Rapid short-duration hypothermia with cold saline and endovascular cooling before reperfusion reduces microvascular obstruction and myocardial infarct size.
(2008) In BMC Cardiovascular Disorders 8(Apr 10).- Abstract
- BACKGROUND: The aim of this study was to evaluate the combination of a rapid intravenous infusion of cold saline and endovascular hypothermia in a closed chest pig infarct model. METHODS: Pigs were randomized to pre-reperfusion hypothermia (n = 7), post-reperfusion hypothermia (n = 7) or normothermia (n = 5). A percutaneous coronary intervention balloon was inflated in the left anterior descending artery for 40 min. Hypothermia was started after 25 min of ischemia or immediately after reperfusion by infusion of 1000 ml of 4 degrees C saline and endovascular hypothermia. Area at risk was evaluated by in vivo SPECT. Infarct size was evaluated by ex vivo MRI. RESULTS: Pre-reperfusion hypothermia reduced infarct size/area at risk by 43% (46... (More)
- BACKGROUND: The aim of this study was to evaluate the combination of a rapid intravenous infusion of cold saline and endovascular hypothermia in a closed chest pig infarct model. METHODS: Pigs were randomized to pre-reperfusion hypothermia (n = 7), post-reperfusion hypothermia (n = 7) or normothermia (n = 5). A percutaneous coronary intervention balloon was inflated in the left anterior descending artery for 40 min. Hypothermia was started after 25 min of ischemia or immediately after reperfusion by infusion of 1000 ml of 4 degrees C saline and endovascular hypothermia. Area at risk was evaluated by in vivo SPECT. Infarct size was evaluated by ex vivo MRI. RESULTS: Pre-reperfusion hypothermia reduced infarct size/area at risk by 43% (46 +/- 8%) compared to post-reperfusion hypothermia (80 +/- 6%, p < 0.05) and by 39% compared to normothermia (75 +/- 5%, p < 0.05). Pre-reperfusion hypothermia infarctions were patchier in appearance with scattered islands of viable myocardium. Pre-reperfusion hypothermia abolished (0%, p < 0.001), and post-reperfusion hypothermia significantly reduced microvascular obstruction (10.3 +/- 5%; p < 0.05), compared to normothermia: (30.2 +/- 5%). CONCLUSION: Rapid hypothermia with cold saline and endovascular cooling before reperfusion reduces myocardial infarct size and microvascular obstruction. A novel finding is that hypothermia at the onset of reperfusion reduces microvascular obstruction without reducing myocardial infarct size. Intravenous administration of cold saline combined with endovascular hypothermia provides a method for a rapid induction of hypothermia suggesting a potential clinical application. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1147505
- author
- Götberg, Matthias LU ; Olivecrona, Göran LU ; Engblom, Henrik LU ; Ugander, Martin LU ; vanderPals, Jesper LU ; Heiberg, Einar LU ; Arheden, Håkan LU and Erlinge, David LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- AnimalsDisease Models, AnimalFemaleHemodynamicsHypothermia, Induced*Magnetic Resonance ImagingMaleMyocardial Infarction/diagnosisMyocardial Infarction/physiopathologyMyocardial Infarction/therapy*Myocardial Reperfusion/methods*Myocardial Reperfusion Injury/prevention & control*Random AllocationSwine
- in
- BMC Cardiovascular Disorders
- volume
- 8
- issue
- Apr 10
- article number
- 7
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000266852600001
- pmid:18402663
- scopus:42549129618
- ISSN
- 1471-2261
- DOI
- 10.1186/1471-2261-8-7
- language
- English
- LU publication?
- yes
- id
- ab519760-ae98-4651-8aa3-42472625cf1a (old id 1147505)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18402663?dopt=Abstract
- date added to LUP
- 2016-04-04 09:08:28
- date last changed
- 2022-03-15 17:53:55
@article{ab519760-ae98-4651-8aa3-42472625cf1a, abstract = {{BACKGROUND: The aim of this study was to evaluate the combination of a rapid intravenous infusion of cold saline and endovascular hypothermia in a closed chest pig infarct model. METHODS: Pigs were randomized to pre-reperfusion hypothermia (n = 7), post-reperfusion hypothermia (n = 7) or normothermia (n = 5). A percutaneous coronary intervention balloon was inflated in the left anterior descending artery for 40 min. Hypothermia was started after 25 min of ischemia or immediately after reperfusion by infusion of 1000 ml of 4 degrees C saline and endovascular hypothermia. Area at risk was evaluated by in vivo SPECT. Infarct size was evaluated by ex vivo MRI. RESULTS: Pre-reperfusion hypothermia reduced infarct size/area at risk by 43% (46 +/- 8%) compared to post-reperfusion hypothermia (80 +/- 6%, p < 0.05) and by 39% compared to normothermia (75 +/- 5%, p < 0.05). Pre-reperfusion hypothermia infarctions were patchier in appearance with scattered islands of viable myocardium. Pre-reperfusion hypothermia abolished (0%, p < 0.001), and post-reperfusion hypothermia significantly reduced microvascular obstruction (10.3 +/- 5%; p < 0.05), compared to normothermia: (30.2 +/- 5%). CONCLUSION: Rapid hypothermia with cold saline and endovascular cooling before reperfusion reduces myocardial infarct size and microvascular obstruction. A novel finding is that hypothermia at the onset of reperfusion reduces microvascular obstruction without reducing myocardial infarct size. Intravenous administration of cold saline combined with endovascular hypothermia provides a method for a rapid induction of hypothermia suggesting a potential clinical application.}}, author = {{Götberg, Matthias and Olivecrona, Göran and Engblom, Henrik and Ugander, Martin and vanderPals, Jesper and Heiberg, Einar and Arheden, Håkan and Erlinge, David}}, issn = {{1471-2261}}, keywords = {{AnimalsDisease Models; AnimalFemaleHemodynamicsHypothermia; Induced*Magnetic Resonance ImagingMaleMyocardial Infarction/diagnosisMyocardial Infarction/physiopathologyMyocardial Infarction/therapy*Myocardial Reperfusion/methods*Myocardial Reperfusion Injury/prevention & control*Random AllocationSwine}}, language = {{eng}}, number = {{Apr 10}}, publisher = {{BioMed Central (BMC)}}, series = {{BMC Cardiovascular Disorders}}, title = {{Rapid short-duration hypothermia with cold saline and endovascular cooling before reperfusion reduces microvascular obstruction and myocardial infarct size.}}, url = {{https://lup.lub.lu.se/search/files/5242822/1150105.pdf}}, doi = {{10.1186/1471-2261-8-7}}, volume = {{8}}, year = {{2008}}, }