Smoking and lymphoma risk in the european prospective investigation into cancer and nutrition
(2008) In American Journal of Epidemiology 167(9). p.1081-1089- Abstract
- Lymphomas are one of the few cancers that have been increasing in incidence over the past decades. So far, only a few established risk factors have been identified, including immunosuppression and viral infections. Recent evidence suggests etiologic heterogeneity of different lymphoma subtypes. Smoking may affect risk differently, depending on the lymphoma entity. The European Prospective Investigation into Cancer and Nutrition was used to study the role of smoking in the etiology of lymphomas and individual subtypes within a prospective study. Information on baseline and lifetime tobacco smoking by 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted... (More)
- Lymphomas are one of the few cancers that have been increasing in incidence over the past decades. So far, only a few established risk factors have been identified, including immunosuppression and viral infections. Recent evidence suggests etiologic heterogeneity of different lymphoma subtypes. Smoking may affect risk differently, depending on the lymphoma entity. The European Prospective Investigation into Cancer and Nutrition was used to study the role of smoking in the etiology of lymphomas and individual subtypes within a prospective study. Information on baseline and lifetime tobacco smoking by 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. During 3,567,410 person-years of follow-up, 1,371 lymphoma cases (1,304 non-Hodgkin's lymphomas and 67 Hodgkin's lymphomas) were identified. Relative risk for smokers at recruitment was more than twofold higher for Hodgkin's lymphoma (hazard ratio = 2.14, 95% confidence interval: 1.18, 3.87) but was not elevated for non-Hodgkin's lymphoma (hazard ratio = 1.06, 95% confidence interval: 0.94, 1.19) and individual B-cell non-Hodgkin's lymphoma subtypes. In this prospective study, smoking appeared to increase Hodgkin's lymphoma risk consistently in both genders, whereas B-cell non-Hodgkin's lymphoma risk was not associated. Future analysis should involve viral biomarkers and genetic susceptibility markers to elucidate potential mechanisms of smoking-induced carcinogenesis, particularly for Hodgkin's lymphoma. (Less)
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https://lup.lub.lu.se/record/1205398
- author
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- prospective studies, lymphoma, risk factors, smoking
- in
- American Journal of Epidemiology
- volume
- 167
- issue
- 9
- pages
- 1081 - 1089
- publisher
- Oxford University Press
- external identifiers
-
- wos:000255310200008
- scopus:42649144776
- ISSN
- 0002-9262
- DOI
- 10.1093/aje/kwn004
- language
- English
- LU publication?
- yes
- id
- a97bdd2b-7d58-4320-a1fd-c0f3d91b60a8 (old id 1205398)
- date added to LUP
- 2016-04-01 12:38:16
- date last changed
- 2022-01-27 07:50:24
@article{a97bdd2b-7d58-4320-a1fd-c0f3d91b60a8,
abstract = {{Lymphomas are one of the few cancers that have been increasing in incidence over the past decades. So far, only a few established risk factors have been identified, including immunosuppression and viral infections. Recent evidence suggests etiologic heterogeneity of different lymphoma subtypes. Smoking may affect risk differently, depending on the lymphoma entity. The European Prospective Investigation into Cancer and Nutrition was used to study the role of smoking in the etiology of lymphomas and individual subtypes within a prospective study. Information on baseline and lifetime tobacco smoking by 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. During 3,567,410 person-years of follow-up, 1,371 lymphoma cases (1,304 non-Hodgkin's lymphomas and 67 Hodgkin's lymphomas) were identified. Relative risk for smokers at recruitment was more than twofold higher for Hodgkin's lymphoma (hazard ratio = 2.14, 95% confidence interval: 1.18, 3.87) but was not elevated for non-Hodgkin's lymphoma (hazard ratio = 1.06, 95% confidence interval: 0.94, 1.19) and individual B-cell non-Hodgkin's lymphoma subtypes. In this prospective study, smoking appeared to increase Hodgkin's lymphoma risk consistently in both genders, whereas B-cell non-Hodgkin's lymphoma risk was not associated. Future analysis should involve viral biomarkers and genetic susceptibility markers to elucidate potential mechanisms of smoking-induced carcinogenesis, particularly for Hodgkin's lymphoma.}},
author = {{Nieters, Alexandra and Rohrmann, Sabine and Becker, Nikolaus and Linseisen, Jakob and Ruediger, Thomas and Overvad, Kim and Tjonneland, Anne and Olsen, Anja and Allen, Naomi E. and Travis, Ruth C. and Bingham, Sheila and Khaw, Kay-Tee and Ardanaz, Eva and Redondo, M. L. and Basterrechea, Mikel and Martinez, Carmen and Tormo, Maria-Jose and Rosso, Stefano and Tagliabue, Giovanna and Masala, Giovanna and Mattiello, Amalia and Tumino, Rosario and Boeing, Heiner and Bergmann, Manuela and Kaaks, Rudolf and Trichopoulou, Antonia and Trichopoulos, Dimitrios and Peeters, Petra H. and Bueno-de-Mesquita, Bas and Boffetta, Paolo and Brennan, Paul and Ferrari, Pietro and Neasham, David and Lund, Eiliv and Berglund, Göran and Manjer, Jonas and Hallmans, Göran and Johansson, Ingegerd and Vineis, Paolo and Riboli, Elio}},
issn = {{0002-9262}},
keywords = {{prospective studies; lymphoma; risk factors; smoking}},
language = {{eng}},
number = {{9}},
pages = {{1081--1089}},
publisher = {{Oxford University Press}},
series = {{American Journal of Epidemiology}},
title = {{Smoking and lymphoma risk in the european prospective investigation into cancer and nutrition}},
url = {{http://dx.doi.org/10.1093/aje/kwn004}},
doi = {{10.1093/aje/kwn004}},
volume = {{167}},
year = {{2008}},
}