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Hypoxia inducible factor-2alpha in cancer.

Löfstedt, Tobias LU ; Fredlund, Erik LU ; Holmquist Mengelbier, Linda LU ; Pietras, Alexander LU ; Ovenberger, Marie LU ; Poellinger, Lorenz and Påhlman, Sven LU (2007) In Cell Cycle 6(8). p.919-926
Abstract
Poorly oxygenated ( hypoxic) tumors are frequently more aggressive compared to corresponding tumors that are better oxygenated. Adaptation to hypoxia is primarily mediated by two closely related hypoxia inducible transcription factor complexes, HIF-1 and HIF-2, which become stabilized and activated at low oxygen levels. Whether HIF-1 and HIF-2 have different roles in tumorigenesis is an open question and an issue we discuss. With focus on HIF-2, we summarize reported phenotypical changes of HIF genetic models and HIF expression patterns during normal development, in adult non - malignant tissues and in tumors. We further address the much - discussed subject of target gene preferences between HIF-1 and HIF-2, given that both transcription... (More)
Poorly oxygenated ( hypoxic) tumors are frequently more aggressive compared to corresponding tumors that are better oxygenated. Adaptation to hypoxia is primarily mediated by two closely related hypoxia inducible transcription factor complexes, HIF-1 and HIF-2, which become stabilized and activated at low oxygen levels. Whether HIF-1 and HIF-2 have different roles in tumorigenesis is an open question and an issue we discuss. With focus on HIF-2, we summarize reported phenotypical changes of HIF genetic models and HIF expression patterns during normal development, in adult non - malignant tissues and in tumors. We further address the much - discussed subject of target gene preferences between HIF-1 and HIF-2, given that both transcription factors bind to the same DNA motif. Finally, we also discuss the observations that the oxygen - sensitive HIF-2 alpha subunit is accumulated and active under non - hypoxic conditions as exemplified by HIF-2 alpha expressing tumor macrophages and neuroblastoma cells located in seemingly well - vascularized tumor regions and how this phenomenon is related to tumor aggressiveness. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
target genes, neuroblastoma, regulation, development, adaptation, hypoxia, cancer, hypoxia-inducible factor
in
Cell Cycle
volume
6
issue
8
pages
919 - 926
publisher
Landes Bioscience
external identifiers
  • wos:000245948300010
  • scopus:34247477207
ISSN
1551-4005
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Molecular Medicine (013031200)
id
4c854fdb-f32f-4633-b235-9fcb54aca5e2 (old id 167829)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17404509&dopt=Abstract
http://www.landesbioscience.com/journals/cc/article/4133
date added to LUP
2016-04-01 12:04:02
date last changed
2022-04-21 01:58:20
@article{4c854fdb-f32f-4633-b235-9fcb54aca5e2,
  abstract     = {{Poorly oxygenated ( hypoxic) tumors are frequently more aggressive compared to corresponding tumors that are better oxygenated. Adaptation to hypoxia is primarily mediated by two closely related hypoxia inducible transcription factor complexes, HIF-1 and HIF-2, which become stabilized and activated at low oxygen levels. Whether HIF-1 and HIF-2 have different roles in tumorigenesis is an open question and an issue we discuss. With focus on HIF-2, we summarize reported phenotypical changes of HIF genetic models and HIF expression patterns during normal development, in adult non - malignant tissues and in tumors. We further address the much - discussed subject of target gene preferences between HIF-1 and HIF-2, given that both transcription factors bind to the same DNA motif. Finally, we also discuss the observations that the oxygen - sensitive HIF-2 alpha subunit is accumulated and active under non - hypoxic conditions as exemplified by HIF-2 alpha expressing tumor macrophages and neuroblastoma cells located in seemingly well - vascularized tumor regions and how this phenomenon is related to tumor aggressiveness.}},
  author       = {{Löfstedt, Tobias and Fredlund, Erik and Holmquist Mengelbier, Linda and Pietras, Alexander and Ovenberger, Marie and Poellinger, Lorenz and Påhlman, Sven}},
  issn         = {{1551-4005}},
  keywords     = {{target genes; neuroblastoma; regulation; development; adaptation; hypoxia; cancer; hypoxia-inducible factor}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{919--926}},
  publisher    = {{Landes Bioscience}},
  series       = {{Cell Cycle}},
  title        = {{Hypoxia inducible factor-2alpha in cancer.}},
  url          = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17404509&dopt=Abstract}},
  volume       = {{6}},
  year         = {{2007}},
}