Alcohol consumption and mortality in individuals with diabetes mellitus

Sluik, Diewertje; Boeing, Heiner; Bergmann, Manuela M.; Schuetze, Madlen; Teucher, Birgit; Kaaks, Rudolf; Tjonneland, Anne; Overvad, Kim; Arriola, Larraitz; Ardanaz, Eva; Bendinelli, Benedetta; Agnoli, Claudia; Tumino, Rosario; Ricceri, Fulvio; Mattiello, Amalia; Spijkerman, Annemieke M. W.; Beulens, Joline W. J.; Grobbee, Diederick E.; Nilsson, Peter; Melander, Olle; Franks, Paul; Rolandsson, Olov; Riboli, Elio; Gallo, Valentina; Romaguera, Dora; Noethlings, Ute

Alcohol consumption and mortality in individuals with diabetes mellitus

Mark

Sluik, Diewertje ; Boeing, Heiner ; Bergmann, Manuela M. ; Schuetze, Madlen ; Teucher, Birgit ; Kaaks, Rudolf ; Tjonneland, Anne ; Overvad, Kim ; Arriola, Larraitz and Ardanaz, Eva , et al. (2012) In British Journal of Nutrition 108(7). p.1307-1315

Abstract: Studies have suggested that moderate alcohol consumption is associated with a reduced risk of CVD and premature mortality in individuals with diabetes mellitus. However, history of alcohol consumption has hardly been taken into account. We investigated the association between current alcohol consumption and mortality in men and women with diabetes mellitus accounting for past alcohol consumption. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort was defined of 4797 participants with a confirmed diagnosis of diabetes mellitus. Men and women were assigned to categories of baseline and past alcohol consumption. Hazard ratios (HR) and 95% CI for total mortality were estimated with multivariable Cox... (More); Studies have suggested that moderate alcohol consumption is associated with a reduced risk of CVD and premature mortality in individuals with diabetes mellitus. However, history of alcohol consumption has hardly been taken into account. We investigated the association between current alcohol consumption and mortality in men and women with diabetes mellitus accounting for past alcohol consumption. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort was defined of 4797 participants with a confirmed diagnosis of diabetes mellitus. Men and women were assigned to categories of baseline and past alcohol consumption. Hazard ratios (HR) and 95% CI for total mortality were estimated with multivariable Cox regression models, using light alcohol consumption (>0-6 g/d) as the reference category. Compared with light alcohol consumption, no relationship was observed between consumption of 6 g/d or more and total mortality. HR for >6.12 g/d was 0.89(95% CI 0.61, 1.30) in men and 0.86(95% CI 0.46, 1.60) in women. Adjustment for past alcohol consumption did not change the estimates substantially. In individuals who at baseline reported abstaining from alcohol, mortality rates were increased relative to light consumers: HR was 1.52 (95% CI 0.99, 2.35) in men and 1.81 (95% CI 1.04, 3.17) in women. The present study in diabetic individuals showed no association between current alcohol consumption >6 g/d and mortality risk compared with light consumption. The increased mortality risk among non-consumers appeared to be affected by their past alcohol consumption rather than their current abstinence. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/3287525

author

Sluik, Diewertje ; Boeing, Heiner ; Bergmann, Manuela M. ; Schuetze, Madlen ; Teucher, Birgit ; Kaaks, Rudolf ; Tjonneland, Anne ; Overvad, Kim ; Arriola, Larraitz and Ardanaz, Eva , et al. (More)

Sluik, Diewertje ; Boeing, Heiner ; Bergmann, Manuela M. ; Schuetze, Madlen ; Teucher, Birgit ; Kaaks, Rudolf ; Tjonneland, Anne ; Overvad, Kim ; Arriola, Larraitz ; Ardanaz, Eva ; Bendinelli, Benedetta ; Agnoli, Claudia ; Tumino, Rosario ; Ricceri, Fulvio ; Mattiello, Amalia ; Spijkerman, Annemieke M. W. ; Beulens, Joline W. J. ; Grobbee, Diederick E. ; Nilsson, Peter ^LU ; Melander, Olle ^LU

