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Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T : Application to brain tumors

Zhou, Jinyuan ; Zaiss, Moritz ; Knutsson, Linda LU orcid ; Sun, Phillip Zhe ; Ahn, Sung Soo ; Aime, Silvio ; Bachert, Peter ; Blakeley, Jaishri O ; Cai, Kejia and Chappell, Michael A , et al. (2022) In Magnetic Resonance in Medicine 88(2). p.546-574
Abstract

Amide proton transfer-weighted (APTw) MR imaging shows promise as a biomarker of brain tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially among different institutes, and there are no agreed-on standards in the imaging community. Therefore, the results acquired from different research centers are difficult to compare, which hampers uniform clinical application and interpretation. This paper reviews current clinical APTw imaging approaches and provides a rationale for optimized APTw brain tumor imaging at 3 T, including specific recommendations for pulse sequences, acquisition protocols, and data processing methods. We expect that these consensus recommendations will become the first broadly accepted... (More)

Amide proton transfer-weighted (APTw) MR imaging shows promise as a biomarker of brain tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially among different institutes, and there are no agreed-on standards in the imaging community. Therefore, the results acquired from different research centers are difficult to compare, which hampers uniform clinical application and interpretation. This paper reviews current clinical APTw imaging approaches and provides a rationale for optimized APTw brain tumor imaging at 3 T, including specific recommendations for pulse sequences, acquisition protocols, and data processing methods. We expect that these consensus recommendations will become the first broadly accepted guidelines for APTw imaging of brain tumors on 3 T MRI systems from different vendors. This will allow more medical centers to use the same or comparable APTw MRI techniques for the detection, characterization, and monitoring of brain tumors, enabling multi-center trials in larger patient cohorts and, ultimately, routine clinical use.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Magnetic Resonance in Medicine
volume
88
issue
2
pages
546 - 574
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:35452155
  • scopus:85129010947
ISSN
1522-2594
DOI
10.1002/mrm.29241
language
English
LU publication?
yes
additional info
© 2022 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
id
0c9ba513-d295-4d67-8bba-6e94548217df
date added to LUP
2022-04-23 17:36:07
date last changed
2025-02-06 08:25:51
@article{0c9ba513-d295-4d67-8bba-6e94548217df,
  abstract     = {{<p>Amide proton transfer-weighted (APTw) MR imaging shows promise as a biomarker of brain tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially among different institutes, and there are no agreed-on standards in the imaging community. Therefore, the results acquired from different research centers are difficult to compare, which hampers uniform clinical application and interpretation. This paper reviews current clinical APTw imaging approaches and provides a rationale for optimized APTw brain tumor imaging at 3 T, including specific recommendations for pulse sequences, acquisition protocols, and data processing methods. We expect that these consensus recommendations will become the first broadly accepted guidelines for APTw imaging of brain tumors on 3 T MRI systems from different vendors. This will allow more medical centers to use the same or comparable APTw MRI techniques for the detection, characterization, and monitoring of brain tumors, enabling multi-center trials in larger patient cohorts and, ultimately, routine clinical use.</p>}},
  author       = {{Zhou, Jinyuan and Zaiss, Moritz and Knutsson, Linda and Sun, Phillip Zhe and Ahn, Sung Soo and Aime, Silvio and Bachert, Peter and Blakeley, Jaishri O and Cai, Kejia and Chappell, Michael A and Chen, Min and Gochberg, Daniel F and Goerke, Steffen and Heo, Hye-Young and Jiang, Shanshan and Jin, Tao and Kim, Seong-Gi and Laterra, John and Paech, Daniel and Pagel, Mark D and Park, Ji Eun and Reddy, Ravinder and Sakata, Akihiko and Sartoretti-Schefer, Sabine and Sherry, A Dean and Smith, Seth A and Stanisz, Greg J and Sundgren, Pia C and Togao, Osamu and Vandsburger, Moriel and Wen, Zhibo and Wu, Yin and Zhang, Yi and Zhu, Wenzhen and Zu, Zhongliang and van Zijl, Peter C M}},
  issn         = {{1522-2594}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{546--574}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Magnetic Resonance in Medicine}},
  title        = {{Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T : Application to brain tumors}},
  url          = {{http://dx.doi.org/10.1002/mrm.29241}},
  doi          = {{10.1002/mrm.29241}},
  volume       = {{88}},
  year         = {{2022}},
}