Model-free arterial spin labelling for cerebral blood flow quantification: introduction of regional arterial input functions identified by factor analysis.
Knutsson, Linda LU
; Bloch, Karin M
LU
; Holtås, Stig
LU
; Wirestam, Ronnie
LU
and Ståhlberg, Freddy
LU
(2008)
In Magnetic Resonance Imaging
26(4).
p.554-559
- Abstract
- PURPOSE: To identify regional arterial input functions (AIFs) using factor analysis of dynamic studies (FADS) when quantification of perfusion is performed using model-free arterial spin labelling. MATERIAL AND METHODS: Five healthy volunteers and one patient were examined on a 3-T Philips unit using quantitative STAR labelling of arterial regions (QUASAR). Two sets of images were retrieved, one where the arterial signal had been crushed and another where it was retained. FADS was applied to the arterial signal curves to acquire the AIFs. Perfusion maps were obtained using block-circulant SVD deconvolution and regional AIFs obtained by FADS. In the volunteers, the ASL experiment was repeated within 24 h. The patient was also examined using... (More)
- PURPOSE: To identify regional arterial input functions (AIFs) using factor analysis of dynamic studies (FADS) when quantification of perfusion is performed using model-free arterial spin labelling. MATERIAL AND METHODS: Five healthy volunteers and one patient were examined on a 3-T Philips unit using quantitative STAR labelling of arterial regions (QUASAR). Two sets of images were retrieved, one where the arterial signal had been crushed and another where it was retained. FADS was applied to the arterial signal curves to acquire the AIFs. Perfusion maps were obtained using block-circulant SVD deconvolution and regional AIFs obtained by FADS. In the volunteers, the ASL experiment was repeated within 24 h. The patient was also examined using dynamic susceptibility contrast MRI. RESULTS: In the healthy volunteers, CBF was 64+/-10 ml/[min 100 g] (mean+/-S.D.) in GM and 24+/-4 ml/[min 100 g] in WM, while the mean aBV was 0.94% in GM and 0.25% in WM. DISCUSSION: Good CBF image quality and reasonable quantitative CBF values were obtained using the combined QUASAR/FADS technique. We conclude that FADS may be a useful supplement in the evaluation of ASL data using QUASAR. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1314981
- author
- Knutsson, Linda
LU
; Bloch, Karin M
LU
; Holtås, Stig
LU
; Wirestam, Ronnie
LU
and Ståhlberg, Freddy
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Magnetic Resonance Imaging
- volume
- 26
- issue
- 4
- pages
- 554 - 559
- publisher
- Elsevier
- external identifiers
-
- pmid:18060721
- wos:000255299100013
- scopus:41949102012
- ISSN
- 1873-5894
- DOI
- 10.1016/j.mri.2007.10.006
- project
- MRI brain perfusion quantification at 3 tesla using arterial spin labeling
- language
- English
- LU publication?
- yes
- id
- fd9980f7-82d4-41f2-9094-f89e423b3510 (old id 1314981)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18060721?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
- date added to LUP
- 2016-04-01 11:55:37
- date last changed
- 2022-01-26 20:16:11
@article{fd9980f7-82d4-41f2-9094-f89e423b3510,
abstract = {{PURPOSE: To identify regional arterial input functions (AIFs) using factor analysis of dynamic studies (FADS) when quantification of perfusion is performed using model-free arterial spin labelling. MATERIAL AND METHODS: Five healthy volunteers and one patient were examined on a 3-T Philips unit using quantitative STAR labelling of arterial regions (QUASAR). Two sets of images were retrieved, one where the arterial signal had been crushed and another where it was retained. FADS was applied to the arterial signal curves to acquire the AIFs. Perfusion maps were obtained using block-circulant SVD deconvolution and regional AIFs obtained by FADS. In the volunteers, the ASL experiment was repeated within 24 h. The patient was also examined using dynamic susceptibility contrast MRI. RESULTS: In the healthy volunteers, CBF was 64+/-10 ml/[min 100 g] (mean+/-S.D.) in GM and 24+/-4 ml/[min 100 g] in WM, while the mean aBV was 0.94% in GM and 0.25% in WM. DISCUSSION: Good CBF image quality and reasonable quantitative CBF values were obtained using the combined QUASAR/FADS technique. We conclude that FADS may be a useful supplement in the evaluation of ASL data using QUASAR.}},
author = {{Knutsson, Linda and Bloch, Karin M and Holtås, Stig and Wirestam, Ronnie and Ståhlberg, Freddy}},
issn = {{1873-5894}},
language = {{eng}},
number = {{4}},
pages = {{554--559}},
publisher = {{Elsevier}},
series = {{Magnetic Resonance Imaging}},
title = {{Model-free arterial spin labelling for cerebral blood flow quantification: introduction of regional arterial input functions identified by factor analysis.}},
url = {{http://dx.doi.org/10.1016/j.mri.2007.10.006}},
doi = {{10.1016/j.mri.2007.10.006}},
volume = {{26}},
year = {{2008}},
}