Bone mineral density in patients with Crohn's disease during long-term treatment with azathioprine
(1998) In Journal of Internal Medicine 243(2). p.123-126- Abstract
- OBJECTIVES: To ascertain whether patients with Crohn's disease treated with azathioprine maintained bone mineral mass better than patients treated with steroids alone. DESIGN: Retrospective study. SETTING: University Hospital of Malmo, Sweden. SUBJECTS: A total of 59 patients with ileocolonic, ileocaecal or colonic Crohn's disease. METHODS: Bone mass was assessed by dual photon X-ray absorptiometry at the level of L2-L4. RESULTS: Patients treated with a high lifetime dose of steroids (> 5 g prednisolone) had significantly (P = 0.011) lower Z-score of L2-L4 (-0.87 +/- 1.11; 11 SD) than steroid-treated patients, who had received a low dose of prednisolone (< 5 g) (0.08 +/- 1.16 SD). Azathioprine did not negatively influence the steroid... (More)
- OBJECTIVES: To ascertain whether patients with Crohn's disease treated with azathioprine maintained bone mineral mass better than patients treated with steroids alone. DESIGN: Retrospective study. SETTING: University Hospital of Malmo, Sweden. SUBJECTS: A total of 59 patients with ileocolonic, ileocaecal or colonic Crohn's disease. METHODS: Bone mass was assessed by dual photon X-ray absorptiometry at the level of L2-L4. RESULTS: Patients treated with a high lifetime dose of steroids (> 5 g prednisolone) had significantly (P = 0.011) lower Z-score of L2-L4 (-0.87 +/- 1.11; 11 SD) than steroid-treated patients, who had received a low dose of prednisolone (< 5 g) (0.08 +/- 1.16 SD). Azathioprine did not negatively influence the steroid effect on bone mineral density. CONCLUSIONS: Azathioprine does not seem to affect bone mineral density by itself. However, by being steroid-saving, it seems to conserve bone mineral mass in patients with Crohn's disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1113206
- author
- Florén, Claes-Henrik LU ; Ahrén, Bo LU ; Bengtsson, M ; Bartosik, Jacek LU and Obrant, Karl LU
- organization
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- azathioprine, bone mineral density, corticosteroids, Crohn's disease, prednisolone
- in
- Journal of Internal Medicine
- volume
- 243
- issue
- 2
- pages
- 123 - 126
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:9566640
- scopus:0031960528
- ISSN
- 1365-2796
- language
- English
- LU publication?
- yes
- id
- f7f4f1ae-2edd-4610-9195-479cbbc4c604 (old id 1113206)
- date added to LUP
- 2016-04-01 16:27:19
- date last changed
- 2024-01-04 22:15:08
@article{f7f4f1ae-2edd-4610-9195-479cbbc4c604, abstract = {{OBJECTIVES: To ascertain whether patients with Crohn's disease treated with azathioprine maintained bone mineral mass better than patients treated with steroids alone. DESIGN: Retrospective study. SETTING: University Hospital of Malmo, Sweden. SUBJECTS: A total of 59 patients with ileocolonic, ileocaecal or colonic Crohn's disease. METHODS: Bone mass was assessed by dual photon X-ray absorptiometry at the level of L2-L4. RESULTS: Patients treated with a high lifetime dose of steroids (> 5 g prednisolone) had significantly (P = 0.011) lower Z-score of L2-L4 (-0.87 +/- 1.11; 11 SD) than steroid-treated patients, who had received a low dose of prednisolone (< 5 g) (0.08 +/- 1.16 SD). Azathioprine did not negatively influence the steroid effect on bone mineral density. CONCLUSIONS: Azathioprine does not seem to affect bone mineral density by itself. However, by being steroid-saving, it seems to conserve bone mineral mass in patients with Crohn's disease.}}, author = {{Florén, Claes-Henrik and Ahrén, Bo and Bengtsson, M and Bartosik, Jacek and Obrant, Karl}}, issn = {{1365-2796}}, keywords = {{azathioprine; bone mineral density; corticosteroids; Crohn's disease; prednisolone}}, language = {{eng}}, number = {{2}}, pages = {{123--126}}, publisher = {{Wiley-Blackwell}}, series = {{Journal of Internal Medicine}}, title = {{Bone mineral density in patients with Crohn's disease during long-term treatment with azathioprine}}, volume = {{243}}, year = {{1998}}, }