Evidence for a GABA-mediated cerebellar inhibition of the inferior olive in the cat
(1988) In Experimental Brain Research 72(3). p.450-456- Abstract
- 1. Climbing fibres were activated by peripheral nerve stimulation at 'high' frequencies (greater than 3 Hz) for 15-25 s and then at 0.9 Hz for about 1 min. The high frequency activation induced a post-conditioning inhibition, lasting up to about 1 min, of climbing fibre responses recorded from the cerebellar surface. 2. Electrolytic lesions were made in the superior cerebellar peduncle (brachium conjunctivum). After the lesion, the post-conditioning inhibition was completely eliminated. 3. Injections of the GABA-receptor blocker bicuculline methiodide into the inferior olive reversibly blocked the post-conditioning inhibition. 4. The results support the hypothesis proposed by Andersson and Hesslow (1987a), that post-conditioning inhibition... (More)
- 1. Climbing fibres were activated by peripheral nerve stimulation at 'high' frequencies (greater than 3 Hz) for 15-25 s and then at 0.9 Hz for about 1 min. The high frequency activation induced a post-conditioning inhibition, lasting up to about 1 min, of climbing fibre responses recorded from the cerebellar surface. 2. Electrolytic lesions were made in the superior cerebellar peduncle (brachium conjunctivum). After the lesion, the post-conditioning inhibition was completely eliminated. 3. Injections of the GABA-receptor blocker bicuculline methiodide into the inferior olive reversibly blocked the post-conditioning inhibition. 4. The results support the hypothesis proposed by Andersson and Hesslow (1987a), that post-conditioning inhibition is mediated by a GABA-ergic interposito-olivary pathway. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1104245
- author
- Andersson, G ; Garwicz, Martin LU and Hesslow, Germund LU
- organization
- publishing date
- 1988
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cerebellum, Inferior olive, Interposito-olivary pathway, Brachium conjunctivum, GABA
- in
- Experimental Brain Research
- volume
- 72
- issue
- 3
- pages
- 450 - 456
- publisher
- Springer
- external identifiers
-
- pmid:3234498
- scopus:0023732776
- ISSN
- 0014-4819
- DOI
- 10.1007/BF00250590
- language
- English
- LU publication?
- yes
- id
- 0aaa3181-c251-4ea9-8392-0a21fa2bf9fd (old id 1104245)
- date added to LUP
- 2016-04-01 11:48:19
- date last changed
- 2021-09-19 05:13:40
@article{0aaa3181-c251-4ea9-8392-0a21fa2bf9fd, abstract = {{1. Climbing fibres were activated by peripheral nerve stimulation at 'high' frequencies (greater than 3 Hz) for 15-25 s and then at 0.9 Hz for about 1 min. The high frequency activation induced a post-conditioning inhibition, lasting up to about 1 min, of climbing fibre responses recorded from the cerebellar surface. 2. Electrolytic lesions were made in the superior cerebellar peduncle (brachium conjunctivum). After the lesion, the post-conditioning inhibition was completely eliminated. 3. Injections of the GABA-receptor blocker bicuculline methiodide into the inferior olive reversibly blocked the post-conditioning inhibition. 4. The results support the hypothesis proposed by Andersson and Hesslow (1987a), that post-conditioning inhibition is mediated by a GABA-ergic interposito-olivary pathway.}}, author = {{Andersson, G and Garwicz, Martin and Hesslow, Germund}}, issn = {{0014-4819}}, keywords = {{Cerebellum; Inferior olive; Interposito-olivary pathway; Brachium conjunctivum; GABA}}, language = {{eng}}, number = {{3}}, pages = {{450--456}}, publisher = {{Springer}}, series = {{Experimental Brain Research}}, title = {{Evidence for a GABA-mediated cerebellar inhibition of the inferior olive in the cat}}, url = {{http://dx.doi.org/10.1007/BF00250590}}, doi = {{10.1007/BF00250590}}, volume = {{72}}, year = {{1988}}, }