Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.
(2015) In Cellular and Molecular Life Sciences 72(13). p.2535-2544- Abstract
- SRC-like adaptor protein (SLAP) is an adaptor protein structurally similar to the SRC family protein kinases. Like SRC, SLAP contains an SH3 domain followed by an SH2 domain but the kinase domain has been replaced by a unique C-terminal region. SLAP is expressed in a variety of cell types. Current studies suggest that it regulates signaling of various cell surface receptors including the B cell receptor, the T cell receptor, cytokine receptors and receptor tyrosine kinases which are important regulator of immune and cancer cell signaling. SLAP targets receptors, or its associated components, by recruiting the ubiquitin machinery and thereby destabilizing signaling. SLAP directs receptors to ubiquitination-mediated degradation and controls... (More)
- SRC-like adaptor protein (SLAP) is an adaptor protein structurally similar to the SRC family protein kinases. Like SRC, SLAP contains an SH3 domain followed by an SH2 domain but the kinase domain has been replaced by a unique C-terminal region. SLAP is expressed in a variety of cell types. Current studies suggest that it regulates signaling of various cell surface receptors including the B cell receptor, the T cell receptor, cytokine receptors and receptor tyrosine kinases which are important regulator of immune and cancer cell signaling. SLAP targets receptors, or its associated components, by recruiting the ubiquitin machinery and thereby destabilizing signaling. SLAP directs receptors to ubiquitination-mediated degradation and controls receptors turnover as well as signaling. Thus, SLAP appears to be an important component in regulating signal transduction required for immune and malignant cells. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5258642
- author
- Kazi, Julhash U. LU ; Kabir, Nuzhat N and Rönnstrand, Lars LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cellular and Molecular Life Sciences
- volume
- 72
- issue
- 13
- pages
- 2535 - 2544
- publisher
- Birkhäuser
- external identifiers
-
- pmid:25772501
- wos:000355751300005
- scopus:84930537998
- pmid:25772501
- ISSN
- 1420-9071
- DOI
- 10.1007/s00018-015-1882-6
- language
- English
- LU publication?
- yes
- id
- 7fb7d10d-4758-457a-802b-5d5a057bdd1e (old id 5258642)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25772501?dopt=Abstract
- date added to LUP
- 2016-04-01 11:15:25
- date last changed
- 2024-04-08 04:23:12
@article{7fb7d10d-4758-457a-802b-5d5a057bdd1e, abstract = {{SRC-like adaptor protein (SLAP) is an adaptor protein structurally similar to the SRC family protein kinases. Like SRC, SLAP contains an SH3 domain followed by an SH2 domain but the kinase domain has been replaced by a unique C-terminal region. SLAP is expressed in a variety of cell types. Current studies suggest that it regulates signaling of various cell surface receptors including the B cell receptor, the T cell receptor, cytokine receptors and receptor tyrosine kinases which are important regulator of immune and cancer cell signaling. SLAP targets receptors, or its associated components, by recruiting the ubiquitin machinery and thereby destabilizing signaling. SLAP directs receptors to ubiquitination-mediated degradation and controls receptors turnover as well as signaling. Thus, SLAP appears to be an important component in regulating signal transduction required for immune and malignant cells.}}, author = {{Kazi, Julhash U. and Kabir, Nuzhat N and Rönnstrand, Lars}}, issn = {{1420-9071}}, language = {{eng}}, number = {{13}}, pages = {{2535--2544}}, publisher = {{Birkhäuser}}, series = {{Cellular and Molecular Life Sciences}}, title = {{Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.}}, url = {{http://dx.doi.org/10.1007/s00018-015-1882-6}}, doi = {{10.1007/s00018-015-1882-6}}, volume = {{72}}, year = {{2015}}, }