; Franks, Paul ^LU ; Rolandsson, Olov ; Riboli, Elio ; Gallo, Valentina ; Romaguera, Dora and Noethlings, Ute (Less)

organization

publishing date

2012

type

Contribution to journal

publication status

published

subject

Nutrition and Dietetics

keywords

Diabetes mellitus, Alcohol consumption, History of alcohol consumption, Mortality

in

British Journal of Nutrition

volume

108

issue

7

pages

1307 - 1315

publisher

Cambridge University Press

external identifiers

wos:000309947600021
scopus:84869413246
pmid:22172339

ISSN

1475-2662

DOI

10.1017/S0007114511006532

language

English

LU publication?

yes

id

cdbf7265-bdd2-4544-9206-0186ef15282a (old id 3287525)

date added to LUP

2016-04-01 10:35:00

date last changed

2024-01-12 12:22:02

@article{cdbf7265-bdd2-4544-9206-0186ef15282a,
  abstract     = {{Studies have suggested that moderate alcohol consumption is associated with a reduced risk of CVD and premature mortality in individuals with diabetes mellitus. However, history of alcohol consumption has hardly been taken into account. We investigated the association between current alcohol consumption and mortality in men and women with diabetes mellitus accounting for past alcohol consumption. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort was defined of 4797 participants with a confirmed diagnosis of diabetes mellitus. Men and women were assigned to categories of baseline and past alcohol consumption. Hazard ratios (HR) and 95% CI for total mortality were estimated with multivariable Cox regression models, using light alcohol consumption (&gt;0-6 g/d) as the reference category. Compared with light alcohol consumption, no relationship was observed between consumption of 6 g/d or more and total mortality. HR for &gt;6.12 g/d was 0.89(95% CI 0.61, 1.30) in men and 0.86(95% CI 0.46, 1.60) in women. Adjustment for past alcohol consumption did not change the estimates substantially. In individuals who at baseline reported abstaining from alcohol, mortality rates were increased relative to light consumers: HR was 1.52 (95% CI 0.99, 2.35) in men and 1.81 (95% CI 1.04, 3.17) in women. The present study in diabetic individuals showed no association between current alcohol consumption &gt;6 g/d and mortality risk compared with light consumption. The increased mortality risk among non-consumers appeared to be affected by their past alcohol consumption rather than their current abstinence.}},
  author       = {{Sluik, Diewertje and Boeing, Heiner and Bergmann, Manuela M. and Schuetze, Madlen and Teucher, Birgit and Kaaks, Rudolf and Tjonneland, Anne and Overvad, Kim and Arriola, Larraitz and Ardanaz, Eva and Bendinelli, Benedetta and Agnoli, Claudia and Tumino, Rosario and Ricceri, Fulvio and Mattiello, Amalia and Spijkerman, Annemieke M. W. and Beulens, Joline W. J. and Grobbee, Diederick E. and Nilsson, Peter and Melander, Olle and Franks, Paul and Rolandsson, Olov and Riboli, Elio and Gallo, Valentina and Romaguera, Dora and Noethlings, Ute}},
  issn         = {{1475-2662}},
  keywords     = {{Diabetes mellitus; Alcohol consumption; History of alcohol consumption; Mortality}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1307--1315}},
  publisher    = {{Cambridge University Press}},
  series       = {{British Journal of Nutrition}},
  title        = {{Alcohol consumption and mortality in individuals with diabetes mellitus}},
  url          = {{https://lup.lub.lu.se/search/files/1964164/3563551.pdf}},
  doi          = {{10.1017/S0007114511006532}},
  volume       = {{108}},
  year         = {{2012}},
}

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Alcohol consumption and mortality in individuals with diabetes mellitus