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Plasma variation and reproducibility of oxidized LDL-cholesterol and low-grade inflammation biomarkers among participants of the Malmö Diet and Cancer cohort

Alves Dias, Joana LU ; Hellstrand, Sophie LU ; Ericson, Ulrika LU ; Gullberg, B. LU ; Nilsson, Jan LU ; Alm, Ragnar LU ; Persson, Margaretha LU ; Engström, Gunnar LU ; Nordin Fredrikson, Gunilla LU and Hedblad, B. LU , et al. (2016) In Biomarkers 21(6). p.562-571
Abstract

Context: Large epidemiological studies often collect non-fasting samples, although the reliability of biomarkers may be uncertain. Objective: To explore the reliability and reproducibility of a single measurement of selected biomarkers in a sub-sample of the Malmö Diet and Cancer cohort. Methods: We estimated single- and average-measures intraclass correlation coefficients (ICC) for oxidized (ox)-LDL, interleukin (IL)-1β, IL-6, IL-8 and TNF-α. Results: Single-measures ICC in non-fasting samples of ox-LDL, IL-1β, IL-6, IL-8 and TNF-α were the following: 0.85, 0.71, 0.61, 0.78 and 0.66 for men, and 0.67, 0.81, 0.87, 0.69 and 0.81 for women. Biomarkers at non-fasting and fasting samples were highly correlated (all r > 0.80).... (More)

Context: Large epidemiological studies often collect non-fasting samples, although the reliability of biomarkers may be uncertain. Objective: To explore the reliability and reproducibility of a single measurement of selected biomarkers in a sub-sample of the Malmö Diet and Cancer cohort. Methods: We estimated single- and average-measures intraclass correlation coefficients (ICC) for oxidized (ox)-LDL, interleukin (IL)-1β, IL-6, IL-8 and TNF-α. Results: Single-measures ICC in non-fasting samples of ox-LDL, IL-1β, IL-6, IL-8 and TNF-α were the following: 0.85, 0.71, 0.61, 0.78 and 0.66 for men, and 0.67, 0.81, 0.87, 0.69 and 0.81 for women. Biomarkers at non-fasting and fasting samples were highly correlated (all r > 0.80). Conclusions: The observed ICC suggest that most of the examined biomarkers (non-fasting blood) would allow meaningful analysis in epidemiological studies.

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organization
publishing date
type
Contribution to journal
publication status
in press
subject
keywords
Biomarkers of inflammation, cytokines, epidemiology, ICC, variation
in
Biomarkers
volume
21
issue
6
pages
10 pages
publisher
Taylor & Francis
external identifiers
  • Scopus:84963579045
ISSN
1354-750X
DOI
10.3109/1354750X.2016.1160431
language
English
LU publication?
yes
id
c0551e3a-4881-47fe-85ee-1af156c9983c
date added to LUP
2016-05-18 13:48:49
date last changed
2016-10-13 05:08:53
@misc{c0551e3a-4881-47fe-85ee-1af156c9983c,
  abstract     = {<p>Context: Large epidemiological studies often collect non-fasting samples, although the reliability of biomarkers may be uncertain. Objective: To explore the reliability and reproducibility of a single measurement of selected biomarkers in a sub-sample of the Malmö Diet and Cancer cohort. Methods: We estimated single- and average-measures intraclass correlation coefficients (ICC) for oxidized (ox)-LDL, interleukin (IL)-1β, IL-6, IL-8 and TNF-α. Results: Single-measures ICC in non-fasting samples of ox-LDL, IL-1β, IL-6, IL-8 and TNF-α were the following: 0.85, 0.71, 0.61, 0.78 and 0.66 for men, and 0.67, 0.81, 0.87, 0.69 and 0.81 for women. Biomarkers at non-fasting and fasting samples were highly correlated (all r &gt; 0.80). Conclusions: The observed ICC suggest that most of the examined biomarkers (non-fasting blood) would allow meaningful analysis in epidemiological studies.</p>},
  author       = {Alves Dias, Joana and Hellstrand, Sophie and Ericson, Ulrika and Gullberg, B. and Nilsson, Jan and Alm, Ragnar and Persson, Margaretha and Engström, Gunnar and Nordin Fredrikson, Gunilla and Hedblad, B. and Wirfält, Elisabet},
  issn         = {1354-750X},
  keyword      = {Biomarkers of inflammation,cytokines,epidemiology,ICC,variation},
  language     = {eng},
  month        = {04},
  number       = {6},
  pages        = {562--571},
  publisher    = {ARRAY(0x95a2aa8)},
  series       = {Biomarkers},
  title        = {Plasma variation and reproducibility of oxidized LDL-cholesterol and low-grade inflammation biomarkers among participants of the Malmö Diet and Cancer cohort},
  url          = {http://dx.doi.org/10.3109/1354750X.2016.1160431},
  volume       = {21},
  year         = {2016},
}