Characterization and modeling of acousto-optic signal strengths in highly scattering media
(2019) In Biomedical Optics Express 10(11). p.5565-5584- Abstract
Ultrasound optical tomography (UOT) is an imaging technique based on the acousto-optic effect that can perform optical imaging with ultrasound resolution inside turbid media, and is thus interesting for biomedical applications, e.g. for assessing tissue blood oxygenation. In this paper, we present near background free measurements of UOT signal strengths using slow light filter signal detection. We carefully analyze each part of our experimental setup and match measured signal strengths with calculations based on diffusion theory. This agreement between experiment and theory allows us to assert the deep tissue imaging potential of ∼ 5 cm for UOT of real human tissues predicted by previous theoretical studies [Biomed. Opt. Express 8,... (More)
Ultrasound optical tomography (UOT) is an imaging technique based on the acousto-optic effect that can perform optical imaging with ultrasound resolution inside turbid media, and is thus interesting for biomedical applications, e.g. for assessing tissue blood oxygenation. In this paper, we present near background free measurements of UOT signal strengths using slow light filter signal detection. We carefully analyze each part of our experimental setup and match measured signal strengths with calculations based on diffusion theory. This agreement between experiment and theory allows us to assert the deep tissue imaging potential of ∼ 5 cm for UOT of real human tissues predicted by previous theoretical studies [Biomed. Opt. Express 8, 4523 (2017)] with greater confidence, and indicate that future theoretical analysis of optimized UOT systems can be expected to be reliable.
(Less)
- author
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biomedical Optics Express
- volume
- 10
- issue
- 11
- pages
- 20 pages
- publisher
- Optical Society of America
- external identifiers
-
- pmid:31799031
- scopus:85078119267
- ISSN
- 2156-7085
- DOI
- 10.1364/BOE.10.005565
- language
- English
- LU publication?
- yes
- id
- 03ac2818-6c36-4a80-beea-c32f30b2eb35
- date added to LUP
- 2020-02-03 15:13:28
- date last changed
- 2024-06-13 11:40:27
@article{03ac2818-6c36-4a80-beea-c32f30b2eb35, abstract = {{<p>Ultrasound optical tomography (UOT) is an imaging technique based on the acousto-optic effect that can perform optical imaging with ultrasound resolution inside turbid media, and is thus interesting for biomedical applications, e.g. for assessing tissue blood oxygenation. In this paper, we present near background free measurements of UOT signal strengths using slow light filter signal detection. We carefully analyze each part of our experimental setup and match measured signal strengths with calculations based on diffusion theory. This agreement between experiment and theory allows us to assert the deep tissue imaging potential of ∼ 5 cm for UOT of real human tissues predicted by previous theoretical studies [Biomed. Opt. Express 8, 4523 (2017)] with greater confidence, and indicate that future theoretical analysis of optimized UOT systems can be expected to be reliable.</p>}}, author = {{Bengtsson, Alexander and Hill, David and Li, Meng and Di, Mengqiao and Cinthio, Magnus and Erlöv, Tobias and Andersson-Engels, Stefan and Reistad, Nina and Walther, Andreas and Rippe, Lars and Kröll, Stefan}}, issn = {{2156-7085}}, language = {{eng}}, number = {{11}}, pages = {{5565--5584}}, publisher = {{Optical Society of America}}, series = {{Biomedical Optics Express}}, title = {{Characterization and modeling of acousto-optic signal strengths in highly scattering media}}, url = {{http://dx.doi.org/10.1364/BOE.10.005565}}, doi = {{10.1364/BOE.10.005565}}, volume = {{10}}, year = {{2019}}, }