Evaluation of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis
Salim, Saman LU ; Ekberg, Olle LU ; Elf, Johan LU ; Zarrouk, Moncef LU ; Gottsäter, Anders LU and Acosta, Stefan LU
(2019)
In Phlebology
34(3).
p.171-178
- Abstract
Background/aim: Mesenteric venous thrombosis is a rare lethal disease. The main aim of the present study was to evaluate clinical efficacy and safety of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis patients. Methods: Retrospective study of 102 mesenteric venous thrombosis patients treated between 2004 and 2017 at a center with a conservative medical first approach. Median clinical follow-up was 4 years. Results: Computed tomography showed successful recanalization of thrombosis in 71% of patients on vitamin K antagonists and 69% of patients on direct oral anticoagulants (p = 0.88). Overall major and esophageal variceal bleeding rate was 14.7% and 2.9%, respectively. No difference in major bleeding... (More)
Background/aim: Mesenteric venous thrombosis is a rare lethal disease. The main aim of the present study was to evaluate clinical efficacy and safety of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis patients. Methods: Retrospective study of 102 mesenteric venous thrombosis patients treated between 2004 and 2017 at a center with a conservative medical first approach. Median clinical follow-up was 4 years. Results: Computed tomography showed successful recanalization of thrombosis in 71% of patients on vitamin K antagonists and 69% of patients on direct oral anticoagulants (p = 0.88). Overall major and esophageal variceal bleeding rate was 14.7% and 2.9%, respectively. No difference in major bleeding (p = 0.54) was found between vitamin K antagonists and direct oral anticoagulants. No mesenteric venous thrombosis recurrence occurred during follow-up, and one venous thromboembolism occurred after cessation of anticoagulation. Conclusion: Anticoagulation with direct oral anticoagulants and vitamin K antagonists was efficient in patients with mesenteric venous thrombosis. Bleeding complications was a concern during treatment in both groups.
(Less)
- author
- Salim, Saman
LU
; Ekberg, Olle
LU
; Elf, Johan
LU
; Zarrouk, Moncef
LU
; Gottsäter, Anders
LU
and Acosta, Stefan
LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- anticoagulation, computed tomography, direct oral anticoagulants, efficacy, Mesenteric venous thrombosis, recanalization, safety
- in
- Phlebology
- volume
- 34
- issue
- 3
- pages
- 171 - 178
- publisher
- Springer
- external identifiers
-
- pmid:29848218
- scopus:85047928818
- ISSN
- 0268-3555
- DOI
- 10.1177/0268355518779517
- language
- English
- LU publication?
- yes
- id
- 15ec7fd4-f3e5-4035-a34e-0f6d0a63b8b0
- date added to LUP
- 2018-06-14 16:08:46
- date last changed
- 2025-10-15 22:27:17
@article{15ec7fd4-f3e5-4035-a34e-0f6d0a63b8b0,
abstract = {{<p>Background/aim: Mesenteric venous thrombosis is a rare lethal disease. The main aim of the present study was to evaluate clinical efficacy and safety of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis patients. Methods: Retrospective study of 102 mesenteric venous thrombosis patients treated between 2004 and 2017 at a center with a conservative medical first approach. Median clinical follow-up was 4 years. Results: Computed tomography showed successful recanalization of thrombosis in 71% of patients on vitamin K antagonists and 69% of patients on direct oral anticoagulants (p = 0.88). Overall major and esophageal variceal bleeding rate was 14.7% and 2.9%, respectively. No difference in major bleeding (p = 0.54) was found between vitamin K antagonists and direct oral anticoagulants. No mesenteric venous thrombosis recurrence occurred during follow-up, and one venous thromboembolism occurred after cessation of anticoagulation. Conclusion: Anticoagulation with direct oral anticoagulants and vitamin K antagonists was efficient in patients with mesenteric venous thrombosis. Bleeding complications was a concern during treatment in both groups.</p>}},
author = {{Salim, Saman and Ekberg, Olle and Elf, Johan and Zarrouk, Moncef and Gottsäter, Anders and Acosta, Stefan}},
issn = {{0268-3555}},
keywords = {{anticoagulation; computed tomography; direct oral anticoagulants; efficacy; Mesenteric venous thrombosis; recanalization; safety}},
language = {{eng}},
number = {{3}},
pages = {{171--178}},
publisher = {{Springer}},
series = {{Phlebology}},
title = {{Evaluation of direct oral anticoagulants and vitamin K antagonists in mesenteric venous thrombosis}},
url = {{http://dx.doi.org/10.1177/0268355518779517}},
doi = {{10.1177/0268355518779517}},
volume = {{34}},
year = {{2019}},
}