Hospital Admissions for Ischemic Stroke: Does Long-Term Exposure to Air Pollution Interact with Major Risk Factors?
(2011) In Cerebrovascular Diseases 31(3). p.284-293- Abstract
- Background: The aim was to investigate whether the effects of major risk factors for ischemic stroke were modified by long-term exposure to air pollution in Scania, southern Sweden. Methods: Cases were defined as first-ever ischemic strokes in patients born between 1923 and 1965 during 2001-2006 (n = 7,244). Data were collected from The Swedish National Stroke Register (Riks-stroke) and the Malmo and Lund Stroke Registers. Population controls were matched on age and sex. Modeled outdoor annual mean NOx concentrations were used as proxy for long-term exposure to air pollution. Heterogeneity across NOx categories was tested for smoking, hypertension, diabetes mellitus, atrial fibrillation and physical inactivity. Data were analyzed as... (More)
- Background: The aim was to investigate whether the effects of major risk factors for ischemic stroke were modified by long-term exposure to air pollution in Scania, southern Sweden. Methods: Cases were defined as first-ever ischemic strokes in patients born between 1923 and 1965 during 2001-2006 (n = 7,244). Data were collected from The Swedish National Stroke Register (Riks-stroke) and the Malmo and Lund Stroke Registers. Population controls were matched on age and sex. Modeled outdoor annual mean NOx concentrations were used as proxy for long-term exposure to air pollution. Heterogeneity across NOx categories was tested for smoking, hypertension, diabetes mellitus, atrial fibrillation and physical inactivity. Data were analyzed as case-control data and to some extent as case-only data, with logistic regression analysis. Results: The case-control odds ratios for ischemic stroke in association with diabetes were 1.3 [95% confidence interval (CI): 1.1-1.6] and 2.0 (95% CI: 1.2-3.4) in the lowest and highest NOx category, respectively (p value for testing heterogeneity across the categories = 0.056). The case-only approach gave further support for the risk associated with diabetes to increase with NOx (p for trend = 0.033). We observed no main effect of mean NOx or any conclusive effect modifications between NOx and smoking, hypertension, atrial fibrillation or physical inactivity. Conclusions: In a low-level air pollution area, the risk for ischemic stroke associated with diabetes seemed to increase with long-term exposure to air pollution. Copyright (C) 2010 S. Karger AG, Basel (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2056764
- author
- Oudin, Anna ; Stromberg, Ulf ; Jakobsson, Kristina ; Stroh, Emilie ; Lindgren, Arne LU ; Norrving, Bo LU ; Pessah-Rasmussen, Hélène LU ; Engström, Gunnar LU and Björk, Jonas LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Ischemic stroke, Air pollution, Diabetes mellitus, Long-term exposure, Effect modification
- in
- Cerebrovascular Diseases
- volume
- 31
- issue
- 3
- pages
- 284 - 293
- publisher
- Karger
- external identifiers
-
- wos:000291816300011
- scopus:78650638012
- ISSN
- 1421-9786
- DOI
- 10.1159/000322600
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neurology, Lund (013027000), Neurology, Malmö (013027010), Cardio-vascular Epidemiology (013241610), Division of Occupational and Environmental Medicine (013078001)
- id
- cebbb8ba-b616-417f-803e-3e0e8de20d15 (old id 2056764)
- date added to LUP
- 2016-04-01 11:09:01
- date last changed
- 2022-01-26 05:50:21
@article{cebbb8ba-b616-417f-803e-3e0e8de20d15,
abstract = {{Background: The aim was to investigate whether the effects of major risk factors for ischemic stroke were modified by long-term exposure to air pollution in Scania, southern Sweden. Methods: Cases were defined as first-ever ischemic strokes in patients born between 1923 and 1965 during 2001-2006 (n = 7,244). Data were collected from The Swedish National Stroke Register (Riks-stroke) and the Malmo and Lund Stroke Registers. Population controls were matched on age and sex. Modeled outdoor annual mean NOx concentrations were used as proxy for long-term exposure to air pollution. Heterogeneity across NOx categories was tested for smoking, hypertension, diabetes mellitus, atrial fibrillation and physical inactivity. Data were analyzed as case-control data and to some extent as case-only data, with logistic regression analysis. Results: The case-control odds ratios for ischemic stroke in association with diabetes were 1.3 [95% confidence interval (CI): 1.1-1.6] and 2.0 (95% CI: 1.2-3.4) in the lowest and highest NOx category, respectively (p value for testing heterogeneity across the categories = 0.056). The case-only approach gave further support for the risk associated with diabetes to increase with NOx (p for trend = 0.033). We observed no main effect of mean NOx or any conclusive effect modifications between NOx and smoking, hypertension, atrial fibrillation or physical inactivity. Conclusions: In a low-level air pollution area, the risk for ischemic stroke associated with diabetes seemed to increase with long-term exposure to air pollution. Copyright (C) 2010 S. Karger AG, Basel}},
author = {{Oudin, Anna and Stromberg, Ulf and Jakobsson, Kristina and Stroh, Emilie and Lindgren, Arne and Norrving, Bo and Pessah-Rasmussen, Hélène and Engström, Gunnar and Björk, Jonas}},
issn = {{1421-9786}},
keywords = {{Ischemic stroke; Air pollution; Diabetes mellitus; Long-term exposure; Effect modification}},
language = {{eng}},
number = {{3}},
pages = {{284--293}},
publisher = {{Karger}},
series = {{Cerebrovascular Diseases}},
title = {{Hospital Admissions for Ischemic Stroke: Does Long-Term Exposure to Air Pollution Interact with Major Risk Factors?}},
url = {{http://dx.doi.org/10.1159/000322600}},
doi = {{10.1159/000322600}},
volume = {{31}},
year = {{2011}},
}