Increased Vitamin D intake differentiated according to skin color is needed to meet requirements in young Swedish children during winter : A double-blind randomized clinical trial
(2017) In American Journal of Clinical Nutrition 106(1). p.105-112- Abstract
Background: Dark skin and low exposure to sunlight increase the risk of Vitamin D insufficiency in children. Objective: The aim of the study was to evaluate the amount of Vitamin D needed to ascertain that most children > 4 y of age attain sufficient serum25-hydroxyVitamin D [S-25(OH)D; i.e.,≥50 nmol/L] during winter regardless of latitude and skin color. Design: In a longitudinal, double-blind, randomized, food-based intervention study, 5- to 7-y-old children from northern (638N) and southern (55°N) Sweden with fair (n = 108) and dark (n = 98) skin were included. Children, stratified by skin color by using Fitzpatrick's definition, were randomly assigned to receive milk-based Vitamin D3 supplements that provided 2... (More)
Background: Dark skin and low exposure to sunlight increase the risk of Vitamin D insufficiency in children. Objective: The aim of the study was to evaluate the amount of Vitamin D needed to ascertain that most children > 4 y of age attain sufficient serum25-hydroxyVitamin D [S-25(OH)D; i.e.,≥50 nmol/L] during winter regardless of latitude and skin color. Design: In a longitudinal, double-blind, randomized, food-based intervention study, 5- to 7-y-old children from northern (638N) and southern (55°N) Sweden with fair (n = 108) and dark (n = 98) skin were included. Children, stratified by skin color by using Fitzpatrick's definition, were randomly assigned to receive milk-based Vitamin D3 supplements that provided 2 (placebo), 10, or 25 μg/d during 3 winter months. Results: Mean daily Vitamin D intake increased from 6 to 17 mg and 26 mg in the intervention groups supplemented with 10 and 25 mg, respectively. In the intention-to-treat analysis, 90.2% (95% CI: 81.1%, 99.3%) of fair-skinned children randomly assigned to supplementation of 10 mg/d attained sufficient concentrations, whereas 25 mg/d was needed in dark-skinned children to reach sufficiency in 95.1% (95% CI: 88.5%, 100%). In children adherent to the study product, 97% (95% CI: 91.3%, 100%) and 87.9% (95% CI: 76.8%, 99%) of fair- and dark-skinned children, respectively, achieved sufficient concentrations if supplemented with 10 μg/d. By using 95% prediction intervals for 30 and 50 nmol S-25(OH)D/L, intakes of 6 and 20 μg/d are required in fair-skinned children, whereas 14 and 28 μg/d are required in children with dark skin. Conclusion: Children with fair and dark skin require Vitamin D intakes of 20 and 28 μg/d, respectively, to maintain S-25(OH)D ≥50 nmol/L, whereas intakes of 6 and 14 mg/d, respectively, are required to maintain concentrations ≥30 nmol/L during winter. This trial was registered at clinicaltrials.gov as NCT01741324.
(Less)
- author
- Öhlund, Inger ; Lind, Torbjörn ; Hernell, Olle ; Silfverdal, Sven Arne and Äkeson, Pia Karlsland LU
- organization
- publishing date
- 2017-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Child, Intervention, Latitude, Season, Serum 25-hydroxyVitamin D, Vitamin D
- in
- American Journal of Clinical Nutrition
- volume
- 106
- issue
- 1
- pages
- 8 pages
- publisher
- Oxford University Press
- external identifiers
-
- pmid:28615261
- wos:000404593900015
- scopus:85021796095
- ISSN
- 0002-9165
- DOI
- 10.3945/ajcn.116.147108
- language
- English
- LU publication?
- yes
- id
- f6b7516c-df92-4f50-b24e-0c4d588cfde1
- date added to LUP
- 2017-07-25 14:25:09
- date last changed
- 2024-03-31 13:28:33
@article{f6b7516c-df92-4f50-b24e-0c4d588cfde1, abstract = {{<p>Background: Dark skin and low exposure to sunlight increase the risk of Vitamin D insufficiency in children. Objective: The aim of the study was to evaluate the amount of Vitamin D needed to ascertain that most children > 4 y of age attain sufficient serum25-hydroxyVitamin D [S-25(OH)D; i.e.,≥50 nmol/L] during winter regardless of latitude and skin color. Design: In a longitudinal, double-blind, randomized, food-based intervention study, 5- to 7-y-old children from northern (638N) and southern (55°N) Sweden with fair (n = 108) and dark (n = 98) skin were included. Children, stratified by skin color by using Fitzpatrick's definition, were randomly assigned to receive milk-based Vitamin D<sub>3</sub> supplements that provided 2 (placebo), 10, or 25 μg/d during 3 winter months. Results: Mean daily Vitamin D intake increased from 6 to 17 mg and 26 mg in the intervention groups supplemented with 10 and 25 mg, respectively. In the intention-to-treat analysis, 90.2% (95% CI: 81.1%, 99.3%) of fair-skinned children randomly assigned to supplementation of 10 mg/d attained sufficient concentrations, whereas 25 mg/d was needed in dark-skinned children to reach sufficiency in 95.1% (95% CI: 88.5%, 100%). In children adherent to the study product, 97% (95% CI: 91.3%, 100%) and 87.9% (95% CI: 76.8%, 99%) of fair- and dark-skinned children, respectively, achieved sufficient concentrations if supplemented with 10 μg/d. By using 95% prediction intervals for 30 and 50 nmol S-25(OH)D/L, intakes of 6 and 20 μg/d are required in fair-skinned children, whereas 14 and 28 μg/d are required in children with dark skin. Conclusion: Children with fair and dark skin require Vitamin D intakes of 20 and 28 μg/d, respectively, to maintain S-25(OH)D ≥50 nmol/L, whereas intakes of 6 and 14 mg/d, respectively, are required to maintain concentrations ≥30 nmol/L during winter. This trial was registered at clinicaltrials.gov as NCT01741324.</p>}}, author = {{Öhlund, Inger and Lind, Torbjörn and Hernell, Olle and Silfverdal, Sven Arne and Äkeson, Pia Karlsland}}, issn = {{0002-9165}}, keywords = {{Child; Intervention; Latitude; Season; Serum 25-hydroxyVitamin D; Vitamin D}}, language = {{eng}}, month = {{07}}, number = {{1}}, pages = {{105--112}}, publisher = {{Oxford University Press}}, series = {{American Journal of Clinical Nutrition}}, title = {{Increased Vitamin D intake differentiated according to skin color is needed to meet requirements in young Swedish children during winter : A double-blind randomized clinical trial}}, url = {{http://dx.doi.org/10.3945/ajcn.116.147108}}, doi = {{10.3945/ajcn.116.147108}}, volume = {{106}}, year = {{2017}}, }