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Cerebrospinal fluid biomarker results in relation to neuropathological dementia diagnoses.

Brunnström, Hans LU ; Rawshani, Nina; Zetterberg, Henrik; Blennow, Kaj; Minthon, Lennart LU ; Passant, Ulla LU and Englund, Elisabet LU (2010) In Alzheimer's & Dementia 6(2). p.104-109
Abstract
BACKGROUND: Clinical dementia diagnoses are not always consistent with neuropathological findings. As correct diagnosis is important for treatment and care, new diagnostic possibilities for dementia are in demand. Cerebrospinal fluid biomarkers should ideally be able to identify ongoing processes in the brain, but need to be further compared with neuropathological findings for evaluation of their diagnostic validity. METHODS: This study included 43 patients with a clinical dementia disorder. All patients were neuropathologically examined at the University Hospital in Lund, Sweden, during the years 2001-2008, and all had a lumbar puncture carried out as part of the clinical investigation during the time of cognitive impairment. RESULTS: Of... (More)
BACKGROUND: Clinical dementia diagnoses are not always consistent with neuropathological findings. As correct diagnosis is important for treatment and care, new diagnostic possibilities for dementia are in demand. Cerebrospinal fluid biomarkers should ideally be able to identify ongoing processes in the brain, but need to be further compared with neuropathological findings for evaluation of their diagnostic validity. METHODS: This study included 43 patients with a clinical dementia disorder. All patients were neuropathologically examined at the University Hospital in Lund, Sweden, during the years 2001-2008, and all had a lumbar puncture carried out as part of the clinical investigation during the time of cognitive impairment. RESULTS: Of eight patients, five with Alzheimer's disease had elevated total tau protein (T-tau) and decreased amyloid beta 1-42 protein (Abeta42), while both values for the other three patients were normal. Slightly elevated T-tau and/or decreased Abeta42 were also seen in several patients with other dementia diagnoses such as Lewy body disease, frontotemporal lobar degeneration and vascular dementia. Furthermore, T-tau levels did not differ markedly between patients with morphologically tau-positive and tau-negative frontotemporal lobar degeneration. Also, seven of nine patients with Creutzfeldt-Jacob disease exhibited pronounced elevation in T-tau concentration. CONCLUSION: From this rather limited study, being the first of its kind in Sweden, we may conclude that there is no perfect concordance between cerebrospinal fluid biomarker levels and pathological findings, which should be taken into account in the clinical diagnostic setting. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Alzheimer's & Dementia
volume
6
issue
2
pages
104 - 109
publisher
Elsevier
external identifiers
  • wos:000276576400003
  • pmid:20298970
  • scopus:77949338057
ISSN
1552-5279
DOI
10.1016/j.jalz.2009.12.005
language
English
LU publication?
yes
id
ff53af36-c9b9-4e68-97a2-997eb85d4456 (old id 1581856)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20298970?dopt=Abstract
date added to LUP
2010-04-07 21:34:01
date last changed
2018-07-08 04:05:49
@article{ff53af36-c9b9-4e68-97a2-997eb85d4456,
  abstract     = {BACKGROUND: Clinical dementia diagnoses are not always consistent with neuropathological findings. As correct diagnosis is important for treatment and care, new diagnostic possibilities for dementia are in demand. Cerebrospinal fluid biomarkers should ideally be able to identify ongoing processes in the brain, but need to be further compared with neuropathological findings for evaluation of their diagnostic validity. METHODS: This study included 43 patients with a clinical dementia disorder. All patients were neuropathologically examined at the University Hospital in Lund, Sweden, during the years 2001-2008, and all had a lumbar puncture carried out as part of the clinical investigation during the time of cognitive impairment. RESULTS: Of eight patients, five with Alzheimer's disease had elevated total tau protein (T-tau) and decreased amyloid beta 1-42 protein (Abeta42), while both values for the other three patients were normal. Slightly elevated T-tau and/or decreased Abeta42 were also seen in several patients with other dementia diagnoses such as Lewy body disease, frontotemporal lobar degeneration and vascular dementia. Furthermore, T-tau levels did not differ markedly between patients with morphologically tau-positive and tau-negative frontotemporal lobar degeneration. Also, seven of nine patients with Creutzfeldt-Jacob disease exhibited pronounced elevation in T-tau concentration. CONCLUSION: From this rather limited study, being the first of its kind in Sweden, we may conclude that there is no perfect concordance between cerebrospinal fluid biomarker levels and pathological findings, which should be taken into account in the clinical diagnostic setting.},
  author       = {Brunnström, Hans and Rawshani, Nina and Zetterberg, Henrik and Blennow, Kaj and Minthon, Lennart and Passant, Ulla and Englund, Elisabet},
  issn         = {1552-5279},
  language     = {eng},
  number       = {2},
  pages        = {104--109},
  publisher    = {Elsevier},
  series       = {Alzheimer's & Dementia},
  title        = {Cerebrospinal fluid biomarker results in relation to neuropathological dementia diagnoses.},
  url          = {http://dx.doi.org/10.1016/j.jalz.2009.12.005},
  volume       = {6},
  year         = {2010},
}