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Impact of sex on perinatal mortality and morbidity in twins

Elsmén, Emma LU ; Källén, Karin LU ; Marsal, Karel LU ; Norman, Mikael and Hellstrom-Westas, Lena (2014) In Journal of Perinatal Medicine 42(2). p.225-231
Abstract
Objective: Twin studies offer opportunities to investigate mechanisms underlying sex-associated differences in perinatal outcomes. The objective of the study was to investigate sex-related differences in perinatal complications. Study design: A cohort of 16,045 twin pregnancies 32,090 twins - was explored for obstetric complications, perinatal and infant mortality, and neonatal morbidities. Results: Twin pregnancies with a female fetus had an increased risk for preeclampsia, but otherwise there were no pregnancy complications associated with fetal sex. After birth, female-female twins had lower early neonatal and infant mortality, and lower risk for respiratory morbidities than male-male twins at all gestational ages. In unlike-sexed twin... (More)
Objective: Twin studies offer opportunities to investigate mechanisms underlying sex-associated differences in perinatal outcomes. The objective of the study was to investigate sex-related differences in perinatal complications. Study design: A cohort of 16,045 twin pregnancies 32,090 twins - was explored for obstetric complications, perinatal and infant mortality, and neonatal morbidities. Results: Twin pregnancies with a female fetus had an increased risk for preeclampsia, but otherwise there were no pregnancy complications associated with fetal sex. After birth, female-female twins had lower early neonatal and infant mortality, and lower risk for respiratory morbidities than male-male twins at all gestational ages. In unlike-sexed twin pairs, very preterm males had higher respiratory morbidity than females and, females were at higher risk for being growth restricted. Conclusion: Male-male twins have higher respiratory morbidity and neonatal mortality than female-female twins. In unliked-sexed twin pairs, the males seem to be protected by having a female co-twin. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Growth restriction, newborn, respiratory morbidity, preeclampsia, preterm
in
Journal of Perinatal Medicine
volume
42
issue
2
pages
225 - 231
publisher
De Gruyter
external identifiers
  • wos:000332843500011
  • scopus:84898654897
  • pmid:24222256
ISSN
1619-3997
DOI
10.1515/jpm-2013-0147
language
English
LU publication?
yes
id
39712943-5ea7-455d-9d57-9bc57dc6f761 (old id 4411082)
date added to LUP
2016-04-01 11:04:59
date last changed
2022-01-26 05:10:55
@article{39712943-5ea7-455d-9d57-9bc57dc6f761,
  abstract     = {{Objective: Twin studies offer opportunities to investigate mechanisms underlying sex-associated differences in perinatal outcomes. The objective of the study was to investigate sex-related differences in perinatal complications. Study design: A cohort of 16,045 twin pregnancies 32,090 twins - was explored for obstetric complications, perinatal and infant mortality, and neonatal morbidities. Results: Twin pregnancies with a female fetus had an increased risk for preeclampsia, but otherwise there were no pregnancy complications associated with fetal sex. After birth, female-female twins had lower early neonatal and infant mortality, and lower risk for respiratory morbidities than male-male twins at all gestational ages. In unlike-sexed twin pairs, very preterm males had higher respiratory morbidity than females and, females were at higher risk for being growth restricted. Conclusion: Male-male twins have higher respiratory morbidity and neonatal mortality than female-female twins. In unliked-sexed twin pairs, the males seem to be protected by having a female co-twin.}},
  author       = {{Elsmén, Emma and Källén, Karin and Marsal, Karel and Norman, Mikael and Hellstrom-Westas, Lena}},
  issn         = {{1619-3997}},
  keywords     = {{Growth restriction; newborn; respiratory morbidity; preeclampsia; preterm}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{225--231}},
  publisher    = {{De Gruyter}},
  series       = {{Journal of Perinatal Medicine}},
  title        = {{Impact of sex on perinatal mortality and morbidity in twins}},
  url          = {{https://lup.lub.lu.se/search/files/2368024/4759202.pdf}},
  doi          = {{10.1515/jpm-2013-0147}},
  volume       = {{42}},
  year         = {{2014}},
}