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- 2016
- Two-step production of monoamines in monoenzymatic cells in the spinal cord : A different control strategy of neurotransmitter supply?
- 2014
- Novel strategies for enzyme replacement with gene therapy in models of Parkinson’s disease
- 2012
- Dysregulated dopamine storage increases the vulnerability to alpha-synuclein in nigral neurons
-
Key factors determining the efficacy of gene therapy for continuous DOPA delivery in the Parkinsonian brain
Cederfjäll, Erik LU ; Sahin, Gurdal LU
and
Kirik, Deniz
LU
(2012)
In Neurobiology of Disease
48(2).
p.222-227
Mark
- 2010
- Modeling pathophysiological aspects of Parkinson’s disease: Manipulating DA handling and alpha-synuclein expression in the nigrostriatal pathway using viral vectors
- 2009
- Gene therapy by enzyme replacement for Parkinson’s disease Optimization of continuous DOPA delivery and development of a candidate vector for clinical application
- Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats
- Positron Emission Tomography Imaging Demonstrates Correlation between Behavioral Recovery and Correction of Dopamine Neurotransmission after Gene Therapy
- 2007
- Cell and Gene Therapy for Parkinson's Disease: Therapeutic Effect and Modulation of Dyskinesias in the 6-OHDA Rat Model
- 2006
- Induction of dopaminergic neurons from growth factor expanded neural stem/progenitor cell cultures derived from human first trimester forebrain.
- Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression.
- 2005
- Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice.
-
Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors.
Carlsson, Thomas LU ; Winkler, Christian LU ; Burger, Corinna ; Muzyczka, Nicholas ; Mandel, Ronald J ; Cenci Nilsson, Angela LU
;
Björklund, Anders
LU
and
Kirik, Deniz
LU
(2005)
In Brain
128(3).
p.559-569
Mark
-
Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections.
Thompson, Lachlan LU ; Barraud, Perrine LU ; Andersson, Elin LU ; Kirik, Deniz LU and Björklund, Anders LU
(2005)
In J Neurosci
25(27).
p.6467-6477
Mark
- 2004
- GDNF gene delivery in an animal model of Parkinson's disease. Long-term effects on intact, injured and transplanted dopamine neurons using lentiviral gene transfer