Antibody to a hepatitis C virus related protein among patients at high risk for hepatitis B
(1991) In Scandinavian Journal of Infectious Diseases 23(1). p.19-24- Abstract
- Anti-HCV prevalence in treated hemophiliacs, their heterosexual partners, intravenous drug addicts and homosexual men was studied. In hemophiliacs and many of the intravenous drug addicts, greater than or equal to 2 sera drawn 1-18 or 1-17 years apart were available. Anti-HCV testing was performed by ELISA (Ortho). Among patients with severe and moderate hemophilia A, 87% (98/112) were positive for anti-HCV at least once and among patients with severe and moderate hemophilia B, 83% (24/29) were positive for anti-HCV. Seroconversion to anti-HCV was observed in 21% of hemophilia patients. In hemophilia A, HCV infection generally occurred during the first years of life and in hemophilia B somewhat later. Loss of anti-HCV antibody was seen in... (More)
- Anti-HCV prevalence in treated hemophiliacs, their heterosexual partners, intravenous drug addicts and homosexual men was studied. In hemophiliacs and many of the intravenous drug addicts, greater than or equal to 2 sera drawn 1-18 or 1-17 years apart were available. Anti-HCV testing was performed by ELISA (Ortho). Among patients with severe and moderate hemophilia A, 87% (98/112) were positive for anti-HCV at least once and among patients with severe and moderate hemophilia B, 83% (24/29) were positive for anti-HCV. Seroconversion to anti-HCV was observed in 21% of hemophilia patients. In hemophilia A, HCV infection generally occurred during the first years of life and in hemophilia B somewhat later. Loss of anti-HCV antibody was seen in 12% (17 patients). The rest, 54% (76 patients) were seropositive in first and last samples. All 12 tested spouses to anti-HCV positive men were anti-HCV negative. 80% of the drug addicts (137/172) were seropositive for anti-HCV. In those with greater than 1 serum tested, 8% were consistently negative and 68% consistently positive. 21% seroconverted to anti-HCV while 3% lost antibody. 10% (22/211) of homosexual men were anti-HCV positive. Intravenous transmission of HCV thus seemed highly efficient whereas sexual transmission was much less efficient. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1105737
- author
- Widell, Anders LU ; Hansson, Bengt-Göran LU ; Berntorp, Erik LU ; Moestrup, Torkil ; Johansson, Hugo LU ; Hansson, Holger and Nordenfelt, Erik
- organization
- publishing date
- 1991
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Infectious Diseases
- volume
- 23
- issue
- 1
- pages
- 19 - 24
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:1851322
- scopus:0025967827
- ISSN
- 1651-1980
- DOI
- 10.3109/00365549109023369
- language
- English
- LU publication?
- yes
- id
- 5c4f6cfe-8227-4d17-8b1b-b386dfe01f85 (old id 1105737)
- date added to LUP
- 2016-04-01 16:45:48
- date last changed
- 2021-08-29 04:01:08
@article{5c4f6cfe-8227-4d17-8b1b-b386dfe01f85, abstract = {{Anti-HCV prevalence in treated hemophiliacs, their heterosexual partners, intravenous drug addicts and homosexual men was studied. In hemophiliacs and many of the intravenous drug addicts, greater than or equal to 2 sera drawn 1-18 or 1-17 years apart were available. Anti-HCV testing was performed by ELISA (Ortho). Among patients with severe and moderate hemophilia A, 87% (98/112) were positive for anti-HCV at least once and among patients with severe and moderate hemophilia B, 83% (24/29) were positive for anti-HCV. Seroconversion to anti-HCV was observed in 21% of hemophilia patients. In hemophilia A, HCV infection generally occurred during the first years of life and in hemophilia B somewhat later. Loss of anti-HCV antibody was seen in 12% (17 patients). The rest, 54% (76 patients) were seropositive in first and last samples. All 12 tested spouses to anti-HCV positive men were anti-HCV negative. 80% of the drug addicts (137/172) were seropositive for anti-HCV. In those with greater than 1 serum tested, 8% were consistently negative and 68% consistently positive. 21% seroconverted to anti-HCV while 3% lost antibody. 10% (22/211) of homosexual men were anti-HCV positive. Intravenous transmission of HCV thus seemed highly efficient whereas sexual transmission was much less efficient.}}, author = {{Widell, Anders and Hansson, Bengt-Göran and Berntorp, Erik and Moestrup, Torkil and Johansson, Hugo and Hansson, Holger and Nordenfelt, Erik}}, issn = {{1651-1980}}, language = {{eng}}, number = {{1}}, pages = {{19--24}}, publisher = {{Informa Healthcare}}, series = {{Scandinavian Journal of Infectious Diseases}}, title = {{Antibody to a hepatitis C virus related protein among patients at high risk for hepatitis B}}, url = {{http://dx.doi.org/10.3109/00365549109023369}}, doi = {{10.3109/00365549109023369}}, volume = {{23}}, year = {{1991}}, }