Relationship between increased relative birthweight and infections during pregnancy in children with a high-risk diabetes HLA genotype.
Larsson, Helena LU ; Lynch, Kristian LU ; Lernmark, Barbro LU ; Hansson, Gertie LU ; Lernmark, Åke LU
; Ivarsson, Sten
LU
and Carlsson, Annelie
LU
(2007)
In Diabetologia
50(6).
p.1161-1169
- Abstract
- Aims/hypothesis Children with high-risk type 1 diabetes HLA genotype have increased risk of high relative birthweight (HrBW), while cord blood islet autoantibodies decrease the risk. As gestational infections may affect offspring type 1 diabetes risk, the aims were to test whether: (1) children of mothers reporting gestational infections have increased HrBW; (2) gestational infections explain islet autoantibody reduction of HrBW; and (3) gestational infections affect the association between HLA and HrBW. Subjects and methods HLA genotypes and autoantibodies to glutamic acid decarboxylase, insulinoma-associated protein 2 and insulin were determined in cord blood of children born to non-diabetic mothers in the Diabetes Prediction in Skane... (More)
- Aims/hypothesis Children with high-risk type 1 diabetes HLA genotype have increased risk of high relative birthweight (HrBW), while cord blood islet autoantibodies decrease the risk. As gestational infections may affect offspring type 1 diabetes risk, the aims were to test whether: (1) children of mothers reporting gestational infections have increased HrBW; (2) gestational infections explain islet autoantibody reduction of HrBW; and (3) gestational infections affect the association between HLA and HrBW. Subjects and methods HLA genotypes and autoantibodies to glutamic acid decarboxylase, insulinoma-associated protein 2 and insulin were determined in cord blood of children born to non-diabetic mothers in the Diabetes Prediction in Skane (DiPiS) study. Mothers reported gestational infections when the child was 2 months old. Results Fever or gastroenteritis during pregnancy was reported by 2,848/19,756 mothers (14%); 339 in more than one trimester. Children whose mothers reported infections had increased risk of HrBW (p=0.0003), particularly in the absence of cord blood islet autoantibodies (interaction between HrBW, islet autoantibodies and infections, p=0.0005). The effect on HrBW by high-risk HLA-DQ2/8 was aggravated by infections in more than one trimester (odds ratio [OR]=5.24; p=0.003) (interaction; p=0.022). When infections were reported, cord blood islet autoantibodies decreased HrBW (OR=0.34; p=0.0002). Conclusions/intrepretation This study revealed that: (1) gestational fever, gastroenteritis, or both, increased the risk of HrBW; (2) cord blood islet autoantibodies decreased the risk of HrBW only in combination with infections; and (3) infections aggravated the association between HLA-DQ2/8 and HrBW. These data suggest an interaction between HLA, gestational infections, islet autoantibodies and fetal growth. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/167813
- author
- Larsson, Helena
LU
; Lynch, Kristian
LU
; Lernmark, Barbro
LU
; Hansson, Gertie
LU
; Lernmark, Åke
LU
; Ivarsson, Sten
LU
and Carlsson, Annelie
LU
- author collaboration
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- IA-2 autoantibodies, gestational, infections, HLA, GAD65 autoantibodies, gastroenteritis, birthweight, fever, type 1 diabetes, islet autoantibodies, autoantibodies, insulin
- in
- Diabetologia
- volume
- 50
- issue
- 6
- pages
- 1161 - 1169
- publisher
- Springer
- external identifiers
-
- wos:000246271600007
- scopus:34247874558
- ISSN
- 1432-0428
- DOI
- 10.1007/s00125-007-0648-6
- language
- English
- LU publication?
- yes
- id
- be554eb5-29d4-4f72-8fb0-dccb150a78ab (old id 167813)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17406854&dopt=Abstract
- date added to LUP
- 2016-04-01 11:50:10
- date last changed
- 2022-01-26 18:57:58
@article{be554eb5-29d4-4f72-8fb0-dccb150a78ab,
abstract = {{Aims/hypothesis Children with high-risk type 1 diabetes HLA genotype have increased risk of high relative birthweight (HrBW), while cord blood islet autoantibodies decrease the risk. As gestational infections may affect offspring type 1 diabetes risk, the aims were to test whether: (1) children of mothers reporting gestational infections have increased HrBW; (2) gestational infections explain islet autoantibody reduction of HrBW; and (3) gestational infections affect the association between HLA and HrBW. Subjects and methods HLA genotypes and autoantibodies to glutamic acid decarboxylase, insulinoma-associated protein 2 and insulin were determined in cord blood of children born to non-diabetic mothers in the Diabetes Prediction in Skane (DiPiS) study. Mothers reported gestational infections when the child was 2 months old. Results Fever or gastroenteritis during pregnancy was reported by 2,848/19,756 mothers (14%); 339 in more than one trimester. Children whose mothers reported infections had increased risk of HrBW (p=0.0003), particularly in the absence of cord blood islet autoantibodies (interaction between HrBW, islet autoantibodies and infections, p=0.0005). The effect on HrBW by high-risk HLA-DQ2/8 was aggravated by infections in more than one trimester (odds ratio [OR]=5.24; p=0.003) (interaction; p=0.022). When infections were reported, cord blood islet autoantibodies decreased HrBW (OR=0.34; p=0.0002). Conclusions/intrepretation This study revealed that: (1) gestational fever, gastroenteritis, or both, increased the risk of HrBW; (2) cord blood islet autoantibodies decreased the risk of HrBW only in combination with infections; and (3) infections aggravated the association between HLA-DQ2/8 and HrBW. These data suggest an interaction between HLA, gestational infections, islet autoantibodies and fetal growth.}},
author = {{Larsson, Helena and Lynch, Kristian and Lernmark, Barbro and Hansson, Gertie and Lernmark, Åke and Ivarsson, Sten and Carlsson, Annelie}},
issn = {{1432-0428}},
keywords = {{IA-2 autoantibodies; gestational; infections; HLA; GAD65 autoantibodies; gastroenteritis; birthweight; fever; type 1 diabetes; islet autoantibodies; autoantibodies; insulin}},
language = {{eng}},
number = {{6}},
pages = {{1161--1169}},
publisher = {{Springer}},
series = {{Diabetologia}},
title = {{Relationship between increased relative birthweight and infections during pregnancy in children with a high-risk diabetes HLA genotype.}},
url = {{http://dx.doi.org/10.1007/s00125-007-0648-6}},
doi = {{10.1007/s00125-007-0648-6}},
volume = {{50}},
year = {{2007}},
}