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Associations between food patterns defined by cluster analysis and colorectal cancer incidence in the NIH-AARP diet and health study.

Wirfält, Elisabet LU ; Midthune, D; Reedy, J; Mitrou, P; Flood, A; Subar, A F; Leitzmann, M; Mouw, T; Hollenbeck, A R and Schatzkin, A, et al. (2009) In European Journal of Clinical Nutrition 63. p.707-717
Abstract
Background/Objectives:To examine associations between food patterns, constructed with cluster analysis, and colorectal cancer incidence within the National Institutes of Health-AARP Diet and Health Study.Subjects/Methods:A prospective cohort, aged 50-71 years at baseline in 1995-1996, followed until the end of 2000. Food patterns were constructed, separately in men (n=293 576) and women (n=198 730), with 181 food variables (daily intake frequency per 1000 kcal) from a food frequency questionnaire. Four large clusters were identified in men and three in women. Cox proportional hazards regression examined associations between patterns and cancer incidence.Results:In men, a vegetable and fruit pattern was associated with reduced colorectal... (More)
Background/Objectives:To examine associations between food patterns, constructed with cluster analysis, and colorectal cancer incidence within the National Institutes of Health-AARP Diet and Health Study.Subjects/Methods:A prospective cohort, aged 50-71 years at baseline in 1995-1996, followed until the end of 2000. Food patterns were constructed, separately in men (n=293 576) and women (n=198 730), with 181 food variables (daily intake frequency per 1000 kcal) from a food frequency questionnaire. Four large clusters were identified in men and three in women. Cox proportional hazards regression examined associations between patterns and cancer incidence.Results:In men, a vegetable and fruit pattern was associated with reduced colorectal cancer incidence (multivariate hazard ratio, HR: 0.85; 95% confidence interval, CI: 0.76, 0.94), when compared to less salutary food choices. Both the vegetable and fruit pattern and a fat-reduced foods pattern were associated with reduced rectal cancer incidence in men. In women, a similar vegetable and fruit pattern was associated with colorectal cancer protection (age-adjusted HR: 0.82; 95% CI: 0.70, 0.95), but the association was not statistically significant in multivariate analysis.Conclusions:These results, together with findings from previous studies support the hypothesis that micronutrient dense, low-fat, high-fiber food patterns protect against colorectal cancer.European Journal of Clinical Nutrition advance online publication, 6 August 2008; doi:10.1038/ejcn.2008.40. (Less)
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European Journal of Clinical Nutrition
volume
63
pages
707 - 717
publisher
Nature Publishing Group
external identifiers
  • WOS:000266572000001
  • PMID:18685556
  • Scopus:67549121649
ISSN
1476-5640
DOI
10.1038/ejcn.2008.40
language
English
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yes
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2cfd6e6e-d6fa-497c-95fb-01eb38cea92d (old id 1223409)
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http://www.ncbi.nlm.nih.gov/pubmed/18685556?dopt=Abstract
date added to LUP
2008-09-11 16:03:10
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2016-10-13 04:26:28
@misc{2cfd6e6e-d6fa-497c-95fb-01eb38cea92d,
  abstract     = {Background/Objectives:To examine associations between food patterns, constructed with cluster analysis, and colorectal cancer incidence within the National Institutes of Health-AARP Diet and Health Study.Subjects/Methods:A prospective cohort, aged 50-71 years at baseline in 1995-1996, followed until the end of 2000. Food patterns were constructed, separately in men (n=293 576) and women (n=198 730), with 181 food variables (daily intake frequency per 1000 kcal) from a food frequency questionnaire. Four large clusters were identified in men and three in women. Cox proportional hazards regression examined associations between patterns and cancer incidence.Results:In men, a vegetable and fruit pattern was associated with reduced colorectal cancer incidence (multivariate hazard ratio, HR: 0.85; 95% confidence interval, CI: 0.76, 0.94), when compared to less salutary food choices. Both the vegetable and fruit pattern and a fat-reduced foods pattern were associated with reduced rectal cancer incidence in men. In women, a similar vegetable and fruit pattern was associated with colorectal cancer protection (age-adjusted HR: 0.82; 95% CI: 0.70, 0.95), but the association was not statistically significant in multivariate analysis.Conclusions:These results, together with findings from previous studies support the hypothesis that micronutrient dense, low-fat, high-fiber food patterns protect against colorectal cancer.European Journal of Clinical Nutrition advance online publication, 6 August 2008; doi:10.1038/ejcn.2008.40.},
  author       = {Wirfält, Elisabet and Midthune, D and Reedy, J and Mitrou, P and Flood, A and Subar, A F and Leitzmann, M and Mouw, T and Hollenbeck, A R and Schatzkin, A and Kipnis, V},
  issn         = {1476-5640},
  language     = {eng},
  pages        = {707--717},
  publisher    = {ARRAY(0x9a7bb70)},
  series       = {European Journal of Clinical Nutrition},
  title        = {Associations between food patterns defined by cluster analysis and colorectal cancer incidence in the NIH-AARP diet and health study.},
  url          = {http://dx.doi.org/10.1038/ejcn.2008.40},
  volume       = {63},
  year         = {2009},
}