Estimation of the Age-Dependent Decline of Glomerular Filtration Rate from Formulas Based on Creatinine and Cystatin C in the General Elderly Population.
(2011) In Nephron Clinical Practice 117(1). p.40-50- Abstract
- Background/Aims: To evaluate the performance of estimation formulas for glomerular filtration rate (GFR) based on creatinine and cystatin C in elderly. Methods: This study includes 2,931 men and women comprising nine age cohorts (60-93 years) from a longitudinal population-based project in Sweden. The participants were divided into four age groups. GFR was estimated from four formulas: the Modification of Diet in Renal Disease (MDRD), CKD-EPI and Cockroft-Gault (CG) based on creatinine and one based on cystatin C (eGFR-CysC). CG was also adjusted for body surface area (BSA) to CG/BSA. Results: CG, CG/BSA and eGFR-CysC yielded significantly lower GFR values compared to MDRD and CKD-EPI in the oldest persons (>80 years). A low GFR (<30... (More)
- Background/Aims: To evaluate the performance of estimation formulas for glomerular filtration rate (GFR) based on creatinine and cystatin C in elderly. Methods: This study includes 2,931 men and women comprising nine age cohorts (60-93 years) from a longitudinal population-based project in Sweden. The participants were divided into four age groups. GFR was estimated from four formulas: the Modification of Diet in Renal Disease (MDRD), CKD-EPI and Cockroft-Gault (CG) based on creatinine and one based on cystatin C (eGFR-CysC). CG was also adjusted for body surface area (BSA) to CG/BSA. Results: CG, CG/BSA and eGFR-CysC yielded significantly lower GFR values compared to MDRD and CKD-EPI in the oldest persons (>80 years). A low GFR (<30 ml/min/1.73 m(2)) was demonstrated with MDRD in 3.3% (80-89 years) and in 6.3% (>90 years). With CG/BSA it was 8.0% (80-89 years) and 27.2% (>90 years), and with eGFR-CysC it was 12.1% (80-89 years) and 27% (>90 years), respectively. The individual formulas showed different eGFR in the four age cohorts and also different slopes by increasing age. CG/BSA and eGFR-CysC both show steeper declines than MDRD and CKD-EPI. Conclusion: Age-associated decline of renal function is common in elderly and increases immensely after the age of 80 years. More than 25% of the oldest demonstrate eGFR <30 ml/min/1.73 m(2). CG and eGFR-CysC yielded the highest prevalence of decline and MDRD the lowest. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1665515
- author
- Christensson, Anders LU and Elmståhl, Sölve LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nephron Clinical Practice
- volume
- 117
- issue
- 1
- pages
- 40 - 50
- publisher
- Karger
- external identifiers
-
- wos:000280683300009
- pmid:20689324
- scopus:77955122884
- pmid:20689324
- ISSN
- 1660-2110
- DOI
- 10.1159/000319646
- language
- English
- LU publication?
- yes
- id
- 91770abb-ca46-4203-a4c1-0c02a415a601 (old id 1665515)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20689324?dopt=Abstract
- date added to LUP
- 2016-04-04 08:39:29
- date last changed
- 2022-02-06 00:16:00
@article{91770abb-ca46-4203-a4c1-0c02a415a601,
abstract = {{Background/Aims: To evaluate the performance of estimation formulas for glomerular filtration rate (GFR) based on creatinine and cystatin C in elderly. Methods: This study includes 2,931 men and women comprising nine age cohorts (60-93 years) from a longitudinal population-based project in Sweden. The participants were divided into four age groups. GFR was estimated from four formulas: the Modification of Diet in Renal Disease (MDRD), CKD-EPI and Cockroft-Gault (CG) based on creatinine and one based on cystatin C (eGFR-CysC). CG was also adjusted for body surface area (BSA) to CG/BSA. Results: CG, CG/BSA and eGFR-CysC yielded significantly lower GFR values compared to MDRD and CKD-EPI in the oldest persons (>80 years). A low GFR (<30 ml/min/1.73 m(2)) was demonstrated with MDRD in 3.3% (80-89 years) and in 6.3% (>90 years). With CG/BSA it was 8.0% (80-89 years) and 27.2% (>90 years), and with eGFR-CysC it was 12.1% (80-89 years) and 27% (>90 years), respectively. The individual formulas showed different eGFR in the four age cohorts and also different slopes by increasing age. CG/BSA and eGFR-CysC both show steeper declines than MDRD and CKD-EPI. Conclusion: Age-associated decline of renal function is common in elderly and increases immensely after the age of 80 years. More than 25% of the oldest demonstrate eGFR <30 ml/min/1.73 m(2). CG and eGFR-CysC yielded the highest prevalence of decline and MDRD the lowest.}},
author = {{Christensson, Anders and Elmståhl, Sölve}},
issn = {{1660-2110}},
language = {{eng}},
number = {{1}},
pages = {{40--50}},
publisher = {{Karger}},
series = {{Nephron Clinical Practice}},
title = {{Estimation of the Age-Dependent Decline of Glomerular Filtration Rate from Formulas Based on Creatinine and Cystatin C in the General Elderly Population.}},
url = {{http://dx.doi.org/10.1159/000319646}},
doi = {{10.1159/000319646}},
volume = {{117}},
year = {{2011}},
}