Decreased neutrophil function in newly diagnosed multiple myeloma patients is restored with lenalidomide therapy
(2024) In European Journal of Haematology- Abstract
OBJECTIVES: Bacterial infections are common and a major cause of morbidity and mortality in multiple myeloma (MM). We have investigated the function of polymorphonuclear leukocyte (PMN), the immune system's first line of defense against bacteria, in peripheral blood (PB) and bone marrow (BM) samples from patients with newly diagnosed MM (NDMM), smoldering MM (SMM), monoclonal gammopathy of undetermined significance (MGUS) and healthy controls.
METHODS: Phagocytosis and oxidative burst in PMN cells from patients and healthy donors were investigated using PhagoTest and PhagoBurst assay.
RESULTS: PMN from NDMM, SMM, and MGUS patients had reduced phagocytosis and oxidative burst ability compared with healthy controls. The... (More)
OBJECTIVES: Bacterial infections are common and a major cause of morbidity and mortality in multiple myeloma (MM). We have investigated the function of polymorphonuclear leukocyte (PMN), the immune system's first line of defense against bacteria, in peripheral blood (PB) and bone marrow (BM) samples from patients with newly diagnosed MM (NDMM), smoldering MM (SMM), monoclonal gammopathy of undetermined significance (MGUS) and healthy controls.
METHODS: Phagocytosis and oxidative burst in PMN cells from patients and healthy donors were investigated using PhagoTest and PhagoBurst assay.
RESULTS: PMN from NDMM, SMM, and MGUS patients had reduced phagocytosis and oxidative burst ability compared with healthy controls. The dysfunction was most prominent in BM samples from MM, SMM, and MGUS patients. Importantly the reduced phagocytosis in MM patients was restored in patients on lenalidomide therapy. Consistently the ability of Escherichia coli stimulated oxidative burst in BM was reduced for the MM, SMM, and MGUS cohort in contrast to the healthy controls and the patients on lenalidomide treatment.
CONCLUSION: Our results show that MM patients have neutrophil dysfunction that could contribute to susceptibility for bacterial infections and that lenalidomide therapy was associated with restored PMN function.
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- author
- Askman, Sandra LU ; Westerlund, Julia LU ; Pettersson, Åsa LU ; Hellmark, Thomas LU ; Johansson, Åsa LU ; Wichert, Stina LU and Hansson, Markus LU
- organization
- publishing date
- 2024-03-29
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- European Journal of Haematology
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85189635410
- pmid:38553844
- ISSN
- 1600-0609
- DOI
- 10.1111/ejh.14200
- language
- English
- LU publication?
- yes
- additional info
- © 2024 The Authors. European Journal of Haematology published by John Wiley & Sons Ltd.
- id
- 15cd5b63-ab82-4ef8-9dc1-70a5e5b945b7
- date added to LUP
- 2024-04-04 22:18:36
- date last changed
- 2024-05-07 16:10:17
@article{15cd5b63-ab82-4ef8-9dc1-70a5e5b945b7, abstract = {{<p>OBJECTIVES: Bacterial infections are common and a major cause of morbidity and mortality in multiple myeloma (MM). We have investigated the function of polymorphonuclear leukocyte (PMN), the immune system's first line of defense against bacteria, in peripheral blood (PB) and bone marrow (BM) samples from patients with newly diagnosed MM (NDMM), smoldering MM (SMM), monoclonal gammopathy of undetermined significance (MGUS) and healthy controls.</p><p>METHODS: Phagocytosis and oxidative burst in PMN cells from patients and healthy donors were investigated using PhagoTest and PhagoBurst assay.</p><p>RESULTS: PMN from NDMM, SMM, and MGUS patients had reduced phagocytosis and oxidative burst ability compared with healthy controls. The dysfunction was most prominent in BM samples from MM, SMM, and MGUS patients. Importantly the reduced phagocytosis in MM patients was restored in patients on lenalidomide therapy. Consistently the ability of Escherichia coli stimulated oxidative burst in BM was reduced for the MM, SMM, and MGUS cohort in contrast to the healthy controls and the patients on lenalidomide treatment.</p><p>CONCLUSION: Our results show that MM patients have neutrophil dysfunction that could contribute to susceptibility for bacterial infections and that lenalidomide therapy was associated with restored PMN function.</p>}}, author = {{Askman, Sandra and Westerlund, Julia and Pettersson, Åsa and Hellmark, Thomas and Johansson, Åsa and Wichert, Stina and Hansson, Markus}}, issn = {{1600-0609}}, language = {{eng}}, month = {{03}}, publisher = {{Wiley-Blackwell}}, series = {{European Journal of Haematology}}, title = {{Decreased neutrophil function in newly diagnosed multiple myeloma patients is restored with lenalidomide therapy}}, url = {{http://dx.doi.org/10.1111/ejh.14200}}, doi = {{10.1111/ejh.14200}}, year = {{2024}}, }