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Adherence to a Mediterranean diet and risk of gastric adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study

Buckland, Genevieve ; Agudo, Antonio ; Lujan, Leila ; Jakszyn, Paula ; Bueno-de-Mesquita, H. Bas ; Palli, Domenico ; Boeing, Heiner ; Carneiro, Fatima ; Krogh, Vittorio and Sacerdote, Carlotta , et al. (2010) In American Journal of Clinical Nutrition 91(2). p.381-390
Abstract
Background: The Mediterranean dietary pattern is believed to protect against cancer, although evidence from cohort studies that have examined particular cancer sites is limited. Objective: We aimed to explore the association between adherence to a relative Mediterranean diet (rMED) and incident gastric adenocarcinoma (GC) within the European Prospective Investigation into Cancer and Nutrition study. Design: The study included 485,044 subjects (144,577 men) aged 35-70 y from 10 European countries. At recruitment, dietary and lifestyle information was collected. An 18-unit rMED score, incorporating 9 key components of the Mediterranean diet, was used to estimate rMED adherence. The association between rMED and GC with respect to anatomic... (More)
Background: The Mediterranean dietary pattern is believed to protect against cancer, although evidence from cohort studies that have examined particular cancer sites is limited. Objective: We aimed to explore the association between adherence to a relative Mediterranean diet (rMED) and incident gastric adenocarcinoma (GC) within the European Prospective Investigation into Cancer and Nutrition study. Design: The study included 485,044 subjects (144,577 men) aged 35-70 y from 10 European countries. At recruitment, dietary and lifestyle information was collected. An 18-unit rMED score, incorporating 9 key components of the Mediterranean diet, was used to estimate rMED adherence. The association between rMED and GC with respect to anatomic location (cardia and noncardia) and histologic types (diffuse and intestinal) was investigated. A calibration study in a subsample was used to control for dietary measurement error. Results: After a mean follow-up of 8.9 y, 449 validated incident GC cases were identified and used in the analysis. After stratification by center and age and adjustment for recognized cancer risk factors, high compared with low rMED adherence was associated with a significant reduction in GC risk (hazard ratio: 0.67; 95% CI: 0.47, 0.94). A 1-unit increase in the rMED score was associated with a decreased risk of GC of 5% (95% CI: 0.91, 0.99). There was no evidence of heterogeneity between different anatomic locations or histologic types. The calibrated results showed similar trends (overall hazard ratio for GC: 0.93; 95% CI: 0.89, 0.99). Conclusion: Greater adherence to an rMED is associated with a significant reduction in the risk of incident GC. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Clinical Nutrition
volume
91
issue
2
pages
381 - 390
publisher
Elsevier
external identifiers
  • wos:000273947500013
  • scopus:75649134612
  • pmid:20007304
ISSN
1938-3207
DOI
10.3945/ajcn.2009.28209
language
English
LU publication?
yes
id
d6b07638-6b46-408d-a084-8f1537b766b0 (old id 1547075)
date added to LUP
2016-04-01 13:42:12
date last changed
2025-04-04 14:25:48
@article{d6b07638-6b46-408d-a084-8f1537b766b0,
  abstract     = {{Background: The Mediterranean dietary pattern is believed to protect against cancer, although evidence from cohort studies that have examined particular cancer sites is limited. Objective: We aimed to explore the association between adherence to a relative Mediterranean diet (rMED) and incident gastric adenocarcinoma (GC) within the European Prospective Investigation into Cancer and Nutrition study. Design: The study included 485,044 subjects (144,577 men) aged 35-70 y from 10 European countries. At recruitment, dietary and lifestyle information was collected. An 18-unit rMED score, incorporating 9 key components of the Mediterranean diet, was used to estimate rMED adherence. The association between rMED and GC with respect to anatomic location (cardia and noncardia) and histologic types (diffuse and intestinal) was investigated. A calibration study in a subsample was used to control for dietary measurement error. Results: After a mean follow-up of 8.9 y, 449 validated incident GC cases were identified and used in the analysis. After stratification by center and age and adjustment for recognized cancer risk factors, high compared with low rMED adherence was associated with a significant reduction in GC risk (hazard ratio: 0.67; 95% CI: 0.47, 0.94). A 1-unit increase in the rMED score was associated with a decreased risk of GC of 5% (95% CI: 0.91, 0.99). There was no evidence of heterogeneity between different anatomic locations or histologic types. The calibrated results showed similar trends (overall hazard ratio for GC: 0.93; 95% CI: 0.89, 0.99). Conclusion: Greater adherence to an rMED is associated with a significant reduction in the risk of incident GC.}},
  author       = {{Buckland, Genevieve and Agudo, Antonio and Lujan, Leila and Jakszyn, Paula and Bueno-de-Mesquita, H. Bas and Palli, Domenico and Boeing, Heiner and Carneiro, Fatima and Krogh, Vittorio and Sacerdote, Carlotta and Tumino, Rosario and Panico, Salvatore and Nesi, Gabriella and Manjer, Jonas and Regnér, Sara and Johansson, Ingegerd and Stenling, Roger and Sanchez, Maria-Jose and Dorronsoro, Miren and Barricarte, Aurelio and Navarro, Carmen and Ramon Quiros, J. and Allen, Naomi E. and Key, Timothy J. and Bingham, Sheila and Kaaks, Rudolf and Overvad, Kim and Jensen, Majken and Olsen, Anja and Tjonneland, Anne and Peeters, Petra H. M. and Numans, Mattijs E. and Ocke, Marga C. and Clavel-Chapelon, Francoise and Morois, Sophie and Boutron-Ruault, Marie-Christine and Trichopoulou, Antonia and Lagiou, Pagona and Trichopoulos, Dimitrios and Lund, Eiliv and Couto, Elisabeth and Boffeta, Paolo and Jenab, Mazda and Riboli, Elio and Romaguera, Dora and Mouw, Traci and Gonzalez, Carlos A.}},
  issn         = {{1938-3207}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{381--390}},
  publisher    = {{Elsevier}},
  series       = {{American Journal of Clinical Nutrition}},
  title        = {{Adherence to a Mediterranean diet and risk of gastric adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study}},
  url          = {{http://dx.doi.org/10.3945/ajcn.2009.28209}},
  doi          = {{10.3945/ajcn.2009.28209}},
  volume       = {{91}},
  year         = {{2010}},
}