Serum calcium and tumour aggressiveness in breast cancer: a prospective study of 7847 women.
(2009) In European Journal of Cancer Prevention 18. p.354-360- Abstract
- Experimental, epidemiological and clinical studies suggest that calcium and/or its regulating hormones affect breast cancer risk. There has been no prospective cohort study investigating serum calcium levels and breast cancer aggressiveness, as determined by tumour histology and stage. Dichotomized prediagnostic serum calcium levels were investigated in relation to breast cancer aggressiveness as determined by grade (mitotic frequency, tubule formation, nuclear atypia) and stage (tumour size and axillary lymph node status). Cox's proportional hazards analysis and heterogeneity analysis were used to investigate the associations between low/high calcium and grade/stage in a prospective cohort study of 7847 women, out of whom 462 women were... (More)
- Experimental, epidemiological and clinical studies suggest that calcium and/or its regulating hormones affect breast cancer risk. There has been no prospective cohort study investigating serum calcium levels and breast cancer aggressiveness, as determined by tumour histology and stage. Dichotomized prediagnostic serum calcium levels were investigated in relation to breast cancer aggressiveness as determined by grade (mitotic frequency, tubule formation, nuclear atypia) and stage (tumour size and axillary lymph node status). Cox's proportional hazards analysis and heterogeneity analysis were used to investigate the associations between low/high calcium and grade/stage in a prospective cohort study of 7847 women, out of whom 462 women were diagnosed with incident breast cancer during a mean follow-up of 17.2 years. All analyses were stratified for body mass index and menopausal status. Prediagnostic serum calcium levels in premenopausal women were positively associated with increased tumour aggressiveness as determined by a higher risk of nodal metastasis; relative risk (RR) for calcium above median as compared with calcium below median was 1.88 with a 95% confidence interval (CI) of 1.04-3.38. In overweight women, prediagnostic serum calcium levels were also associated with tumour aggressiveness, as determined by both a higher risk of nodal metastasis [RR (95% CI) 1.69 (0.95-3.02)] and severe nuclear atypia [RR (95% CI) 2.06 (1.10-3.86)]. Results also indicate that, in overweight women, calcium is positively associated with worse grade as determined by tubule formation and mitotic frequency. In conclusion, prediagnostic serum calcium levels are positively associated with increased tumour aggressiveness in premenopausal and/or overweight women. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1453160
- author
- Almquist, Martin LU ; Anagnostaki, Lola ; Bondeson, Lennart LU ; Bondeson, Anne-Greth LU ; Borgquist, Signe LU ; Landberg, Göran LU ; Malina, Janne ; Malm, Johan LU and Manjer, Jonas LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Cancer Prevention
- volume
- 18
- pages
- 354 - 360
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000268869200003
- pmid:19593149
- scopus:69749110306
- pmid:19593149
- ISSN
- 1473-5709
- DOI
- 10.1097/CEJ.0b013e32832c386f
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Clinical Chemistry, Malmö (013016000), Surgery Research Unit (013242220), Hand Surgery Research Group (013241910), Pathology (Malmö) (013031000)
- id
- 1bad0aff-755a-49a0-80ce-4321d02eefbd (old id 1453160)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19593149?dopt=Abstract
- date added to LUP
- 2016-04-04 07:55:05
- date last changed
- 2022-04-23 08:50:37
@article{1bad0aff-755a-49a0-80ce-4321d02eefbd,
abstract = {{Experimental, epidemiological and clinical studies suggest that calcium and/or its regulating hormones affect breast cancer risk. There has been no prospective cohort study investigating serum calcium levels and breast cancer aggressiveness, as determined by tumour histology and stage. Dichotomized prediagnostic serum calcium levels were investigated in relation to breast cancer aggressiveness as determined by grade (mitotic frequency, tubule formation, nuclear atypia) and stage (tumour size and axillary lymph node status). Cox's proportional hazards analysis and heterogeneity analysis were used to investigate the associations between low/high calcium and grade/stage in a prospective cohort study of 7847 women, out of whom 462 women were diagnosed with incident breast cancer during a mean follow-up of 17.2 years. All analyses were stratified for body mass index and menopausal status. Prediagnostic serum calcium levels in premenopausal women were positively associated with increased tumour aggressiveness as determined by a higher risk of nodal metastasis; relative risk (RR) for calcium above median as compared with calcium below median was 1.88 with a 95% confidence interval (CI) of 1.04-3.38. In overweight women, prediagnostic serum calcium levels were also associated with tumour aggressiveness, as determined by both a higher risk of nodal metastasis [RR (95% CI) 1.69 (0.95-3.02)] and severe nuclear atypia [RR (95% CI) 2.06 (1.10-3.86)]. Results also indicate that, in overweight women, calcium is positively associated with worse grade as determined by tubule formation and mitotic frequency. In conclusion, prediagnostic serum calcium levels are positively associated with increased tumour aggressiveness in premenopausal and/or overweight women.}},
author = {{Almquist, Martin and Anagnostaki, Lola and Bondeson, Lennart and Bondeson, Anne-Greth and Borgquist, Signe and Landberg, Göran and Malina, Janne and Malm, Johan and Manjer, Jonas}},
issn = {{1473-5709}},
language = {{eng}},
pages = {{354--360}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{European Journal of Cancer Prevention}},
title = {{Serum calcium and tumour aggressiveness in breast cancer: a prospective study of 7847 women.}},
url = {{http://dx.doi.org/10.1097/CEJ.0b013e32832c386f}},
doi = {{10.1097/CEJ.0b013e32832c386f}},
volume = {{18}},
year = {{2009}},
}