Effect of two kinds of pectin and guar gum on 1,2-dimethylhydrazine initiation of colon tumors and on fecal beta-glucuronidase activity in the rat
(1981) In Cancer Research 41(6). p.23-2518- Abstract
The effect of 5% low-methoxylated pectin, high-methoxylated pectin, and guar gum on 1,2-dimethylhydrazine initiation of colon cancer was investigated using groups of 30 rats. The growth of the rats in the different groups was very similar to that of control group fed a fiber-free diet. Both kinds of pectin increased the multiplicity of color tumors, whereas guar gum did not significantly influence carcinogenesis. Bacterial beta-glucuronidase activity in feces and colonic content was the same in pectin-fed rats and controls but significantly lower in the guar gum group. Thus, it was not related to the number of tumors in each group.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/afe92857-c4cc-447e-8508-42a4a0c50278
- author
- Bauer, H G ; Asp, N G LU ; Dahlqvist, A ; Fredlund, P E ; Nyman, M LU and Oste, R
- organization
- publishing date
- 1981-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adenocarcinoma/chemically induced, Animals, Bacteria/enzymology, Body Weight, Cellulose/pharmacology, Colonic Neoplasms/chemically induced, Dietary Fiber/pharmacology, Dimethylhydrazines/toxicity, Feces/analysis, Glucuronidase/metabolism, Male, Methylhydrazines/toxicity, Pectins/pharmacology, Rats
- in
- Cancer Research
- volume
- 41
- issue
- 6
- pages
- 6 pages
- publisher
- American Association for Cancer Research Inc.
- external identifiers
-
- scopus:0019427281
- pmid:6263466
- ISSN
- 0008-5472
- language
- English
- LU publication?
- yes
- id
- afe92857-c4cc-447e-8508-42a4a0c50278
- alternative location
- http://cancerres.aacrjournals.org/content/canres/41/6/2518.full.pdf
- date added to LUP
- 2018-10-16 18:22:31
- date last changed
- 2024-01-15 04:13:52
@article{afe92857-c4cc-447e-8508-42a4a0c50278, abstract = {{<p>The effect of 5% low-methoxylated pectin, high-methoxylated pectin, and guar gum on 1,2-dimethylhydrazine initiation of colon cancer was investigated using groups of 30 rats. The growth of the rats in the different groups was very similar to that of control group fed a fiber-free diet. Both kinds of pectin increased the multiplicity of color tumors, whereas guar gum did not significantly influence carcinogenesis. Bacterial beta-glucuronidase activity in feces and colonic content was the same in pectin-fed rats and controls but significantly lower in the guar gum group. Thus, it was not related to the number of tumors in each group.</p>}}, author = {{Bauer, H G and Asp, N G and Dahlqvist, A and Fredlund, P E and Nyman, M and Oste, R}}, issn = {{0008-5472}}, keywords = {{Adenocarcinoma/chemically induced; Animals; Bacteria/enzymology; Body Weight; Cellulose/pharmacology; Colonic Neoplasms/chemically induced; Dietary Fiber/pharmacology; Dimethylhydrazines/toxicity; Feces/analysis; Glucuronidase/metabolism; Male; Methylhydrazines/toxicity; Pectins/pharmacology; Rats}}, language = {{eng}}, number = {{6}}, pages = {{23--2518}}, publisher = {{American Association for Cancer Research Inc.}}, series = {{Cancer Research}}, title = {{Effect of two kinds of pectin and guar gum on 1,2-dimethylhydrazine initiation of colon tumors and on fecal beta-glucuronidase activity in the rat}}, url = {{http://cancerres.aacrjournals.org/content/canres/41/6/2518.full.pdf}}, volume = {{41}}, year = {{1981}}, }