Prospective analysis of risk factors and distribution of venous thromboembolism in the population-based Malmö Thrombophilia Study (MATS).
(2009) In Thrombosis Research 124. p.663-666- Abstract
- BACKGROUND: Despite venous thromboembolism (VTE) being a major cause of morbidity and mortality, there is still limited information on its prevalence and incidence in the general population. OBJECTIVE: To evaluate risk factors, distribution and epidemiology of VTE in the Malmö area with 280 000 inhabitants. METHODS: Patients diagnosed with VTE at Malmö University Hospital in 1998-2006 were invited to a prospective population-based study. Blood sampling and a questionnaire study could be performed in 70% of patients. Remaining 30% were excluded due to language problems, dementia, other severe disease, or unwillingness to participate. RESULTS: During 1998-2006 1140 VTE patients (559 men [49%, age 62+/-16 years] and 581 women [51%, age... (More)
- BACKGROUND: Despite venous thromboembolism (VTE) being a major cause of morbidity and mortality, there is still limited information on its prevalence and incidence in the general population. OBJECTIVE: To evaluate risk factors, distribution and epidemiology of VTE in the Malmö area with 280 000 inhabitants. METHODS: Patients diagnosed with VTE at Malmö University Hospital in 1998-2006 were invited to a prospective population-based study. Blood sampling and a questionnaire study could be performed in 70% of patients. Remaining 30% were excluded due to language problems, dementia, other severe disease, or unwillingness to participate. RESULTS: During 1998-2006 1140 VTE patients (559 men [49%, age 62+/-16 years] and 581 women [51%, age 61+/-20 years]) were included. Deep venous thrombosis (DVT) occurred in 882 (77%), pulmonary embolism (PE) in 330 (29%), and both DVT and PE in 72 (6%). The most common acquired risk factors among VTE patients were hormone therapy (24% of female DVT patients and 19% of female PE patients), immobilisation (17% of DVT patients and 18% of PE patients), previous surgery (13% of DVT patients and 19% of PE patients), and concomitant malignant disease (12% of DVT patients and 11% of PE patients). A positive family history for VTE was obtained from 25% of DVT patients and 22% of PE patients. Yearly incidences of VTE, DVT and PE in Malmö were 66, 51, and 19/100.000, respectively. CONCLUSION: Hormone therapy, immobilisation, previous surgery and concomitant malignancy were the most common acquired risk factors among VTE patients in this population-based study. The VTE-incidence was lower than in earlier epidemiological studies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1434479
- author
- Isma, Nazim LU ; Svensson, Peter LU ; Gottsäter, Anders LU and Lindblad, Bengt LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Thrombosis Research
- volume
- 124
- pages
- 663 - 666
- publisher
- Elsevier
- external identifiers
-
- wos:000272857500006
- pmid:19497611
- scopus:70449532380
- ISSN
- 1879-2472
- DOI
- 10.1016/j.thromres.2009.04.022
- language
- English
- LU publication?
- yes
- id
- 3fbad433-088f-4001-b101-81399c29f820 (old id 1434479)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19497611?dopt=Abstract
- date added to LUP
- 2016-04-01 12:03:15
- date last changed
- 2022-04-21 01:41:56
@article{3fbad433-088f-4001-b101-81399c29f820, abstract = {{BACKGROUND: Despite venous thromboembolism (VTE) being a major cause of morbidity and mortality, there is still limited information on its prevalence and incidence in the general population. OBJECTIVE: To evaluate risk factors, distribution and epidemiology of VTE in the Malmö area with 280 000 inhabitants. METHODS: Patients diagnosed with VTE at Malmö University Hospital in 1998-2006 were invited to a prospective population-based study. Blood sampling and a questionnaire study could be performed in 70% of patients. Remaining 30% were excluded due to language problems, dementia, other severe disease, or unwillingness to participate. RESULTS: During 1998-2006 1140 VTE patients (559 men [49%, age 62+/-16 years] and 581 women [51%, age 61+/-20 years]) were included. Deep venous thrombosis (DVT) occurred in 882 (77%), pulmonary embolism (PE) in 330 (29%), and both DVT and PE in 72 (6%). The most common acquired risk factors among VTE patients were hormone therapy (24% of female DVT patients and 19% of female PE patients), immobilisation (17% of DVT patients and 18% of PE patients), previous surgery (13% of DVT patients and 19% of PE patients), and concomitant malignant disease (12% of DVT patients and 11% of PE patients). A positive family history for VTE was obtained from 25% of DVT patients and 22% of PE patients. Yearly incidences of VTE, DVT and PE in Malmö were 66, 51, and 19/100.000, respectively. CONCLUSION: Hormone therapy, immobilisation, previous surgery and concomitant malignancy were the most common acquired risk factors among VTE patients in this population-based study. The VTE-incidence was lower than in earlier epidemiological studies.}}, author = {{Isma, Nazim and Svensson, Peter and Gottsäter, Anders and Lindblad, Bengt}}, issn = {{1879-2472}}, language = {{eng}}, pages = {{663--666}}, publisher = {{Elsevier}}, series = {{Thrombosis Research}}, title = {{Prospective analysis of risk factors and distribution of venous thromboembolism in the population-based Malmö Thrombophilia Study (MATS).}}, url = {{http://dx.doi.org/10.1016/j.thromres.2009.04.022}}, doi = {{10.1016/j.thromres.2009.04.022}}, volume = {{124}}, year = {{2009}}, }