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Genetic predisposition to coffee consumption and the association with the early risk of atherosclerosis

Qiao, Xiangyu ; Toma, Vanessa William ; Wang, Jing ; Herraiz-Adillo, Ángel ; Söderholm, Simon ; Berglind, Daniel ; Calling, Susanna LU ; Daka, Bledar ; Martinell, Mats and Bergman, Frida , et al. (2026) In Scientific Reports 16(1).
Abstract

The cardiovascular effects of coffee consumption remain debated, particularly regarding early-stage subclinical atherosclerosis. This study investigated the association between coffee intake, genetic predisposition, and the risk of subclinical coronary and carotid atherosclerosis in 24,835 participants from the Swedish CArdioPulmonary bioImage Study (SCAPIS). Coffee intake was assessed via self-reported questionnaires. Atherosclerosis was assessed via segment involvement score (SIS), coronary artery calcium score (CACS) and carotid plaque. Observational analysis showed no significant association between coffee consumption and SIS, CACS, or carotid plaques. However, both one-sample and two-sample (SCAPIS and UK Biobank) Mendelian... (More)

The cardiovascular effects of coffee consumption remain debated, particularly regarding early-stage subclinical atherosclerosis. This study investigated the association between coffee intake, genetic predisposition, and the risk of subclinical coronary and carotid atherosclerosis in 24,835 participants from the Swedish CArdioPulmonary bioImage Study (SCAPIS). Coffee intake was assessed via self-reported questionnaires. Atherosclerosis was assessed via segment involvement score (SIS), coronary artery calcium score (CACS) and carotid plaque. Observational analysis showed no significant association between coffee consumption and SIS, CACS, or carotid plaques. However, both one-sample and two-sample (SCAPIS and UK Biobank) Mendelian randomization (MR) analyses showed an association between genetic predisposition to higher coffee consumption and increased SIS. Stratification analyses further explored differences in genetic associations across varying coffee consumption levels. Among individuals consuming coffee more than twice daily, two coffee consumption-associated single nucleotide polymorphisms (SNPs) in AHR and CYP1A1/CYP1A2 were correlated with SIS. Integrative metabolomics and proteomics analyses identified lipid-related metabolites (triglycerides, phospholipids, free cholesterol) and inflammation-related proteins (DLK1, IL1RL2, CCL17) associated with the genetic proxy of coffee consumption. These findings suggest that genetically influenced coffee consumption may be associated with coronary atherosclerosis risk in frequent coffee drinkers, although the underlying biological basis remains to be clarified.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Atherosclerosis, Coffee consumption, Mendelian randomization, Multi-omics
in
Scientific Reports
volume
16
issue
1
article number
9652
publisher
Nature Publishing Group
external identifiers
  • scopus:105034349244
  • pmid:41865070
ISSN
2045-2322
DOI
10.1038/s41598-026-44122-2
language
English
LU publication?
yes
additional info
Publisher Copyright: © The Author(s) 2026.
id
03021bf7-9a82-4431-bc11-3b9805c64b97
date added to LUP
2026-05-20 14:31:51
date last changed
2026-09-11 05:38:21
@article{03021bf7-9a82-4431-bc11-3b9805c64b97,
  abstract     = {{<p>The cardiovascular effects of coffee consumption remain debated, particularly regarding early-stage subclinical atherosclerosis. This study investigated the association between coffee intake, genetic predisposition, and the risk of subclinical coronary and carotid atherosclerosis in 24,835 participants from the Swedish CArdioPulmonary bioImage Study (SCAPIS). Coffee intake was assessed via self-reported questionnaires. Atherosclerosis was assessed via segment involvement score (SIS), coronary artery calcium score (CACS) and carotid plaque. Observational analysis showed no significant association between coffee consumption and SIS, CACS, or carotid plaques. However, both one-sample and two-sample (SCAPIS and UK Biobank) Mendelian randomization (MR) analyses showed an association between genetic predisposition to higher coffee consumption and increased SIS. Stratification analyses further explored differences in genetic associations across varying coffee consumption levels. Among individuals consuming coffee more than twice daily, two coffee consumption-associated single nucleotide polymorphisms (SNPs) in AHR and CYP1A1/CYP1A2 were correlated with SIS. Integrative metabolomics and proteomics analyses identified lipid-related metabolites (triglycerides, phospholipids, free cholesterol) and inflammation-related proteins (DLK1, IL1RL2, CCL17) associated with the genetic proxy of coffee consumption. These findings suggest that genetically influenced coffee consumption may be associated with coronary atherosclerosis risk in frequent coffee drinkers, although the underlying biological basis remains to be clarified.</p>}},
  author       = {{Qiao, Xiangyu and Toma, Vanessa William and Wang, Jing and Herraiz-Adillo, Ángel and Söderholm, Simon and Berglind, Daniel and Calling, Susanna and Daka, Bledar and Martinell, Mats and Bergman, Frida and Henriksson, Pontus and Ghafouri, Bijar and Ulander, Martin and Östgren, Carl Johan and Cantù, Claudio and Zhong, Wen and Iredahl, Fredrik}},
  issn         = {{2045-2322}},
  keywords     = {{Atherosclerosis; Coffee consumption; Mendelian randomization; Multi-omics}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Genetic predisposition to coffee consumption and the association with the early risk of atherosclerosis}},
  url          = {{http://dx.doi.org/10.1038/s41598-026-44122-2}},
  doi          = {{10.1038/s41598-026-44122-2}},
  volume       = {{16}},
  year         = {{2026}},
}