Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

RIFM fragrance ingredient safety assessment, isobutyl alcohol, CAS Registry Number 78-83-1

Api, A. M. ; Belmonte, F. ; Belsito, D. ; Biserta, S. ; Botelho, D. ; Bruze, M. LU ; Burton, G. A. ; Buschmann, J. ; Cancellieri, M. A. and Dagli, M. L. , et al. (2019) In Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 134.
Abstract

The existing information supports the use of this material as described in this safety assessment. Isobutyl alcohol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that isobutyl alcohol is not genotoxic. Data on isobutyl alcohol provide a calculated MOE >100 for the repeated dose toxicity and reproductive toxicity endpoints. Data from read-across material isoamyl alcohol (CAS # 123-51-3) show that there are no safety concerns for isobutyl alcohol for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on UV... (More)

The existing information supports the use of this material as described in this safety assessment. Isobutyl alcohol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that isobutyl alcohol is not genotoxic. Data on isobutyl alcohol provide a calculated MOE >100 for the repeated dose toxicity and reproductive toxicity endpoints. Data from read-across material isoamyl alcohol (CAS # 123-51-3) show that there are no safety concerns for isobutyl alcohol for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; isobutyl alcohol is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the TTC for a Cramer Class I material and the exposure to isobutyl alcohol is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; isobutyl alcohol was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Developmental, and Reproductive, Environmental Safety, Genotoxicity, Local, Phototoxicity/Photoallergenicity, Repeated Dose, Respiratory Toxicity, Skin Sensitization, Toxicity
in
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
volume
134
article number
110999
publisher
Elsevier
external identifiers
  • pmid:31783104
  • scopus:85077174368
ISSN
1873-6351
DOI
10.1016/j.fct.2019.110999
language
English
LU publication?
no
id
fdcc7a51-9a62-47ec-9a3c-24258d151d12
date added to LUP
2020-01-10 14:38:51
date last changed
2022-04-18 20:10:26
@article{fdcc7a51-9a62-47ec-9a3c-24258d151d12,
  abstract     = {{<p>The existing information supports the use of this material as described in this safety assessment. Isobutyl alcohol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that isobutyl alcohol is not genotoxic. Data on isobutyl alcohol provide a calculated MOE &gt;100 for the repeated dose toxicity and reproductive toxicity endpoints. Data from read-across material isoamyl alcohol (CAS # 123-51-3) show that there are no safety concerns for isobutyl alcohol for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; isobutyl alcohol is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the TTC for a Cramer Class I material and the exposure to isobutyl alcohol is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; isobutyl alcohol was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are &lt;1.</p>}},
  author       = {{Api, A. M. and Belmonte, F. and Belsito, D. and Biserta, S. and Botelho, D. and Bruze, M. and Burton, G. A. and Buschmann, J. and Cancellieri, M. A. and Dagli, M. L. and Date, M. and Dekant, W. and Deodhar, C. and Fryer, A. D. and Gadhia, S. and Jones, L. and Joshi, K. and Lapczynski, A. and Lavelle, M. and Liebler, D. C. and Na, M. and O'Brien, D. and Patel, A. and Penning, T. M. and Ritacco, G. and Rodriguez-Ropero, F. and Romine, J. and Sadekar, N. and Salvito, D. and Schultz, T. W. and Sipes, I. G. and Sullivan, G. and Thakkar, Y. and Tokura, Y. and Tsang, S.}},
  issn         = {{1873-6351}},
  keywords     = {{Developmental, and Reproductive; Environmental Safety; Genotoxicity; Local; Phototoxicity/Photoallergenicity; Repeated Dose; Respiratory Toxicity; Skin Sensitization; Toxicity}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association}},
  title        = {{RIFM fragrance ingredient safety assessment, isobutyl alcohol, CAS Registry Number 78-83-1}},
  url          = {{http://dx.doi.org/10.1016/j.fct.2019.110999}},
  doi          = {{10.1016/j.fct.2019.110999}},
  volume       = {{134}},
  year         = {{2019}},
}