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Tracing Renal Cell Carcinomas back to the Nephron

Lindgren, David LU ; Sjölund, Jonas LU and Axelson, Håkan LU (2018) In Trends in Cancer 4(7). p.472-484
Abstract

Renal cell carcinomas (RCCs) are a heterogeneous group of tumors derived from the epithelial cells of the nephron. In recent years the genetic landscape of these tumors has been detailed, leading to progress in mouse modeling of the human disease. In parallel, substantial advancements have been made in describing the transcriptional programs of normal nephron cell types and how they respond to renal insults. Integrating these research fields may provide a deeper understanding of renal tumor initiation and progression, and provide leads that can be conveyed into mouse models that faithfully recapitulate the different RCC subtypes. We summarize here the genetic lesions and molecular pathways that define RCC subtypes and discuss how these... (More)

Renal cell carcinomas (RCCs) are a heterogeneous group of tumors derived from the epithelial cells of the nephron. In recent years the genetic landscape of these tumors has been detailed, leading to progress in mouse modeling of the human disease. In parallel, substantial advancements have been made in describing the transcriptional programs of normal nephron cell types and how they respond to renal insults. Integrating these research fields may provide a deeper understanding of renal tumor initiation and progression, and provide leads that can be conveyed into mouse models that faithfully recapitulate the different RCC subtypes. We summarize here the genetic lesions and molecular pathways that define RCC subtypes and discuss how these relate to cell-of-origin and renal repair programs.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Cancer
volume
4
issue
7
pages
472 - 484
publisher
Cell Press
external identifiers
  • scopus:85047956648
  • pmid:29937046
ISSN
2405-8033
DOI
10.1016/j.trecan.2018.05.003
language
English
LU publication?
yes
id
0e306556-2cb9-4b63-813a-7d946300b59c
date added to LUP
2018-06-15 13:36:13
date last changed
2024-06-24 15:56:09
@article{0e306556-2cb9-4b63-813a-7d946300b59c,
  abstract     = {{<p>Renal cell carcinomas (RCCs) are a heterogeneous group of tumors derived from the epithelial cells of the nephron. In recent years the genetic landscape of these tumors has been detailed, leading to progress in mouse modeling of the human disease. In parallel, substantial advancements have been made in describing the transcriptional programs of normal nephron cell types and how they respond to renal insults. Integrating these research fields may provide a deeper understanding of renal tumor initiation and progression, and provide leads that can be conveyed into mouse models that faithfully recapitulate the different RCC subtypes. We summarize here the genetic lesions and molecular pathways that define RCC subtypes and discuss how these relate to cell-of-origin and renal repair programs.</p>}},
  author       = {{Lindgren, David and Sjölund, Jonas and Axelson, Håkan}},
  issn         = {{2405-8033}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{472--484}},
  publisher    = {{Cell Press}},
  series       = {{Trends in Cancer}},
  title        = {{Tracing Renal Cell Carcinomas back to the Nephron}},
  url          = {{http://dx.doi.org/10.1016/j.trecan.2018.05.003}},
  doi          = {{10.1016/j.trecan.2018.05.003}},
  volume       = {{4}},
  year         = {{2018}},
}