An approach to diketone-galectin-3 inhibitor
(2011) KEMK01 20111Department of Chemistry
- Abstract
- In many biological mechanisms galectins play important roles. The galectins are important in
inflammation, immunologic response and cancer. A key function of galectins is cross-linking
of their glycoprotein ligands which are connected with the biological activities. Carbohydrate
recognition domains (CRD) are responsible for the cross-linking. The galectin CRDs are
divided into subsites A-E and it has been discovered that there is a binding affinity for Arg144
in subsite A-B of galectin-3. In a recent study they discovered that diacetyl is binding
covalently to N-α-acetylarginine. It is interesting to synthesize a galectin inhibitor with
diketone functionality and test if it binds to Arg144.
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/student-papers/record/2862841
- author
- Hoang, Shaun LU
- supervisor
- organization
- course
- KEMK01 20111
- year
- 2011
- type
- M2 - Bachelor Degree
- subject
- keywords
- Organisk kemi
- language
- English
- id
- 2862841
- date added to LUP
- 2012-08-14 14:04:31
- date last changed
- 2012-08-14 14:04:31
@misc{2862841, abstract = {{In many biological mechanisms galectins play important roles. The galectins are important in inflammation, immunologic response and cancer. A key function of galectins is cross-linking of their glycoprotein ligands which are connected with the biological activities. Carbohydrate recognition domains (CRD) are responsible for the cross-linking. The galectin CRDs are divided into subsites A-E and it has been discovered that there is a binding affinity for Arg144 in subsite A-B of galectin-3. In a recent study they discovered that diacetyl is binding covalently to N-α-acetylarginine. It is interesting to synthesize a galectin inhibitor with diketone functionality and test if it binds to Arg144.}}, author = {{Hoang, Shaun}}, language = {{eng}}, note = {{Student Paper}}, title = {{An approach to diketone-galectin-3 inhibitor}}, year = {{2011}}, }