Anti-inflammatory properties of titanium in the joint environment. An experimental study in rats
(1998) In Journal of Bone and Joint Surgery: British Volume 80-B(5). p.888-893- Abstract
- Little is known about the tissue reactions to various implant materials which coincide with an inflammatory reaction. We used the avridine arthritis rat model to evaluate the tissue response in the synovial, interstitial and subcutaneous tissues after implant insertion. Quantitative immunohistochemistry showed that normal joint synovial tissue is dominated by ED2-positive resident macrophages. Polyethylene implants induced a much stronger foreign-body reaction than titanium implants, as measured by the number of interfacial ED1-positive macrophages. The tissue response to titanium and polyethylene was also vastly different in arthritic synovial tissue compared with control tissue. It is likely that these biomaterials interact differently... (More)
- Little is known about the tissue reactions to various implant materials which coincide with an inflammatory reaction. We used the avridine arthritis rat model to evaluate the tissue response in the synovial, interstitial and subcutaneous tissues after implant insertion. Quantitative immunohistochemistry showed that normal joint synovial tissue is dominated by ED2-positive resident macrophages. Polyethylene implants induced a much stronger foreign-body reaction than titanium implants, as measured by the number of interfacial ED1-positive macrophages. The tissue response to titanium and polyethylene was also vastly different in arthritic synovial tissue compared with control tissue. It is likely that these biomaterials interact differently with inflammatory cells or intermediary compounds. It may be that arthritic synovial tissue produces reactive oxygen intermediates (free radicals) with which titanium has a unique anti-inflammatory interaction in vitro. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1112785
- author
- Overgaard, Lars ; Danielsen, Nils LU and Bjursten, Lars Magnus LU
- organization
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Bone and Joint Surgery: British Volume
- volume
- 80-B
- issue
- 5
- pages
- 888 - 893
- publisher
- British Editorial Society of Bone & Joint Surgery
- external identifiers
-
- pmid:9768904
- ISSN
- 2044-5377
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Bioimplant Research (013242910), Neural Interfaces (013212003)
- id
- 2a2d5088-2c9e-4912-835e-7a48017637e7 (old id 1112785)
- alternative location
- http://www.jbjs.org.uk/cgi/reprint/80-B/5/894
- date added to LUP
- 2016-04-01 12:13:08
- date last changed
- 2018-11-21 20:05:06
@article{2a2d5088-2c9e-4912-835e-7a48017637e7,
abstract = {{Little is known about the tissue reactions to various implant materials which coincide with an inflammatory reaction. We used the avridine arthritis rat model to evaluate the tissue response in the synovial, interstitial and subcutaneous tissues after implant insertion. Quantitative immunohistochemistry showed that normal joint synovial tissue is dominated by ED2-positive resident macrophages. Polyethylene implants induced a much stronger foreign-body reaction than titanium implants, as measured by the number of interfacial ED1-positive macrophages. The tissue response to titanium and polyethylene was also vastly different in arthritic synovial tissue compared with control tissue. It is likely that these biomaterials interact differently with inflammatory cells or intermediary compounds. It may be that arthritic synovial tissue produces reactive oxygen intermediates (free radicals) with which titanium has a unique anti-inflammatory interaction in vitro.}},
author = {{Overgaard, Lars and Danielsen, Nils and Bjursten, Lars Magnus}},
issn = {{2044-5377}},
language = {{eng}},
number = {{5}},
pages = {{888--893}},
publisher = {{British Editorial Society of Bone & Joint Surgery}},
series = {{Journal of Bone and Joint Surgery: British Volume}},
title = {{Anti-inflammatory properties of titanium in the joint environment. An experimental study in rats}},
url = {{http://www.jbjs.org.uk/cgi/reprint/80-B/5/894}},
volume = {{80-B}},
year = {{1998}},
}