Effect of lactobacilli on paracellular permeability in the gut.
(2011) In Nutrients 3(1). p.104-117- Abstract
- Paracellular permeability is determined by the complex structures of junctions that are located between the epithelial cells. Already in 1996, it was shown that the human probiotic strain Lactobacillus plantarum 299v and the rat-originating strain Lactobacillus reuteri R2LC could reduce this permeability in a methotrexate-induced colitis model in the rat. Subsequently, many animal models and cell culture systems have shown indications that lactobacilli are able to counteract increased paracellular permeability evoked by cytokines, chemicals, infections, or stress. There have been few human studies focusing on the effect of lactobacilli on intestinal paracellular permeability but recently it has been shown that they could influence the... (More)
- Paracellular permeability is determined by the complex structures of junctions that are located between the epithelial cells. Already in 1996, it was shown that the human probiotic strain Lactobacillus plantarum 299v and the rat-originating strain Lactobacillus reuteri R2LC could reduce this permeability in a methotrexate-induced colitis model in the rat. Subsequently, many animal models and cell culture systems have shown indications that lactobacilli are able to counteract increased paracellular permeability evoked by cytokines, chemicals, infections, or stress. There have been few human studies focusing on the effect of lactobacilli on intestinal paracellular permeability but recently it has been shown that they could influence the tight junctions. More precisely, short-term administration of L. plantarum WCSF1 to healthy volunteers increased the relocation of occludin and ZO-1 into the tight junction area between duodenal epithelial cells. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2336252
- author
- Ahrné, Siv LU and Johansson Hagslatt, Marie-Louise
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nutrients
- volume
- 3
- issue
- 1
- pages
- 104 - 117
- publisher
- MDPI AG
- external identifiers
-
- wos:000298239900006
- pmid:22254077
- scopus:79952046775
- pmid:22254077
- ISSN
- 2072-6643
- DOI
- 10.3390/nu3010104
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Applied Nutrition and Food Chemistry (011001300)
- id
- 43f769cc-40ad-4366-b9f9-1c5cb2a676e9 (old id 2336252)
- date added to LUP
- 2016-04-01 13:18:38
- date last changed
- 2023-12-11 13:07:17
@article{43f769cc-40ad-4366-b9f9-1c5cb2a676e9,
abstract = {{Paracellular permeability is determined by the complex structures of junctions that are located between the epithelial cells. Already in 1996, it was shown that the human probiotic strain Lactobacillus plantarum 299v and the rat-originating strain Lactobacillus reuteri R2LC could reduce this permeability in a methotrexate-induced colitis model in the rat. Subsequently, many animal models and cell culture systems have shown indications that lactobacilli are able to counteract increased paracellular permeability evoked by cytokines, chemicals, infections, or stress. There have been few human studies focusing on the effect of lactobacilli on intestinal paracellular permeability but recently it has been shown that they could influence the tight junctions. More precisely, short-term administration of L. plantarum WCSF1 to healthy volunteers increased the relocation of occludin and ZO-1 into the tight junction area between duodenal epithelial cells.}},
author = {{Ahrné, Siv and Johansson Hagslatt, Marie-Louise}},
issn = {{2072-6643}},
language = {{eng}},
number = {{1}},
pages = {{104--117}},
publisher = {{MDPI AG}},
series = {{Nutrients}},
title = {{Effect of lactobacilli on paracellular permeability in the gut.}},
url = {{http://dx.doi.org/10.3390/nu3010104}},
doi = {{10.3390/nu3010104}},
volume = {{3}},
year = {{2011}},
}