Local Flip Angle Correction for Improved Volume T1-Quantification in Three-Dimensional dGEMRIC Using the Look-Locker Technique
(2009) In Journal of Magnetic Resonance Imaging 30(4). p.834-841- Abstract
- Purpose: To present an evaluation method for three-dimensional Look-Locker (3D-LL) based T1 quantification, calculating correct T1 values independent of local flip angle (FA) variations. The method was evaluated both in phantoms and in vivo in a delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) study with 33 subjects. Materials and Methods: T1 was measured with 3D-LL, using both local FA correction and a precalculated FA slice profile. and compared with standard constant FA correction, for all slices in phantoms and in both femur condyles in vivo. T1 measured using two-dimensional Inversion Recovery (2D-IR) was used as gold standard. Results: Due to the FA being slice dependent, the standard constant FA correction results in erroneous... (More)
- Purpose: To present an evaluation method for three-dimensional Look-Locker (3D-LL) based T1 quantification, calculating correct T1 values independent of local flip angle (FA) variations. The method was evaluated both in phantoms and in vivo in a delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) study with 33 subjects. Materials and Methods: T1 was measured with 3D-LL, using both local FA correction and a precalculated FA slice profile. and compared with standard constant FA correction, for all slices in phantoms and in both femur condyles in vivo. T1 measured using two-dimensional Inversion Recovery (2D-IR) was used as gold standard. Results: Due to the FA being slice dependent, the standard constant FA correction results in erroneous T1 (systematic error = 109.1 ms in vivo), especially in the outer slices. With local FA correction. the calculated T1 is excellent for all slices in phantoms (<5% deviation from 2D-IR). In vivo the performance is lower (systematic error = -57.5ms), probably due to imperfect inversion. With precalculated FA correction the performance is very good also in vivo (systematic error = 13.3 ms). Conclusion: With the precalculated FA correction method, the 3D-LL sequence is robust enough for in vivo dGEMRIC, even outside the centermost slices. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1489581
- author
- Siversson, Carl LU ; Tiderius, Carl Johan LU ; Dahlberg, Leif LU and Svensson, Jonas LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- dGEMRIC, B1 correction, flip angle correction, Look-Locker, T1 mapping, cartilage
- in
- Journal of Magnetic Resonance Imaging
- volume
- 30
- issue
- 4
- pages
- 834 - 841
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000270522900018
- scopus:70349664435
- pmid:19787729
- ISSN
- 1522-2586
- DOI
- 10.1002/jmri.21906
- language
- English
- LU publication?
- yes
- id
- 80c7c66d-9c29-4a60-9340-ea02d987d0d2 (old id 1489581)
- date added to LUP
- 2016-04-01 11:44:26
- date last changed
- 2024-01-07 18:36:13
@article{80c7c66d-9c29-4a60-9340-ea02d987d0d2, abstract = {{Purpose: To present an evaluation method for three-dimensional Look-Locker (3D-LL) based T1 quantification, calculating correct T1 values independent of local flip angle (FA) variations. The method was evaluated both in phantoms and in vivo in a delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) study with 33 subjects. Materials and Methods: T1 was measured with 3D-LL, using both local FA correction and a precalculated FA slice profile. and compared with standard constant FA correction, for all slices in phantoms and in both femur condyles in vivo. T1 measured using two-dimensional Inversion Recovery (2D-IR) was used as gold standard. Results: Due to the FA being slice dependent, the standard constant FA correction results in erroneous T1 (systematic error = 109.1 ms in vivo), especially in the outer slices. With local FA correction. the calculated T1 is excellent for all slices in phantoms (<5% deviation from 2D-IR). In vivo the performance is lower (systematic error = -57.5ms), probably due to imperfect inversion. With precalculated FA correction the performance is very good also in vivo (systematic error = 13.3 ms). Conclusion: With the precalculated FA correction method, the 3D-LL sequence is robust enough for in vivo dGEMRIC, even outside the centermost slices.}}, author = {{Siversson, Carl and Tiderius, Carl Johan and Dahlberg, Leif and Svensson, Jonas}}, issn = {{1522-2586}}, keywords = {{dGEMRIC; B1 correction; flip angle correction; Look-Locker; T1 mapping; cartilage}}, language = {{eng}}, number = {{4}}, pages = {{834--841}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Journal of Magnetic Resonance Imaging}}, title = {{Local Flip Angle Correction for Improved Volume T1-Quantification in Three-Dimensional dGEMRIC Using the Look-Locker Technique}}, url = {{http://dx.doi.org/10.1002/jmri.21906}}, doi = {{10.1002/jmri.21906}}, volume = {{30}}, year = {{2009}}, }