Plasma variation and reproducibility of oxidized LDL-cholesterol and low-grade inflammation biomarkers among participants of the Malmö Diet and Cancer cohort
(2016) In Biomarkers 21(6). p.562-571- Abstract
Context: Large epidemiological studies often collect non-fasting samples, although the reliability of biomarkers may be uncertain. Objective: To explore the reliability and reproducibility of a single measurement of selected biomarkers in a sub-sample of the Malmö Diet and Cancer cohort. Methods: We estimated single- and average-measures intraclass correlation coefficients (ICC) for oxidized (ox)-LDL, interleukin (IL)-1β, IL-6, IL-8 and TNF-α. Results: Single-measures ICC in non-fasting samples of ox-LDL, IL-1β, IL-6, IL-8 and TNF-α were the following: 0.85, 0.71, 0.61, 0.78 and 0.66 for men, and 0.67, 0.81, 0.87, 0.69 and 0.81 for women. Biomarkers at non-fasting and fasting samples were highly correlated (all r > 0.80).... (More)
Context: Large epidemiological studies often collect non-fasting samples, although the reliability of biomarkers may be uncertain. Objective: To explore the reliability and reproducibility of a single measurement of selected biomarkers in a sub-sample of the Malmö Diet and Cancer cohort. Methods: We estimated single- and average-measures intraclass correlation coefficients (ICC) for oxidized (ox)-LDL, interleukin (IL)-1β, IL-6, IL-8 and TNF-α. Results: Single-measures ICC in non-fasting samples of ox-LDL, IL-1β, IL-6, IL-8 and TNF-α were the following: 0.85, 0.71, 0.61, 0.78 and 0.66 for men, and 0.67, 0.81, 0.87, 0.69 and 0.81 for women. Biomarkers at non-fasting and fasting samples were highly correlated (all r > 0.80). Conclusions: The observed ICC suggest that most of the examined biomarkers (non-fasting blood) would allow meaningful analysis in epidemiological studies.
(Less)
- author
- organization
-
- Nutrition Epidemiology (research group)
- Diabetes - Cardiovascular Disease (research group)
- Cardiovascular Research - Immunity and Atherosclerosis (research group)
- Internal Medicine - Epidemiology (research group)
- Cardiovascular Research - Epidemiology (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- publishing date
- 2016-08-17
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Biomarkers of inflammation, cytokines, epidemiology, ICC, variation
- in
- Biomarkers
- volume
- 21
- issue
- 6
- pages
- 562 - 571
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:84963579045
- pmid:27075407
- wos:000381508600011
- ISSN
- 1354-750X
- DOI
- 10.3109/1354750X.2016.1160431
- language
- English
- LU publication?
- yes
- id
- c0551e3a-4881-47fe-85ee-1af156c9983c
- date added to LUP
- 2016-05-18 13:48:49
- date last changed
- 2024-03-06 23:21:40
@article{c0551e3a-4881-47fe-85ee-1af156c9983c, abstract = {{<p>Context: Large epidemiological studies often collect non-fasting samples, although the reliability of biomarkers may be uncertain. Objective: To explore the reliability and reproducibility of a single measurement of selected biomarkers in a sub-sample of the Malmö Diet and Cancer cohort. Methods: We estimated single- and average-measures intraclass correlation coefficients (ICC) for oxidized (ox)-LDL, interleukin (IL)-1β, IL-6, IL-8 and TNF-α. Results: Single-measures ICC in non-fasting samples of ox-LDL, IL-1β, IL-6, IL-8 and TNF-α were the following: 0.85, 0.71, 0.61, 0.78 and 0.66 for men, and 0.67, 0.81, 0.87, 0.69 and 0.81 for women. Biomarkers at non-fasting and fasting samples were highly correlated (all r > 0.80). Conclusions: The observed ICC suggest that most of the examined biomarkers (non-fasting blood) would allow meaningful analysis in epidemiological studies.</p>}}, author = {{Alves Dias, Joana and Hellstrand, Sophie and Ericson, Ulrika and Gullberg, B. and Nilsson, Jan and Alm, Ragnar and Persson, Margaretha and Engström, Gunnar and Nordin Fredrikson, Gunilla and Hedblad, B. and Wirfält, Elisabet}}, issn = {{1354-750X}}, keywords = {{Biomarkers of inflammation; cytokines; epidemiology; ICC; variation}}, language = {{eng}}, month = {{08}}, number = {{6}}, pages = {{562--571}}, publisher = {{Taylor & Francis}}, series = {{Biomarkers}}, title = {{Plasma variation and reproducibility of oxidized LDL-cholesterol and low-grade inflammation biomarkers among participants of the Malmö Diet and Cancer cohort}}, url = {{http://dx.doi.org/10.3109/1354750X.2016.1160431}}, doi = {{10.3109/1354750X.2016.1160431}}, volume = {{21}}, year = {{2016}}, }