Tumefactive demyelinating disease treated with decompressive craniectomy.
(2009) In European Journal of Neurology 16. p.639-642- Abstract
- Background: Tumefactive demyelinating disease (TDD) is a rare primary demyelinating disease with diagnostic and therapeutic challenges. Methods and results: We report a 50-year old woman with TDD successfully treated with decompressive craniectomy and corticosteroids. The patient presented with seizures, subacute progressive hemispheric syndrome, and a tumourlike abnormality on MRI. Demyelinating disease was initially considered unlikely. Due to a rapidly evolving herniation syndrome hemicraniectomy was performed. Outcome was favourable with only very mild neurological deficits 6 weeks later. Conclusion: TDD should be considered as a differential diagnosis in tumour-like presentations, and appears to have distinctive neuroimaging features.... (More)
- Background: Tumefactive demyelinating disease (TDD) is a rare primary demyelinating disease with diagnostic and therapeutic challenges. Methods and results: We report a 50-year old woman with TDD successfully treated with decompressive craniectomy and corticosteroids. The patient presented with seizures, subacute progressive hemispheric syndrome, and a tumourlike abnormality on MRI. Demyelinating disease was initially considered unlikely. Due to a rapidly evolving herniation syndrome hemicraniectomy was performed. Outcome was favourable with only very mild neurological deficits 6 weeks later. Conclusion: TDD should be considered as a differential diagnosis in tumour-like presentations, and appears to have distinctive neuroimaging features. In the advent of treatement failure from high dose corticosteroids and plasmapheresis and development of severe mass effect, decompressive hemicraniectomy is an important treatment option. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1367482
- author
- Nilsson, Petra LU ; Larsson, Elna-Marie LU ; Kahlon, Babar LU ; Nordström, Carl-Henrik LU and Norrving, Bo LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Neurology
- volume
- 16
- pages
- 639 - 642
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000264881400023
- pmid:19309337
- scopus:64149125586
- pmid:19309337
- ISSN
- 1351-5101
- DOI
- 10.1111/j.1468-1331.2009.02547.x
- language
- English
- LU publication?
- yes
- id
- bc4d01b5-1b81-4fa1-96d6-daccb4fdff29 (old id 1367482)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19309337?dopt=Abstract
- date added to LUP
- 2016-04-04 07:38:29
- date last changed
- 2022-01-29 02:27:23
@article{bc4d01b5-1b81-4fa1-96d6-daccb4fdff29,
abstract = {{Background: Tumefactive demyelinating disease (TDD) is a rare primary demyelinating disease with diagnostic and therapeutic challenges. Methods and results: We report a 50-year old woman with TDD successfully treated with decompressive craniectomy and corticosteroids. The patient presented with seizures, subacute progressive hemispheric syndrome, and a tumourlike abnormality on MRI. Demyelinating disease was initially considered unlikely. Due to a rapidly evolving herniation syndrome hemicraniectomy was performed. Outcome was favourable with only very mild neurological deficits 6 weeks later. Conclusion: TDD should be considered as a differential diagnosis in tumour-like presentations, and appears to have distinctive neuroimaging features. In the advent of treatement failure from high dose corticosteroids and plasmapheresis and development of severe mass effect, decompressive hemicraniectomy is an important treatment option.}},
author = {{Nilsson, Petra and Larsson, Elna-Marie and Kahlon, Babar and Nordström, Carl-Henrik and Norrving, Bo}},
issn = {{1351-5101}},
language = {{eng}},
pages = {{639--642}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Neurology}},
title = {{Tumefactive demyelinating disease treated with decompressive craniectomy.}},
url = {{http://dx.doi.org/10.1111/j.1468-1331.2009.02547.x}},
doi = {{10.1111/j.1468-1331.2009.02547.x}},
volume = {{16}},
year = {{2009}},
}