific antigen and neutral α-glucosidase... (More)
- Recently the dogma that there is an inverse linear association between androgen receptor (AR) CAG and GGN polymorphisms and receptor activity has been challenged. We analysed the pattern of association between 21 male reproductive phenotypes and AR CAG/GGN repeat lengths in 557 proven-fertile men. A linear association was only found between sperm DNA fragmentation index (DFI) and CAG length, and between inhibin B and GGN length. Men with longer CAG then the reference (22-24), had higher oestradiol levels, whereas men with shorter CAG stretches had a higher DFI and a higher proportion of Fas-positive germ cells. Subjects with either short or long CAG had increased seminal levels of prostate-specific antigen and neutral α-glucosidase activity. Compared to men with the median GGN length of 23, those with shorter GGN repeats had higher levels of inhibin B, higher proportions of normal and progressive sperm, and a higher fraction of Fas-positive sperm, while men with longer GGN had higher oestradiol levels. These data indicate that at least for some markers of male reproductive function the association with CAG or GGN repeat length is curvilinear. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3627935
- author
- Brokken, Leon
LU
; Rylander, Lars
LU
; Jönsson, Bo A
LU
; Spanò, M
; Pedersen, H S
; Ludwicki, J K
; Zviezdai, V
; Bizzaro, D
; Manicardi, G C
and Toft, G
, et al. (More)
- Brokken, Leon
LU
; Rylander, Lars
LU
; Jönsson, Bo A
LU
; Spanò, M
; Pedersen, H S
; Ludwicki, J K
; Zviezdai, V
; Bizzaro, D
; Manicardi, G C
; Toft, G
; Bonde, J P
; Giwercman, Aleksander
LU
and Giwercman, Yvonne
LU
(Less)
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Molecular and Cellular Endocrinology
- volume
- 370
- issue
- 1-2
- pages
- 163 - 171
- publisher
- Elsevier
- external identifiers
-
- wos:000319548200017
- pmid:23510718
- scopus:84876379966
- pmid:23510718
- ISSN
- 1872-8057
- DOI
- 10.1016/j.mce.2013.03.005
- language
- English
- LU publication?
- yes
- id
- fcf9b795-f465-4da1-a4a0-ba51f55cbed4 (old id 3627935)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23510718?dopt=Abstract
- date added to LUP
- 2016-04-01 09:51:34
- date last changed
- 2022-04-03 23:58:28
@article{fcf9b795-f465-4da1-a4a0-ba51f55cbed4,
abstract = {{Recently the dogma that there is an inverse linear association between androgen receptor (AR) CAG and GGN polymorphisms and receptor activity has been challenged. We analysed the pattern of association between 21 male reproductive phenotypes and AR CAG/GGN repeat lengths in 557 proven-fertile men. A linear association was only found between sperm DNA fragmentation index (DFI) and CAG length, and between inhibin B and GGN length. Men with longer CAG then the reference (22-24), had higher oestradiol levels, whereas men with shorter CAG stretches had a higher DFI and a higher proportion of Fas-positive germ cells. Subjects with either short or long CAG had increased seminal levels of prostate-specific antigen and neutral α-glucosidase activity. Compared to men with the median GGN length of 23, those with shorter GGN repeats had higher levels of inhibin B, higher proportions of normal and progressive sperm, and a higher fraction of Fas-positive sperm, while men with longer GGN had higher oestradiol levels. These data indicate that at least for some markers of male reproductive function the association with CAG or GGN repeat length is curvilinear.}},
author = {{Brokken, Leon and Rylander, Lars and Jönsson, Bo A and Spanò, M and Pedersen, H S and Ludwicki, J K and Zviezdai, V and Bizzaro, D and Manicardi, G C and Toft, G and Bonde, J P and Giwercman, Aleksander and Giwercman, Yvonne}},
issn = {{1872-8057}},
language = {{eng}},
number = {{1-2}},
pages = {{163--171}},
publisher = {{Elsevier}},
series = {{Molecular and Cellular Endocrinology}},
title = {{Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men.}},
url = {{https://lup.lub.lu.se/search/files/1326655/3812582.pdf}},
doi = {{10.1016/j.mce.2013.03.005}},
volume = {{370}},
year = {{2013}},
}