An elemental diet fed, enteral or parenteral, does not support growth in young pigs with exocrine pancreatic insufficiency.
(2009) In Clinical Nutrition 28. p.325-330- Abstract
- BACKGROUND: & aims: Young individuals with exocrine pancreatic insufficiency (EPI) show growth reduction that can be reversed by dietary pancreatic enzyme supplementation. Here we investigated whether feeding an elemental diet could replace the growth-promoting effect of enzyme supplementation in EPI pigs. METHODS: Weaned pigs with intact pancreas (control) or pancreatic duct-ligated (EPI pigs) were given a commercial pig feed, a fat-enriched diet, or an elemental diet, intragastrically and intravenously, with or without porcine pancreatin (Creon((R))) supplementation for 1week. RESULTS: Control pigs, irrespective of receiving pig feed or an elemental diet, increased their body weight by 13.4-20.1%, while EPI pigs showed negligible... (More)
- BACKGROUND: & aims: Young individuals with exocrine pancreatic insufficiency (EPI) show growth reduction that can be reversed by dietary pancreatic enzyme supplementation. Here we investigated whether feeding an elemental diet could replace the growth-promoting effect of enzyme supplementation in EPI pigs. METHODS: Weaned pigs with intact pancreas (control) or pancreatic duct-ligated (EPI pigs) were given a commercial pig feed, a fat-enriched diet, or an elemental diet, intragastrically and intravenously, with or without porcine pancreatin (Creon((R))) supplementation for 1week. RESULTS: Control pigs, irrespective of receiving pig feed or an elemental diet, increased their body weight by 13.4-20.1%, while EPI pigs showed negligible weight gain. Giving a fat-enriched diet did not improve growth of the EPI pigs. However, if the EPI pigs were supplemented with pancreatin in combination with fat-enriched feed or the elemental diet, i.v., their body weight increased by 16.6 %and 8.5%, respectively. CONCLUSION: Control pigs maintained normal growth, independently of the diet being given in polymeric or elemental form, while EPI pigs showed impaired growth when receiving the same diets without enzyme supplementation. Pancreatic juice and enzyme preparations, in addition to their digestive properties, also appear to affect nutrient assimilation and anabolism in young individuals. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1367672
- author
- Rengman, Sofia LU ; Fedkiv, Olexandr LU ; Botermans, Jos ; Svendsen, Jörgen ; Weström, Björn LU and Pierzynowski, Stefan LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Nutrition
- volume
- 28
- pages
- 325 - 330
- publisher
- Elsevier
- external identifiers
-
- wos:000267620400018
- scopus:67349118728
- pmid:19297056
- ISSN
- 1532-1983
- DOI
- 10.1016/j.clnu.2009.02.010
- language
- English
- LU publication?
- yes
- id
- 362f662d-dd65-4ad1-8673-63ffaa2b5651 (old id 1367672)
- date added to LUP
- 2016-04-01 14:09:48
- date last changed
- 2022-01-27 23:06:47
@article{362f662d-dd65-4ad1-8673-63ffaa2b5651,
abstract = {{BACKGROUND: & aims: Young individuals with exocrine pancreatic insufficiency (EPI) show growth reduction that can be reversed by dietary pancreatic enzyme supplementation. Here we investigated whether feeding an elemental diet could replace the growth-promoting effect of enzyme supplementation in EPI pigs. METHODS: Weaned pigs with intact pancreas (control) or pancreatic duct-ligated (EPI pigs) were given a commercial pig feed, a fat-enriched diet, or an elemental diet, intragastrically and intravenously, with or without porcine pancreatin (Creon((R))) supplementation for 1week. RESULTS: Control pigs, irrespective of receiving pig feed or an elemental diet, increased their body weight by 13.4-20.1%, while EPI pigs showed negligible weight gain. Giving a fat-enriched diet did not improve growth of the EPI pigs. However, if the EPI pigs were supplemented with pancreatin in combination with fat-enriched feed or the elemental diet, i.v., their body weight increased by 16.6 %and 8.5%, respectively. CONCLUSION: Control pigs maintained normal growth, independently of the diet being given in polymeric or elemental form, while EPI pigs showed impaired growth when receiving the same diets without enzyme supplementation. Pancreatic juice and enzyme preparations, in addition to their digestive properties, also appear to affect nutrient assimilation and anabolism in young individuals.}},
author = {{Rengman, Sofia and Fedkiv, Olexandr and Botermans, Jos and Svendsen, Jörgen and Weström, Björn and Pierzynowski, Stefan}},
issn = {{1532-1983}},
language = {{eng}},
pages = {{325--330}},
publisher = {{Elsevier}},
series = {{Clinical Nutrition}},
title = {{An elemental diet fed, enteral or parenteral, does not support growth in young pigs with exocrine pancreatic insufficiency.}},
url = {{http://dx.doi.org/10.1016/j.clnu.2009.02.010}},
doi = {{10.1016/j.clnu.2009.02.010}},
volume = {{28}},
year = {{2009}},
}