Prevalence of antibodies against Kaposi's sarcoma associated herpes virus (KSHV) complement inhibitory protein (KCP) in KSHV-related diseases and their correlation with clinical parameters.
Okroj, Marcin LU ; Tedeschi, Rosamaria ; Mancuso, Roberta ; Brambilla, Lucia ; Tourlaki, Athanasia ; Dillner, Joakim LU and Blom, Anna LU
(2011)
In Vaccine
29.
p.1129-1134
- Abstract
- Kaposi's sarcoma-associated herpes virus (KSHV) encodes its own inhibitor of the complement system, designated KSHV complement control protein (KCP). Previously, we detected anti-KCP antibodies in a small group of 22 patients suffering from Kaposi's sarcoma (KS) and KSHV-related lymphoproliferative diseases (Vaccine, 25:8102-9). Anti-KCP antibodies were more prevalent in individuals suffering from KSHV-related lymphomas than KS and also in those with high titer of antibodies against lytic KSHV antigens. Herein we analyze anti-KCP antibodies in 175 individuals originating from three different groups from northern Sweden or Italy, which included patients suffering from classical or HIV-associated KS, Multicentric Castleman's Disease,... (More)
- Kaposi's sarcoma-associated herpes virus (KSHV) encodes its own inhibitor of the complement system, designated KSHV complement control protein (KCP). Previously, we detected anti-KCP antibodies in a small group of 22 patients suffering from Kaposi's sarcoma (KS) and KSHV-related lymphoproliferative diseases (Vaccine, 25:8102-9). Anti-KCP antibodies were more prevalent in individuals suffering from KSHV-related lymphomas than KS and also in those with high titer of antibodies against lytic KSHV antigens. Herein we analyze anti-KCP antibodies in 175 individuals originating from three different groups from northern Sweden or Italy, which included patients suffering from classical or HIV-associated KS, Multicentric Castleman's Disease, KSHV-associated solid lymphoma, pleural effusion lymphoma and healthy individuals with detectable KSHV immune response. Our current study confirmed previous observations concerning antibody prevalence but we also analyzed correlations between anti-KCP antibodies and classical KS evolution, clinical stage and viral load in body fluids. Furthermore, we show that patient's anti-KCP antibodies are able to decrease the ability of KCP to inhibit complement. This fact combined with results of statistical analysis suggests that KCP inactivation by specific antibodies may influence progression of classical KS. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1756686
- author
- Okroj, Marcin
LU
; Tedeschi, Rosamaria
; Mancuso, Roberta
; Brambilla, Lucia
; Tourlaki, Athanasia
; Dillner, Joakim
LU
and Blom, Anna
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Vaccine
- volume
- 29
- pages
- 1129 - 1134
- publisher
- Elsevier
- external identifiers
-
- wos:000287339800004
- pmid:21134448
- scopus:78751567997
- pmid:21134448
- ISSN
- 1873-2518
- DOI
- 10.1016/j.vaccine.2010.11.070
- language
- English
- LU publication?
- yes
- id
- 859f45af-d3bc-4f51-8ee3-dfa69204aac0 (old id 1756686)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21134448?dopt=Abstract
- date added to LUP
- 2016-04-01 10:14:56
- date last changed
- 2022-01-25 21:22:26
@article{859f45af-d3bc-4f51-8ee3-dfa69204aac0,
abstract = {{Kaposi's sarcoma-associated herpes virus (KSHV) encodes its own inhibitor of the complement system, designated KSHV complement control protein (KCP). Previously, we detected anti-KCP antibodies in a small group of 22 patients suffering from Kaposi's sarcoma (KS) and KSHV-related lymphoproliferative diseases (Vaccine, 25:8102-9). Anti-KCP antibodies were more prevalent in individuals suffering from KSHV-related lymphomas than KS and also in those with high titer of antibodies against lytic KSHV antigens. Herein we analyze anti-KCP antibodies in 175 individuals originating from three different groups from northern Sweden or Italy, which included patients suffering from classical or HIV-associated KS, Multicentric Castleman's Disease, KSHV-associated solid lymphoma, pleural effusion lymphoma and healthy individuals with detectable KSHV immune response. Our current study confirmed previous observations concerning antibody prevalence but we also analyzed correlations between anti-KCP antibodies and classical KS evolution, clinical stage and viral load in body fluids. Furthermore, we show that patient's anti-KCP antibodies are able to decrease the ability of KCP to inhibit complement. This fact combined with results of statistical analysis suggests that KCP inactivation by specific antibodies may influence progression of classical KS.}},
author = {{Okroj, Marcin and Tedeschi, Rosamaria and Mancuso, Roberta and Brambilla, Lucia and Tourlaki, Athanasia and Dillner, Joakim and Blom, Anna}},
issn = {{1873-2518}},
language = {{eng}},
pages = {{1129--1134}},
publisher = {{Elsevier}},
series = {{Vaccine}},
title = {{Prevalence of antibodies against Kaposi's sarcoma associated herpes virus (KSHV) complement inhibitory protein (KCP) in KSHV-related diseases and their correlation with clinical parameters.}},
url = {{https://lup.lub.lu.se/search/files/1688001/1768870.pdf}},
doi = {{10.1016/j.vaccine.2010.11.070}},
volume = {{29}},
year = {{2011}},
}