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Health-Related Quality of Life in Patients Undergoing Surgery for Primary Hyperparathyroidism : Patient Reported Outcome Measures

Trinh, Lily N. ; Okose, Okenwa C. ; Abdelhamid-Ahmed, Amr H. ; Saito, Yoshiyuki ; Russell, Marika D. ; Athni, Tejas S. ; Karcioglu, Amanda Silver ; Cheung, Anthony Y. ; Srikanthan, Adithya and Alcaro, Christina , et al. (2025) In Head and Neck
Abstract

Background: Parathyroidectomy is typically curative for primary hyperparathyroidism (PHPT) and may lead to health-related quality of life (HRQL) improvements. We aim to evaluate general and disease-specific HRQL changes in patients undergoing surgery for PHPT from their perspective. Methods: Patients completed three patient-reported outcome measure (PROM) surveys before and after surgery: (1) Worry survey; (2) Voice Handicap Index-10 (VHI-10); and (3) Patient-Reported Outcome Measurement Information System Global-10 (PROMIS). Results: Forty-four patients were included with a median age of 65 years, with 39 females (89%) included. Thirty-two patients (73%) had a single adenoma, and 12 (27%) had multigland disease (parathyroid... (More)

Background: Parathyroidectomy is typically curative for primary hyperparathyroidism (PHPT) and may lead to health-related quality of life (HRQL) improvements. We aim to evaluate general and disease-specific HRQL changes in patients undergoing surgery for PHPT from their perspective. Methods: Patients completed three patient-reported outcome measure (PROM) surveys before and after surgery: (1) Worry survey; (2) Voice Handicap Index-10 (VHI-10); and (3) Patient-Reported Outcome Measurement Information System Global-10 (PROMIS). Results: Forty-four patients were included with a median age of 65 years, with 39 females (89%) included. Thirty-two patients (73%) had a single adenoma, and 12 (27%) had multigland disease (parathyroid hyperplasia). Worry scores related to parathyroid cancer, parathyroid surgery, and parathyroid-related problems significantly improved post-operatively (p < 0.05). On PROMIS assessment, there were improved scores in the physical health domain, mental health domain, and general health following parathyroid surgery for PHPT (p < 0.05). Conclusion: Patients with PHPT demonstrated significant improvements in HRQL following surgery.

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organization
publishing date
type
Contribution to journal
publication status
in press
subject
keywords
parathyroid, PROM, quality, surgery, worry
in
Head and Neck
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:41392488
  • scopus:105024777633
ISSN
1043-3074
DOI
10.1002/hed.70129
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 Wiley Periodicals LLC.
id
0393461f-e137-45b3-801c-3637a35903d7
date added to LUP
2026-03-05 14:25:40
date last changed
2026-05-15 02:23:00
@article{0393461f-e137-45b3-801c-3637a35903d7,
  abstract     = {{<p>Background: Parathyroidectomy is typically curative for primary hyperparathyroidism (PHPT) and may lead to health-related quality of life (HRQL) improvements. We aim to evaluate general and disease-specific HRQL changes in patients undergoing surgery for PHPT from their perspective. Methods: Patients completed three patient-reported outcome measure (PROM) surveys before and after surgery: (1) Worry survey; (2) Voice Handicap Index-10 (VHI-10); and (3) Patient-Reported Outcome Measurement Information System Global-10 (PROMIS). Results: Forty-four patients were included with a median age of 65 years, with 39 females (89%) included. Thirty-two patients (73%) had a single adenoma, and 12 (27%) had multigland disease (parathyroid hyperplasia). Worry scores related to parathyroid cancer, parathyroid surgery, and parathyroid-related problems significantly improved post-operatively (p &lt; 0.05). On PROMIS assessment, there were improved scores in the physical health domain, mental health domain, and general health following parathyroid surgery for PHPT (p &lt; 0.05). Conclusion: Patients with PHPT demonstrated significant improvements in HRQL following surgery.</p>}},
  author       = {{Trinh, Lily N. and Okose, Okenwa C. and Abdelhamid-Ahmed, Amr H. and Saito, Yoshiyuki and Russell, Marika D. and Athni, Tejas S. and Karcioglu, Amanda Silver and Cheung, Anthony Y. and Srikanthan, Adithya and Alcaro, Christina and Sistovaris, Anthea and Behr, Ian J. and Soffer, Justin M. and Wang, Bo and Wong, Sam and Altan, Defne and Salem, Farhad and Zavaro, Elias and Maneeprasopchoke, Prachya and Larrabee, Katherine and Kamani, Dipti and Almquist, Martin and Triponez, Frédéric and Shin, Jennifer J. and Randolph, Gregory W.}},
  issn         = {{1043-3074}},
  keywords     = {{parathyroid; PROM; quality; surgery; worry}},
  language     = {{eng}},
  month        = {{11}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Head and Neck}},
  title        = {{Health-Related Quality of Life in Patients Undergoing Surgery for Primary Hyperparathyroidism : Patient Reported Outcome Measures}},
  url          = {{http://dx.doi.org/10.1002/hed.70129}},
  doi          = {{10.1002/hed.70129}},
  year         = {{2025}},
}