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Enzymatically Produced Liquid Crystalline Phases for Encapsulation and Extended Release of Ibuprofen and Aspartame

Jiang, Xiaotong LU (2025) KBTM01 20251
Biotechnology (MSc)
Biotechnology (M.Sc.Eng.)
Abstract
In order to design and investigate the effects of vegetable oil based enzymatically produced liquid
crystalline phases (LCPs), oat oil with 15% and 50% polar lipids contents (PL15, PL40) and with
different storage conditions were incubated with Lipozyme TL and CalB. PL40 based LCPs were further
investigated incorporating 1-10% aspartame (ASP) or ibuprofen (IBU) and all of the LCPs samples were
analyzed with SAXS to study the nanostructures. GC-FID was used to analyze the lipid ratios of the
original oil sample and the LCPs samples. pH-stat titration experiment was performed to study the effect
of LCPs properties under a controlled pH of 7. In order to study the effect of LCPs in simulated digestion
tract, PL40, coconut oil based... (More)
In order to design and investigate the effects of vegetable oil based enzymatically produced liquid
crystalline phases (LCPs), oat oil with 15% and 50% polar lipids contents (PL15, PL40) and with
different storage conditions were incubated with Lipozyme TL and CalB. PL40 based LCPs were further
investigated incorporating 1-10% aspartame (ASP) or ibuprofen (IBU) and all of the LCPs samples were
analyzed with SAXS to study the nanostructures. GC-FID was used to analyze the lipid ratios of the
original oil sample and the LCPs samples. pH-stat titration experiment was performed to study the effect
of LCPs properties under a controlled pH of 7. In order to study the effect of LCPs in simulated digestion
tract, PL40, coconut oil based samples were studied in simulated intestinal fluid. (Less)
Popular Abstract
Vegetable oils have recently gained attention as potential drug carriers due to their ability to self-assemble
into liquid crystalline phases (LCPs), which have nanostructures that protect the drug from being
degraded and control the release of the drug. In this study, different vegetable oils, mainly oat oils with
different polar lipid contents (PL40 and PL15) were investigated for their ability to form LCPs and
encapsulate aspartame (ASP) and ibuprofen (IBU). The nanostructure, lipid compositions, and
incorporated properties were investigated. Simulated human intestinal digestion experiments were
included to study the drug release effect of LCPs. The vegetable oils produced LCPs showed promising
results of sustained drug release,... (More)
Vegetable oils have recently gained attention as potential drug carriers due to their ability to self-assemble
into liquid crystalline phases (LCPs), which have nanostructures that protect the drug from being
degraded and control the release of the drug. In this study, different vegetable oils, mainly oat oils with
different polar lipid contents (PL40 and PL15) were investigated for their ability to form LCPs and
encapsulate aspartame (ASP) and ibuprofen (IBU). The nanostructure, lipid compositions, and
incorporated properties were investigated. Simulated human intestinal digestion experiments were
included to study the drug release effect of LCPs. The vegetable oils produced LCPs showed promising
results of sustained drug release, and the potential of being drug carriers. (Less)
Please use this url to cite or link to this publication:
author
Jiang, Xiaotong LU
supervisor
organization
course
KBTM01 20251
year
type
H2 - Master's Degree (Two Years)
subject
keywords
LCPs, lipids, structure, ibuprofen, drug release, biotechnology
language
English
id
9213325
date added to LUP
2025-09-30 10:37:49
date last changed
2025-09-30 10:37:49
@misc{9213325,
  abstract     = {{In order to design and investigate the effects of vegetable oil based enzymatically produced liquid
crystalline phases (LCPs), oat oil with 15% and 50% polar lipids contents (PL15, PL40) and with
different storage conditions were incubated with Lipozyme TL and CalB. PL40 based LCPs were further
investigated incorporating 1-10% aspartame (ASP) or ibuprofen (IBU) and all of the LCPs samples were
analyzed with SAXS to study the nanostructures. GC-FID was used to analyze the lipid ratios of the
original oil sample and the LCPs samples. pH-stat titration experiment was performed to study the effect
of LCPs properties under a controlled pH of 7. In order to study the effect of LCPs in simulated digestion
tract, PL40, coconut oil based samples were studied in simulated intestinal fluid.}},
  author       = {{Jiang, Xiaotong}},
  language     = {{eng}},
  note         = {{Student Paper}},
  title        = {{Enzymatically Produced Liquid Crystalline Phases for Encapsulation and Extended Release of Ibuprofen and Aspartame}},
  year         = {{2025}},
}