Neuron specific enolase and S-100B as predictors of outcome after cardiac arrest and induced hypothermia.
(2009) In Resuscitation 80. p.784-789- Abstract
- AIM: To assess the prognostic value of repetitive serum samples of neuron specific enolase (NSE) and S-100B in cardiac arrest patients treated with hypothermia. METHODS: In a three-centre study, comatose patients after cardiac arrest were treated with hypothermia at 33 degrees C for 24h, regardless of cause or the initial rhythm. Serum samples were collected at 2, 24, 48 and 72h after the arrest and analysed for NSE and S-100B in a non-blinded way. The cerebral performance categories scale (CPC) was used as the outcome measure; a best CPC of 1-2 during 6 months was regarded as a good outcome, a best CPC of 3-5 a poor outcome. RESULTS: One centre was omitted in the NSE analysis due to missing 24 and 48h samples. Two partially overlapping... (More)
- AIM: To assess the prognostic value of repetitive serum samples of neuron specific enolase (NSE) and S-100B in cardiac arrest patients treated with hypothermia. METHODS: In a three-centre study, comatose patients after cardiac arrest were treated with hypothermia at 33 degrees C for 24h, regardless of cause or the initial rhythm. Serum samples were collected at 2, 24, 48 and 72h after the arrest and analysed for NSE and S-100B in a non-blinded way. The cerebral performance categories scale (CPC) was used as the outcome measure; a best CPC of 1-2 during 6 months was regarded as a good outcome, a best CPC of 3-5 a poor outcome. RESULTS: One centre was omitted in the NSE analysis due to missing 24 and 48h samples. Two partially overlapping groups were studied, the NSE group (n=102) and the S-100B group (n=107). NSE at 48h >28mug/l (specificity 100%, sensitivity 67%) and S-100B >0.51mug/l at 24h (specificity 96%, sensitivity 62%) correlated with a poor outcome, and so did a rise in NSE of >2mug/l between 24 and 48h (odds ratio 9.8, CI 3.5-27.7). A majority of missing samples (n=123) were from the 2h sampling time (n=56) due to referral from other hospitals or inter-hospital transfer. CONCLUSION: NSE was a better marker than S-100B for predicting outcome after cardiac arrest and induced hypothermia. NSE above 28mug/l at 48h and a rise in NSE of more than 2mug/l between 24 and 48h were markers for a poor outcome. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1412021
- author
- Rundgren, Malin LU ; Karlsson, Torbjörn LU ; Nielsen, Niklas LU ; Cronberg, Tobias LU ; Johnsson, Per and Friberg, Hans LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Resuscitation
- volume
- 80
- pages
- 784 - 789
- publisher
- Elsevier
- external identifiers
-
- wos:000267837100018
- pmid:19467754
- scopus:67349186978
- ISSN
- 1873-1570
- DOI
- 10.1016/j.resuscitation.2009.03.025
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Laboratory for Experimental Brain Research (013041000), Anaesthesiology and Intensive Care (013230022), Anaesthesiology and Intensive Care (Mö) (013241110)
- id
- 2e486b40-7293-41a9-a908-c37ea50613c5 (old id 1412021)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19467754?dopt=Abstract
- date added to LUP
- 2016-04-04 07:07:40
- date last changed
- 2024-01-12 00:16:57
@article{2e486b40-7293-41a9-a908-c37ea50613c5, abstract = {{AIM: To assess the prognostic value of repetitive serum samples of neuron specific enolase (NSE) and S-100B in cardiac arrest patients treated with hypothermia. METHODS: In a three-centre study, comatose patients after cardiac arrest were treated with hypothermia at 33 degrees C for 24h, regardless of cause or the initial rhythm. Serum samples were collected at 2, 24, 48 and 72h after the arrest and analysed for NSE and S-100B in a non-blinded way. The cerebral performance categories scale (CPC) was used as the outcome measure; a best CPC of 1-2 during 6 months was regarded as a good outcome, a best CPC of 3-5 a poor outcome. RESULTS: One centre was omitted in the NSE analysis due to missing 24 and 48h samples. Two partially overlapping groups were studied, the NSE group (n=102) and the S-100B group (n=107). NSE at 48h >28mug/l (specificity 100%, sensitivity 67%) and S-100B >0.51mug/l at 24h (specificity 96%, sensitivity 62%) correlated with a poor outcome, and so did a rise in NSE of >2mug/l between 24 and 48h (odds ratio 9.8, CI 3.5-27.7). A majority of missing samples (n=123) were from the 2h sampling time (n=56) due to referral from other hospitals or inter-hospital transfer. CONCLUSION: NSE was a better marker than S-100B for predicting outcome after cardiac arrest and induced hypothermia. NSE above 28mug/l at 48h and a rise in NSE of more than 2mug/l between 24 and 48h were markers for a poor outcome.}}, author = {{Rundgren, Malin and Karlsson, Torbjörn and Nielsen, Niklas and Cronberg, Tobias and Johnsson, Per and Friberg, Hans}}, issn = {{1873-1570}}, language = {{eng}}, pages = {{784--789}}, publisher = {{Elsevier}}, series = {{Resuscitation}}, title = {{Neuron specific enolase and S-100B as predictors of outcome after cardiac arrest and induced hypothermia.}}, url = {{http://dx.doi.org/10.1016/j.resuscitation.2009.03.025}}, doi = {{10.1016/j.resuscitation.2009.03.025}}, volume = {{80}}, year = {{2009}}, }