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The Potential of Dosimetry and the Visualization of Microbeam Arrays in NIPAM Gel at the PETRA III Synchrotron

Breslin, Thomas LU ; Kügele, Malin LU orcid ; de Rover, Vincent ; Fiedler, Stefan ; Lindner, Tobias ; Klingenberg, Johannes ; Faria, Guilherme Abreu ; Frerker, Bernd ; Nuesken, Frank and Ceberg, Sofie LU , et al. (2025) In Gels 11(10).
Abstract

Spatially fractionated radiotherapy (SFRT) is emerging as a powerful tool in cancer therapy for patients who are ineligible for treatment with clinically established irradiation techniques. Microbeam radiotherapy (MRT) is characterized by spatial dose fractionation in the micrometre range. This presents challenges in both treatment planning and dosimetry. While a dosimetry system with a spatial resolution of 10 µm and an option for real-time readout already exists, this system can only record dose in a very small volume. Thus, we are exploring dosimetry in an N-isopropylacrylamide (NIPAM) gel as an option for 3D dose visualization and, potentially, also three-dimensional dosimetry in larger volumes. In the current study, we have... (More)

Spatially fractionated radiotherapy (SFRT) is emerging as a powerful tool in cancer therapy for patients who are ineligible for treatment with clinically established irradiation techniques. Microbeam radiotherapy (MRT) is characterized by spatial dose fractionation in the micrometre range. This presents challenges in both treatment planning and dosimetry. While a dosimetry system with a spatial resolution of 10 µm and an option for real-time readout already exists, this system can only record dose in a very small volume. Thus, we are exploring dosimetry in an N-isopropylacrylamide (NIPAM) gel as an option for 3D dose visualization and, potentially, also three-dimensional dosimetry in larger volumes. In the current study, we have recorded the geometric patterns of single- and multiport irradiation with microbeam arrays in NIPAM gel. Data for 3D dose distribution was acquired in a 7T small animal MRI scanner. We found that the resolution of the gel is well suited for a detailed 3D visualization of microbeam patterns even in complex multiport geometries, similar to that of radiochromic film, which is well established for recording 2D dose distribution in MRT. The results suggest that a dose–response calibration is required for reliable quantitative dosimetry.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
3D visualization, beam geometry, dosimetry, microbeam radiotherapy (MRT), MRI, NIPAM gel, spatially fractionated radiotherapy
in
Gels
volume
11
issue
10
article number
814
publisher
MDPI AG
external identifiers
  • pmid:41149419
  • scopus:105020045012
ISSN
2310-2861
DOI
10.3390/gels11100814
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 by the authors.
id
fe745447-e73e-4cc2-8ea4-acc8b3605b7c
date added to LUP
2025-12-17 14:19:14
date last changed
2025-12-31 15:14:59
@article{fe745447-e73e-4cc2-8ea4-acc8b3605b7c,
  abstract     = {{<p>Spatially fractionated radiotherapy (SFRT) is emerging as a powerful tool in cancer therapy for patients who are ineligible for treatment with clinically established irradiation techniques. Microbeam radiotherapy (MRT) is characterized by spatial dose fractionation in the micrometre range. This presents challenges in both treatment planning and dosimetry. While a dosimetry system with a spatial resolution of 10 µm and an option for real-time readout already exists, this system can only record dose in a very small volume. Thus, we are exploring dosimetry in an N-isopropylacrylamide (NIPAM) gel as an option for 3D dose visualization and, potentially, also three-dimensional dosimetry in larger volumes. In the current study, we have recorded the geometric patterns of single- and multiport irradiation with microbeam arrays in NIPAM gel. Data for 3D dose distribution was acquired in a 7T small animal MRI scanner. We found that the resolution of the gel is well suited for a detailed 3D visualization of microbeam patterns even in complex multiport geometries, similar to that of radiochromic film, which is well established for recording 2D dose distribution in MRT. The results suggest that a dose–response calibration is required for reliable quantitative dosimetry.</p>}},
  author       = {{Breslin, Thomas and Kügele, Malin and de Rover, Vincent and Fiedler, Stefan and Lindner, Tobias and Klingenberg, Johannes and Faria, Guilherme Abreu and Frerker, Bernd and Nuesken, Frank and Ceberg, Sofie and Ceberg, Crister and Lerch, Michael and Hildebrandt, Guido and Schültke, Elisabeth}},
  issn         = {{2310-2861}},
  keywords     = {{3D visualization; beam geometry; dosimetry; microbeam radiotherapy (MRT); MRI; NIPAM gel; spatially fractionated radiotherapy}},
  language     = {{eng}},
  number       = {{10}},
  publisher    = {{MDPI AG}},
  series       = {{Gels}},
  title        = {{The Potential of Dosimetry and the Visualization of Microbeam Arrays in NIPAM Gel at the PETRA III Synchrotron}},
  url          = {{http://dx.doi.org/10.3390/gels11100814}},
  doi          = {{10.3390/gels11100814}},
  volume       = {{11}},
  year         = {{2025}},
}