Neuropathological correlates to clinically defined dementia with Lewy bodies
(2001) In International Journal of Geriatric Psychiatry 16(7). p.667-679- Abstract
- OBJECTIVES: To analyse the neuropathological changes behind clinically defined dementia with Lewy bodies (clinDLB) compared with clinically diagnosed Alzheimer's disease (clinAD). METHODS: The prevalence of neuropathological findings in 48 clinDLB and 45 clinAD cases was compared. Sixteen clinDLB and 10 clinAD cases were reassessed with alpha-synuclein staining for Lewy bodies (LB). RESULTS: Alzheimer pathology was found in 81% of the clinDLB and 93% of the clinAD cases. The clinDLB group had a higher prevalence of frontal white matter pathology, mostly of ischemic type, and a more severe degeneration of the substantia nigra compared with the clinAD group. In hematoxylin-eosin staining, LBs were identified in seven (15%) of the clinDLB and... (More)
- OBJECTIVES: To analyse the neuropathological changes behind clinically defined dementia with Lewy bodies (clinDLB) compared with clinically diagnosed Alzheimer's disease (clinAD). METHODS: The prevalence of neuropathological findings in 48 clinDLB and 45 clinAD cases was compared. Sixteen clinDLB and 10 clinAD cases were reassessed with alpha-synuclein staining for Lewy bodies (LB). RESULTS: Alzheimer pathology was found in 81% of the clinDLB and 93% of the clinAD cases. The clinDLB group had a higher prevalence of frontal white matter pathology, mostly of ischemic type, and a more severe degeneration of the substantia nigra compared with the clinAD group. In hematoxylin-eosin staining, LBs were identified in seven (15%) of the clinDLB and in four (9%) of the clinAD group. In alpha-synuclein staining, 38% of the clinDLB and 40% of the clinAD cases exhibited LBs. The cases without LBs, in the clinDLB group, had AD pathology in combination with frontal white matter disease. Vascular pathology of significant degree was prevalent in more than 40% of all the cases with verified LBs regardless of clinical diagnosis. CONCLUSION: Consecutive dementia cases, fulfilling the clinical consensus criteria for DLB, may exhibit combinations of neuropathological changes which in themselves can explain the clinical picture of DLB even when LBs are absent. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1121707
- author
- Londos, Elisabet LU ; Passant, Ulla LU ; Gustafson, Lars LU and Brun, Arne LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Lewy body dementia, Alzheimer pathology, white matter disease, Alzheimer's disease, substantia nigra, vascular pathology, neuropathology
- in
- International Journal of Geriatric Psychiatry
- volume
- 16
- issue
- 7
- pages
- 667 - 679
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:11466745
- scopus:0034864708
- ISSN
- 1099-1166
- DOI
- 10.1002/gps.403
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Psychogeriatrics (013304000), Psychiatry/Primary Care/Public Health (013240500), Clinical Memory Research Unit (013242610), Division IV (013230800)
- id
- 758c133c-8db3-441e-bd62-5c340eae7c3c (old id 1121707)
- date added to LUP
- 2016-04-01 11:43:34
- date last changed
- 2022-04-05 03:57:46
@article{758c133c-8db3-441e-bd62-5c340eae7c3c, abstract = {{OBJECTIVES: To analyse the neuropathological changes behind clinically defined dementia with Lewy bodies (clinDLB) compared with clinically diagnosed Alzheimer's disease (clinAD). METHODS: The prevalence of neuropathological findings in 48 clinDLB and 45 clinAD cases was compared. Sixteen clinDLB and 10 clinAD cases were reassessed with alpha-synuclein staining for Lewy bodies (LB). RESULTS: Alzheimer pathology was found in 81% of the clinDLB and 93% of the clinAD cases. The clinDLB group had a higher prevalence of frontal white matter pathology, mostly of ischemic type, and a more severe degeneration of the substantia nigra compared with the clinAD group. In hematoxylin-eosin staining, LBs were identified in seven (15%) of the clinDLB and in four (9%) of the clinAD group. In alpha-synuclein staining, 38% of the clinDLB and 40% of the clinAD cases exhibited LBs. The cases without LBs, in the clinDLB group, had AD pathology in combination with frontal white matter disease. Vascular pathology of significant degree was prevalent in more than 40% of all the cases with verified LBs regardless of clinical diagnosis. CONCLUSION: Consecutive dementia cases, fulfilling the clinical consensus criteria for DLB, may exhibit combinations of neuropathological changes which in themselves can explain the clinical picture of DLB even when LBs are absent.}}, author = {{Londos, Elisabet and Passant, Ulla and Gustafson, Lars and Brun, Arne}}, issn = {{1099-1166}}, keywords = {{Lewy body dementia; Alzheimer pathology; white matter disease; Alzheimer's disease; substantia nigra; vascular pathology; neuropathology}}, language = {{eng}}, number = {{7}}, pages = {{667--679}}, publisher = {{John Wiley & Sons Inc.}}, series = {{International Journal of Geriatric Psychiatry}}, title = {{Neuropathological correlates to clinically defined dementia with Lewy bodies}}, url = {{http://dx.doi.org/10.1002/gps.403}}, doi = {{10.1002/gps.403}}, volume = {{16}}, year = {{2001}}, }