Survival in non-Hodgkin's lymphoma by histology and family history.
Ji, Jianguang LU
; Försti, Asta
LU
; Sundquist, Jan
LU
; Lenner, Per
and Hemminki, Kari
LU
(2009)
In Journal of Cancer Research and Clinical Oncology
135.
p.1711-1716
- Abstract
- PURPOSE: Although survival has been studied for various subtypes of non-Hodgkin's lymphoma (NHL), there have been few comprehensive studies to quantify the prognosis, including all specific histologies. The effect of family history on survival in NHL has not been examined. METHODS: We used the Swedish Family-Cancer Database to estimate hazard ratios in NHL by histology and family history. RESULTS: Using diffuse centroblastic lymphoma as reference (HR 1.0), patients with Waldenström's macroglobulinemia and hairy-cell leukemia had the best survival. Survival advantage was also noted among patients with lymphoplasmacytic lymphoma and different kinds of follicular lymphomas. For T-cell lymphoma, mycosis fungoides showed a favorable prognosis.... (More)
- PURPOSE: Although survival has been studied for various subtypes of non-Hodgkin's lymphoma (NHL), there have been few comprehensive studies to quantify the prognosis, including all specific histologies. The effect of family history on survival in NHL has not been examined. METHODS: We used the Swedish Family-Cancer Database to estimate hazard ratios in NHL by histology and family history. RESULTS: Using diffuse centroblastic lymphoma as reference (HR 1.0), patients with Waldenström's macroglobulinemia and hairy-cell leukemia had the best survival. Survival advantage was also noted among patients with lymphoplasmacytic lymphoma and different kinds of follicular lymphomas. For T-cell lymphoma, mycosis fungoides showed a favorable prognosis. As for survival by family history, a total of 98 familial cases were noted in our Database with a similar prognosis compared to sporadic cases in both parental and offspring generations. A non-significant familial concordance of either good or poor survival was noted among family members when probands' prognosis was stratified by survival time. CONCLUSIONS: Our results provide quantitative prognosis data for patients with NHL according to specific histologies. Patients with a familial NHL had a similar prognosis compared to patients with sporadic disease. The data suggest familial concordance in either good or poor survival among family members. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1434198
- author
- Ji, Jianguang
LU
; Försti, Asta
LU
; Sundquist, Jan
LU
; Lenner, Per
and Hemminki, Kari
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Cancer Research and Clinical Oncology
- volume
- 135
- pages
- 1711 - 1716
- publisher
- Springer
- external identifiers
-
- wos:000270176900009
- pmid:19533171
- scopus:70349760536
- pmid:19533171
- ISSN
- 1432-1335
- DOI
- 10.1007/s00432-009-0618-0
- language
- English
- LU publication?
- yes
- id
- 430ae27f-92e3-4eb3-8c5c-d80ff9597c9f (old id 1434198)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19533171?dopt=Abstract
- date added to LUP
- 2016-04-04 07:48:14
- date last changed
- 2022-01-29 02:38:11
@article{430ae27f-92e3-4eb3-8c5c-d80ff9597c9f,
abstract = {{PURPOSE: Although survival has been studied for various subtypes of non-Hodgkin's lymphoma (NHL), there have been few comprehensive studies to quantify the prognosis, including all specific histologies. The effect of family history on survival in NHL has not been examined. METHODS: We used the Swedish Family-Cancer Database to estimate hazard ratios in NHL by histology and family history. RESULTS: Using diffuse centroblastic lymphoma as reference (HR 1.0), patients with Waldenström's macroglobulinemia and hairy-cell leukemia had the best survival. Survival advantage was also noted among patients with lymphoplasmacytic lymphoma and different kinds of follicular lymphomas. For T-cell lymphoma, mycosis fungoides showed a favorable prognosis. As for survival by family history, a total of 98 familial cases were noted in our Database with a similar prognosis compared to sporadic cases in both parental and offspring generations. A non-significant familial concordance of either good or poor survival was noted among family members when probands' prognosis was stratified by survival time. CONCLUSIONS: Our results provide quantitative prognosis data for patients with NHL according to specific histologies. Patients with a familial NHL had a similar prognosis compared to patients with sporadic disease. The data suggest familial concordance in either good or poor survival among family members.}},
author = {{Ji, Jianguang and Försti, Asta and Sundquist, Jan and Lenner, Per and Hemminki, Kari}},
issn = {{1432-1335}},
language = {{eng}},
pages = {{1711--1716}},
publisher = {{Springer}},
series = {{Journal of Cancer Research and Clinical Oncology}},
title = {{Survival in non-Hodgkin's lymphoma by histology and family history.}},
url = {{http://dx.doi.org/10.1007/s00432-009-0618-0}},
doi = {{10.1007/s00432-009-0618-0}},
volume = {{135}},
year = {{2009}},
}