Factor V Q506 (resistance to activated protein C) and prognosis after acute coronary syndrome
(1999) In Thrombosis and Haemostasis 81(6). p.857-860- Abstract
- Factor V:Q506 causing resistance to activated protein C (APC-resistance), is a risk factor for venous thrombosis. Some studies have indicated an association with arterial disease, especially in women. We investigated the prevalence of the FV:Q506 allele prospectively in 295 patients with acute coronary syndrome. Mortality and myocardial infarction rate were evaluated after 30 days and after 2 years. The FV:Q506 allele was found in 38 patients. In a Cox proportional hazards model, smokers carrying FV:Q506 had a higher risk of infarction or death within 30 days, compared to non-smokers with a normal genotype (relative risk 2.9 [95% CI 1.2-7.0]). The difference remained significant after 2 years (relative risk 2.8 [95% CI 1.2-6.5]). The... (More)
- Factor V:Q506 causing resistance to activated protein C (APC-resistance), is a risk factor for venous thrombosis. Some studies have indicated an association with arterial disease, especially in women. We investigated the prevalence of the FV:Q506 allele prospectively in 295 patients with acute coronary syndrome. Mortality and myocardial infarction rate were evaluated after 30 days and after 2 years. The FV:Q506 allele was found in 38 patients. In a Cox proportional hazards model, smokers carrying FV:Q506 had a higher risk of infarction or death within 30 days, compared to non-smokers with a normal genotype (relative risk 2.9 [95% CI 1.2-7.0]). The difference remained significant after 2 years (relative risk 2.8 [95% CI 1.2-6.5]). The effect of the FV:Q506 allele on clinical outcome in acute coronary syndrome has not previously been described. Our results demonstrate a gene-environment interaction between smoking and the FV:Q506 allele, with an increased risk of early complications after an acute ischemic event. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1114915
- author
- Holm, Johan LU ; Hillarp, Andreas LU ; Zöller, Bengt LU ; Erhardt, Leif RW LU ; Berntorp, Erik LU and Dahlbäck, Björn LU
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Activated Protein C Resistance, Acute Disease, Aged, Alleles, Coronary Disease, Factor V, Female, Humans, Male, Middle Aged, Mutation, Polymorphism, Genetic, Prevalence, Prognosis, Risk Factors, Journal Article, Research Support, Non-U.S. Gov't
- in
- Thrombosis and Haemostasis
- volume
- 81
- issue
- 6
- pages
- 4 pages
- publisher
- Schattauer GmbH
- external identifiers
-
- pmid:10404756
- scopus:0033143554
- pmid:10404756
- ISSN
- 0340-6245
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Internal Medicine Research Unit (013242520), Clinical Chemistry, Malmö (013016000), Clinical Coagulation Research Unit (013242510), Emergency medicine/Medicine/Surgery (013240200)
- id
- 5b4de8b9-a9fd-4478-81a7-cc51163141a3 (old id 1114915)
- date added to LUP
- 2016-04-01 16:38:49
- date last changed
- 2022-01-28 21:06:50
@article{5b4de8b9-a9fd-4478-81a7-cc51163141a3, abstract = {{Factor V:Q506 causing resistance to activated protein C (APC-resistance), is a risk factor for venous thrombosis. Some studies have indicated an association with arterial disease, especially in women. We investigated the prevalence of the FV:Q506 allele prospectively in 295 patients with acute coronary syndrome. Mortality and myocardial infarction rate were evaluated after 30 days and after 2 years. The FV:Q506 allele was found in 38 patients. In a Cox proportional hazards model, smokers carrying FV:Q506 had a higher risk of infarction or death within 30 days, compared to non-smokers with a normal genotype (relative risk 2.9 [95% CI 1.2-7.0]). The difference remained significant after 2 years (relative risk 2.8 [95% CI 1.2-6.5]). The effect of the FV:Q506 allele on clinical outcome in acute coronary syndrome has not previously been described. Our results demonstrate a gene-environment interaction between smoking and the FV:Q506 allele, with an increased risk of early complications after an acute ischemic event.}}, author = {{Holm, Johan and Hillarp, Andreas and Zöller, Bengt and Erhardt, Leif RW and Berntorp, Erik and Dahlbäck, Björn}}, issn = {{0340-6245}}, keywords = {{Activated Protein C Resistance; Acute Disease; Aged; Alleles; Coronary Disease; Factor V; Female; Humans; Male; Middle Aged; Mutation; Polymorphism, Genetic; Prevalence; Prognosis; Risk Factors; Journal Article; Research Support, Non-U.S. Gov't}}, language = {{eng}}, number = {{6}}, pages = {{857--860}}, publisher = {{Schattauer GmbH}}, series = {{Thrombosis and Haemostasis}}, title = {{Factor V Q506 (resistance to activated protein C) and prognosis after acute coronary syndrome}}, volume = {{81}}, year = {{1999}}, }