Advanced

Thylakoids promote release of the satiety hormone cholecystokinin while reducing insulin in healthy humans.

Köhnke, Rickard LU ; Lindbo, Agnes; Larsson, Therese; Lindqvist, Andreas LU ; Rayner, Marilyn LU ; Emek, Sinan Cem LU ; Albertsson, Per-Åke LU ; Rehfeld, Jens; Landin-Olsson, Mona LU and Erlanson-Albertsson, Charlotte LU (2009) In Scandinavian Journal of Gastroenterology 44(6). p.712-719
Abstract
Objective. The effects of a promising new appetite suppressor named "thylakoids" (membrane proteins derived from spinach leaves) were examined in a single meal in man. Thylakoids inhibit the lipase/colipase hydrolysis of triacylglycerols in vitro and suppress food intake, decrease body-weight gain and raise the satiety hormone cholecystokinin (CCK) in rats, but their effects in man remain unclear. The aim of this study was to investigate whether thylakoids, when added to a test meal, affect appetite regulation and blood parameters in healthy individuals. Material and methods. In an intervention crossover study, healthy individuals of normal weight (n=11) were offered a high-fat meal with and without the addition of thylakoids. Blood... (More)
Objective. The effects of a promising new appetite suppressor named "thylakoids" (membrane proteins derived from spinach leaves) were examined in a single meal in man. Thylakoids inhibit the lipase/colipase hydrolysis of triacylglycerols in vitro and suppress food intake, decrease body-weight gain and raise the satiety hormone cholecystokinin (CCK) in rats, but their effects in man remain unclear. The aim of this study was to investigate whether thylakoids, when added to a test meal, affect appetite regulation and blood parameters in healthy individuals. Material and methods. In an intervention crossover study, healthy individuals of normal weight (n=11) were offered a high-fat meal with and without the addition of thylakoids. Blood samples were taken 0 (prior to meal), 30, 60, 120, 180, 240, 300 and 360 min after the start of the meal. Blood samples were analysed for satiety and hunger hormones (CCK, leptin and ghrelin), insulin and blood metabolites (glucose and free fatty acids). Results. The CCK level increased, in particular between the 120 min time-point and onwards, the ghrelin level was reduced at 120 min and leptin level increased at 360 min after intake of the thylakoid-enriched meal. The insulin level was reduced, whereas glucose concentrations were unchanged. Free fatty acids were reduced between time-point 120 min and onwards after the thylakoid meal. Conclusions. The addition of thylakoids to energy-dense food promotes satiety signals and reduces insulin response during a single meal in man. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cholecystokinin, Eating, Female, Humans, Insulin, Male, Satiety Response, Thylakoids
in
Scandinavian Journal of Gastroenterology
volume
44
issue
6
pages
712 - 719
publisher
Taylor & Francis
external identifiers
  • WOS:000266199200010
  • PMID:19308799
  • Scopus:67651151597
ISSN
1502-7708
DOI
10.1080/00365520902803499
language
English
LU publication?
yes
id
d314a2e9-4c55-406b-bd40-e04daef48263 (old id 1367504)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19308799?dopt=Abstract
date added to LUP
2009-04-06 13:41:51
date last changed
2016-10-30 04:35:37
@misc{d314a2e9-4c55-406b-bd40-e04daef48263,
  abstract     = {Objective. The effects of a promising new appetite suppressor named "thylakoids" (membrane proteins derived from spinach leaves) were examined in a single meal in man. Thylakoids inhibit the lipase/colipase hydrolysis of triacylglycerols in vitro and suppress food intake, decrease body-weight gain and raise the satiety hormone cholecystokinin (CCK) in rats, but their effects in man remain unclear. The aim of this study was to investigate whether thylakoids, when added to a test meal, affect appetite regulation and blood parameters in healthy individuals. Material and methods. In an intervention crossover study, healthy individuals of normal weight (n=11) were offered a high-fat meal with and without the addition of thylakoids. Blood samples were taken 0 (prior to meal), 30, 60, 120, 180, 240, 300 and 360 min after the start of the meal. Blood samples were analysed for satiety and hunger hormones (CCK, leptin and ghrelin), insulin and blood metabolites (glucose and free fatty acids). Results. The CCK level increased, in particular between the 120 min time-point and onwards, the ghrelin level was reduced at 120 min and leptin level increased at 360 min after intake of the thylakoid-enriched meal. The insulin level was reduced, whereas glucose concentrations were unchanged. Free fatty acids were reduced between time-point 120 min and onwards after the thylakoid meal. Conclusions. The addition of thylakoids to energy-dense food promotes satiety signals and reduces insulin response during a single meal in man.},
  author       = {Köhnke, Rickard and Lindbo, Agnes and Larsson, Therese and Lindqvist, Andreas and Rayner, Marilyn and Emek, Sinan Cem and Albertsson, Per-Åke and Rehfeld, Jens and Landin-Olsson, Mona and Erlanson-Albertsson, Charlotte},
  issn         = {1502-7708},
  keyword      = {Cholecystokinin,Eating,Female,Humans,Insulin,Male,Satiety Response,Thylakoids},
  language     = {eng},
  number       = {6},
  pages        = {712--719},
  publisher    = {ARRAY(0x5f507e8)},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Thylakoids promote release of the satiety hormone cholecystokinin while reducing insulin in healthy humans.},
  url          = {http://dx.doi.org/10.1080/00365520902803499},
  volume       = {44},
  year         = {2009},
}