Role of the FOXC2 -512C>T polymorphism in type 2 diabetes: possible association with the dysmetabolic syndrome.
Nilsson, Emma A LU
; Groop, Leif
LU
and Ridderstråle, Martin
LU
(2005)
In International Journal of Obesity
29(Dec 14).
p.268-274
- Abstract
- OBJECTIVE: Overexpression of the human transcription factor FOXC2 gene ( FOXC2) protects against insulin resistance in mice and a common FOXC2 polymorphism (-512C > T) has been suggested to be associated with insulin resistance in humans. Here, we addressed the potential role for FOXC2 as a candidate gene for type 2 diabetes and associated phenotypes. MATERIALS AND METHODS: A case-control study was performed in 390 type 2 diabetic patients and 307 control subjects. The number of patients was increased to a total of 768 subjects for further study of phenotypic differences relating to the dysmetabolic syndrome relative to genetic variation. The FOXC2 -512C > T polymorphism was genotyped by a restriction fragment length polymorphism PCR... (More)
- OBJECTIVE: Overexpression of the human transcription factor FOXC2 gene ( FOXC2) protects against insulin resistance in mice and a common FOXC2 polymorphism (-512C > T) has been suggested to be associated with insulin resistance in humans. Here, we addressed the potential role for FOXC2 as a candidate gene for type 2 diabetes and associated phenotypes. MATERIALS AND METHODS: A case-control study was performed in 390 type 2 diabetic patients and 307 control subjects. The number of patients was increased to a total of 768 subjects for further study of phenotypic differences relating to the dysmetabolic syndrome relative to genetic variation. The FOXC2 -512C > T polymorphism was genotyped by a restriction fragment length polymorphism PCR assay. RESULTS: FOXC2 -512C > T allele and genotype distribution did not differ between patients with type 2 diabetes and control subjects, but the C/C genotype was associated with increased body mass index (BMI, kg/m(2)) (P-a = 0.03) among type 2 diabetic patients. The FOXC2 -512C > T polymorphism was a significant independent predictor of BMI (P = 0.001) in a multiple regression model including age, gender and affection status. We found no significant association with type 2 diabetes-related metabolic parameters but that the C-allele (P = 0.01) and C/C and C/T genotypes (P = 0.03) were significantly over-represented in type 2 diabetic males with a concomitant diagnosis of dysmetabolic syndrome. CONCLUSION: We conclude that FOXC2 is associated with obesity and metabolic deterioration but does not contribute to an increased risk for type 2 diabetes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/132039
- author
- Nilsson, Emma A
LU
; Groop, Leif
LU
and Ridderstråle, Martin
LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- case-control association study, dysmetabolic syndrome, type 2 diabetes, noninsulin-dependent diabetes, forkhead transcription factor
- in
- International Journal of Obesity
- volume
- 29
- issue
- Dec 14
- pages
- 268 - 274
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000226981400003
- pmid:15597109
- scopus:14744289046
- ISSN
- 1476-5497
- DOI
- 10.1038/sj.ijo.0802876
- language
- English
- LU publication?
- yes
- id
- 73214424-f94a-4b9a-a023-29047b5a7a56 (old id 132039)
- date added to LUP
- 2016-04-01 12:35:07
- date last changed
- 2024-01-09 01:42:38
@article{73214424-f94a-4b9a-a023-29047b5a7a56,
abstract = {{OBJECTIVE: Overexpression of the human transcription factor FOXC2 gene ( FOXC2) protects against insulin resistance in mice and a common FOXC2 polymorphism (-512C > T) has been suggested to be associated with insulin resistance in humans. Here, we addressed the potential role for FOXC2 as a candidate gene for type 2 diabetes and associated phenotypes. MATERIALS AND METHODS: A case-control study was performed in 390 type 2 diabetic patients and 307 control subjects. The number of patients was increased to a total of 768 subjects for further study of phenotypic differences relating to the dysmetabolic syndrome relative to genetic variation. The FOXC2 -512C > T polymorphism was genotyped by a restriction fragment length polymorphism PCR assay. RESULTS: FOXC2 -512C > T allele and genotype distribution did not differ between patients with type 2 diabetes and control subjects, but the C/C genotype was associated with increased body mass index (BMI, kg/m(2)) (P-a = 0.03) among type 2 diabetic patients. The FOXC2 -512C > T polymorphism was a significant independent predictor of BMI (P = 0.001) in a multiple regression model including age, gender and affection status. We found no significant association with type 2 diabetes-related metabolic parameters but that the C-allele (P = 0.01) and C/C and C/T genotypes (P = 0.03) were significantly over-represented in type 2 diabetic males with a concomitant diagnosis of dysmetabolic syndrome. CONCLUSION: We conclude that FOXC2 is associated with obesity and metabolic deterioration but does not contribute to an increased risk for type 2 diabetes.}},
author = {{Nilsson, Emma A and Groop, Leif and Ridderstråle, Martin}},
issn = {{1476-5497}},
keywords = {{case-control association study; dysmetabolic syndrome; type 2 diabetes; noninsulin-dependent diabetes; forkhead transcription factor}},
language = {{eng}},
number = {{Dec 14}},
pages = {{268--274}},
publisher = {{Nature Publishing Group}},
series = {{International Journal of Obesity}},
title = {{Role of the FOXC2 -512C>T polymorphism in type 2 diabetes: possible association with the dysmetabolic syndrome.}},
url = {{https://lup.lub.lu.se/search/files/2983325/624276.pdf}},
doi = {{10.1038/sj.ijo.0802876}},
volume = {{29}},
year = {{2005}},
}