BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma article
(2018) In Cell Death and Disease 9(5).- Abstract
BRCA1-associated protein 1 (BAP1) is a nuclear deubiquitinating enzyme that is associated with multiprotein complexes that regulate key cellular pathways, including cell cycle, cellular differentiation, cell death, and the DNA damage response. In this study, we found that the reduced expression of BAP1 pro6motes the survival of neuroblastoma cells, and restoring the levels of BAP1 in these cells facilitated a delay in S and G2/M phase of the cell cycle, as well as cell apoptosis. The mechanism that BAP1 induces cell death is mediated via an interaction with 14-3-3 protein. The association between BAP1 and 14-3-3 protein releases the apoptotic inducer protein Bax from 14-3-3 and promotes cell death through the intrinsic apoptosis... (More)
BRCA1-associated protein 1 (BAP1) is a nuclear deubiquitinating enzyme that is associated with multiprotein complexes that regulate key cellular pathways, including cell cycle, cellular differentiation, cell death, and the DNA damage response. In this study, we found that the reduced expression of BAP1 pro6motes the survival of neuroblastoma cells, and restoring the levels of BAP1 in these cells facilitated a delay in S and G2/M phase of the cell cycle, as well as cell apoptosis. The mechanism that BAP1 induces cell death is mediated via an interaction with 14-3-3 protein. The association between BAP1 and 14-3-3 protein releases the apoptotic inducer protein Bax from 14-3-3 and promotes cell death through the intrinsic apoptosis pathway. Xenograft studies confirmed that the expression of BAP1 reduces tumor growth and progression in vivo by lowering the levels of pro-survival factors such as Bcl-2, which in turn diminish the survival potential of the tumor cells. Patient data analyses confirmed the finding that the high-BAP1 mRNA expression correlates with a better clinical outcome. In summary, our study uncovers a new mechanism for BAP1 in the regulation of cell apoptosis in neuroblastoma cells.
(Less)
- author
- organization
- publishing date
- 2018-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cell Death and Disease
- volume
- 9
- issue
- 5
- article number
- 458
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:29686263
- scopus:85045947649
- ISSN
- 2041-4889
- DOI
- 10.1038/s41419-018-0500-6
- language
- English
- LU publication?
- yes
- id
- f75ca2cc-04b3-4685-a2cc-bffd761af957
- date added to LUP
- 2018-05-07 13:01:17
- date last changed
- 2024-09-16 21:24:25
@article{f75ca2cc-04b3-4685-a2cc-bffd761af957, abstract = {{<p>BRCA1-associated protein 1 (BAP1) is a nuclear deubiquitinating enzyme that is associated with multiprotein complexes that regulate key cellular pathways, including cell cycle, cellular differentiation, cell death, and the DNA damage response. In this study, we found that the reduced expression of BAP1 pro6motes the survival of neuroblastoma cells, and restoring the levels of BAP1 in these cells facilitated a delay in S and G2/M phase of the cell cycle, as well as cell apoptosis. The mechanism that BAP1 induces cell death is mediated via an interaction with 14-3-3 protein. The association between BAP1 and 14-3-3 protein releases the apoptotic inducer protein Bax from 14-3-3 and promotes cell death through the intrinsic apoptosis pathway. Xenograft studies confirmed that the expression of BAP1 reduces tumor growth and progression in vivo by lowering the levels of pro-survival factors such as Bcl-2, which in turn diminish the survival potential of the tumor cells. Patient data analyses confirmed the finding that the high-BAP1 mRNA expression correlates with a better clinical outcome. In summary, our study uncovers a new mechanism for BAP1 in the regulation of cell apoptosis in neuroblastoma cells.</p>}}, author = {{Sime, Wondossen and Niu, Qiankun and Abassi, Yasmin and Masoumi, Katarzyna Chmielarska and Zarrizi, Reihaneh and Køhler, Julie Bonne and Kjellström, Sven and Lasorsa, Vito Alessandro and Capasso, Mario and Fu, Haian and Massoumi, Ramin}}, issn = {{2041-4889}}, language = {{eng}}, month = {{01}}, number = {{5}}, publisher = {{Nature Publishing Group}}, series = {{Cell Death and Disease}}, title = {{BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma article}}, url = {{http://dx.doi.org/10.1038/s41419-018-0500-6}}, doi = {{10.1038/s41419-018-0500-6}}, volume = {{9}}, year = {{2018}}, }