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An approach to diketone-galectin-3 inhibitor

Hoang, Shaun LU (2011) KEMK01 20111
Department of Chemistry
Abstract
In many biological mechanisms galectins play important roles. The galectins are important in
inflammation, immunologic response and cancer. A key function of galectins is cross-linking
of their glycoprotein ligands which are connected with the biological activities. Carbohydrate
recognition domains (CRD) are responsible for the cross-linking. The galectin CRDs are
divided into subsites A-E and it has been discovered that there is a binding affinity for Arg144
in subsite A-B of galectin-3. In a recent study they discovered that diacetyl is binding
covalently to N-α-acetylarginine. It is interesting to synthesize a galectin inhibitor with
diketone functionality and test if it binds to Arg144.
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author
Hoang, Shaun LU
supervisor
organization
course
KEMK01 20111
year
type
M2 - Bachelor Degree
subject
keywords
Organisk kemi
language
English
id
2862841
date added to LUP
2012-08-14 14:04:31
date last changed
2012-08-14 14:04:31
@misc{2862841,
  abstract     = {In many biological mechanisms galectins play important roles. The galectins are important in
inflammation, immunologic response and cancer. A key function of galectins is cross-linking
of their glycoprotein ligands which are connected with the biological activities. Carbohydrate
recognition domains (CRD) are responsible for the cross-linking. The galectin CRDs are
divided into subsites A-E and it has been discovered that there is a binding affinity for Arg144
in subsite A-B of galectin-3. In a recent study they discovered that diacetyl is binding
covalently to N-α-acetylarginine. It is interesting to synthesize a galectin inhibitor with
diketone functionality and test if it binds to Arg144.},
  author       = {Hoang, Shaun},
  keyword      = {Organisk kemi},
  language     = {eng},
  note         = {Student Paper},
  title        = {An approach to diketone-galectin-3 inhibitor},
  year         = {2011},
}