Longitudinal study of CSF biomarkers in patients with Alzheimer's disease.
Buchhave, Peder LU ; Blennow, Kaj ; Zetterberg, Henrik ; Stomrud, Erik LU
; Londos, Elisabet
LU
; Andreasen, Niels
; Minthon, Lennart
LU
and Hansson, Oskar
LU
(2009)
In PLoS ONE
4(7).
- Abstract
- BACKGROUND: The CSF biomarkers tau and Abeta42 can identify patients with AD, even during the preclinical stages. However, previous studies on longitudinal changes of tau and Abeta42 in individual patients with AD and elderly controls report somewhat inconsistent results. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the levels of tau and Abeta42 at baseline and after 1 year in 100 patients with AD. In a second cohort of 45 AD patients we measured the CSF biomarkers at baseline and after 2 years. Moreover, in 34 healthy elderly controls the CSF biomarkers were followed for 4 years. The baseline levels of tau were increased with >60% in AD patients compared to controls (p<0.001), while baseline Abeta42 levels were decreased with... (More)
- BACKGROUND: The CSF biomarkers tau and Abeta42 can identify patients with AD, even during the preclinical stages. However, previous studies on longitudinal changes of tau and Abeta42 in individual patients with AD and elderly controls report somewhat inconsistent results. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the levels of tau and Abeta42 at baseline and after 1 year in 100 patients with AD. In a second cohort of 45 AD patients we measured the CSF biomarkers at baseline and after 2 years. Moreover, in 34 healthy elderly controls the CSF biomarkers were followed for 4 years. The baseline levels of tau were increased with >60% in AD patients compared to controls (p<0.001), while baseline Abeta42 levels were decreased with >50% (p<0.001). In the AD group followed for 2 years, tau increased with 16% compared to the baseline levels (p<0.05). However, the levels of tau were stable over 4 years in the controls. The levels of Abeta42 did not change significantly over time in any of the groups. In the patients with AD, tau was moderately associated with worse cognitive performance already at baseline (p<0.05). CONCLUSIONS/SIGNIFICANCE: Tau and Abeta42 in CSF seem to reflect the underlying disease state in both early and late stages of AD. The slight increase in tau over time observed in the patients with AD is modest when compared to the relatively large difference in absolute tau levels between AD patients and controls. Therefore, these markers maintain their usefulness as state markers over time and might serve as surrogate markers for treatment efficacy in clinical trials. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1453018
- author
- Buchhave, Peder
LU
; Blennow, Kaj
; Zetterberg, Henrik
; Stomrud, Erik
LU
; Londos, Elisabet
LU
; Andreasen, Niels
; Minthon, Lennart
LU
and Hansson, Oskar
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 4
- issue
- 7
- article number
- e6294
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000268119500016
- pmid:19609443
- scopus:67650927663
- pmid:19609443
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0006294
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Memory Research Unit (013242610), Psychiatry/Primary Care/Public Health (013240500)
- id
- 05326096-2858-498a-a7ce-8752977269c1 (old id 1453018)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19609443?dopt=Abstract
- date added to LUP
- 2016-04-01 14:26:06
- date last changed
- 2023-11-13 07:26:18
@article{05326096-2858-498a-a7ce-8752977269c1,
abstract = {{BACKGROUND: The CSF biomarkers tau and Abeta42 can identify patients with AD, even during the preclinical stages. However, previous studies on longitudinal changes of tau and Abeta42 in individual patients with AD and elderly controls report somewhat inconsistent results. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the levels of tau and Abeta42 at baseline and after 1 year in 100 patients with AD. In a second cohort of 45 AD patients we measured the CSF biomarkers at baseline and after 2 years. Moreover, in 34 healthy elderly controls the CSF biomarkers were followed for 4 years. The baseline levels of tau were increased with >60% in AD patients compared to controls (p<0.001), while baseline Abeta42 levels were decreased with >50% (p<0.001). In the AD group followed for 2 years, tau increased with 16% compared to the baseline levels (p<0.05). However, the levels of tau were stable over 4 years in the controls. The levels of Abeta42 did not change significantly over time in any of the groups. In the patients with AD, tau was moderately associated with worse cognitive performance already at baseline (p<0.05). CONCLUSIONS/SIGNIFICANCE: Tau and Abeta42 in CSF seem to reflect the underlying disease state in both early and late stages of AD. The slight increase in tau over time observed in the patients with AD is modest when compared to the relatively large difference in absolute tau levels between AD patients and controls. Therefore, these markers maintain their usefulness as state markers over time and might serve as surrogate markers for treatment efficacy in clinical trials.}},
author = {{Buchhave, Peder and Blennow, Kaj and Zetterberg, Henrik and Stomrud, Erik and Londos, Elisabet and Andreasen, Niels and Minthon, Lennart and Hansson, Oskar}},
issn = {{1932-6203}},
language = {{eng}},
number = {{7}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{Longitudinal study of CSF biomarkers in patients with Alzheimer's disease.}},
url = {{http://dx.doi.org/10.1371/journal.pone.0006294}},
doi = {{10.1371/journal.pone.0006294}},
volume = {{4}},
year = {{2009}},
}