High ID2 protein expression correlates with a favourable prognosis in patients with primary breast cancer and reduces cellular invasiveness of breast cancer cells.
(2005) In International Journal of Cancer 115(3). p.403-411- Abstract
- ID proteins have been implicated in the regulation of cell proliferation and differentiation in various cell types during normal development as well as in the formation of cancer. Our aim was to delineate the expression of ID2 by immunohistochemistry in primary breast cancer in order to detect potential associations with cell cycle regulatory proteins and/or clinicopathologic parameters. We further overexpressed ID2 in a breast cancer cell line to elaborate potential effects on proliferation and invasiveness. We observed large variations in ID2 expression in primary breast cancer, and the protein was localised to both the nucleus and cytoplasm. Interestingly, a high cytoplasmic ID2 protein level correlated with a favourable prognosis.... (More)
- ID proteins have been implicated in the regulation of cell proliferation and differentiation in various cell types during normal development as well as in the formation of cancer. Our aim was to delineate the expression of ID2 by immunohistochemistry in primary breast cancer in order to detect potential associations with cell cycle regulatory proteins and/or clinicopathologic parameters. We further overexpressed ID2 in a breast cancer cell line to elaborate potential effects on proliferation and invasiveness. We observed large variations in ID2 expression in primary breast cancer, and the protein was localised to both the nucleus and cytoplasm. Interestingly, a high cytoplasmic ID2 protein level correlated with a favourable prognosis. Overexpressing ID2 in the MDA-MB-468 breast cancer cell line generated a marked cytoplasmic localisation of the protein and reduced the invasive capacity of cells. Modest enhancement of cell proliferation was further detected in ID2-overexpressing cells. In conclusion, ID2 protein expression varies substantially within primary breast tumours and high cytoplasmic levels of ID2 might reflect a less aggressive breast tumour phenotype. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/133909
- author
- Stighall, Maria LU ; Manetopoulos, Christina LU ; Axelson, Håkan LU and Landberg, Göran LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- breast cancer, invasion, proliferation, ID2
- in
- International Journal of Cancer
- volume
- 115
- issue
- 3
- pages
- 403 - 411
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000229025600010
- pmid:15688367
- scopus:18644374754
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.20875
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology (Malmö) (013031000), Molecular Medicine (013031200), Molecular Tumour Biology (013017540), Pathology, (Lund) (013030000)
- id
- 3160e475-7fa6-4150-ae19-c40cb2766efc (old id 133909)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15688367&dopt=Abstract
- date added to LUP
- 2016-04-01 11:37:54
- date last changed
- 2022-04-12 22:57:05
@article{3160e475-7fa6-4150-ae19-c40cb2766efc,
abstract = {{ID proteins have been implicated in the regulation of cell proliferation and differentiation in various cell types during normal development as well as in the formation of cancer. Our aim was to delineate the expression of ID2 by immunohistochemistry in primary breast cancer in order to detect potential associations with cell cycle regulatory proteins and/or clinicopathologic parameters. We further overexpressed ID2 in a breast cancer cell line to elaborate potential effects on proliferation and invasiveness. We observed large variations in ID2 expression in primary breast cancer, and the protein was localised to both the nucleus and cytoplasm. Interestingly, a high cytoplasmic ID2 protein level correlated with a favourable prognosis. Overexpressing ID2 in the MDA-MB-468 breast cancer cell line generated a marked cytoplasmic localisation of the protein and reduced the invasive capacity of cells. Modest enhancement of cell proliferation was further detected in ID2-overexpressing cells. In conclusion, ID2 protein expression varies substantially within primary breast tumours and high cytoplasmic levels of ID2 might reflect a less aggressive breast tumour phenotype.}},
author = {{Stighall, Maria and Manetopoulos, Christina and Axelson, Håkan and Landberg, Göran}},
issn = {{0020-7136}},
keywords = {{breast cancer; invasion; proliferation; ID2}},
language = {{eng}},
number = {{3}},
pages = {{403--411}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Cancer}},
title = {{High ID2 protein expression correlates with a favourable prognosis in patients with primary breast cancer and reduces cellular invasiveness of breast cancer cells.}},
url = {{http://dx.doi.org/10.1002/ijc.20875}},
doi = {{10.1002/ijc.20875}},
volume = {{115}},
year = {{2005}},
}